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    v1.0.30
    OpenPayerBilling CodesImmune Globulins, Serum or Recombinant ProductsCPT cpt-90284-subcutaneous-immunoglobulin-injection-scig-igsc
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    CPT 90284: Subcutaneous Immunoglobulin (SCIg) Injection

    CPT code 90284 describes subcutaneous immunoglobulin (SCIg or IgSC) injection, an administration of immunoglobulin to provide passive immunity; the service is an injectable immunoglobulin therapy typically performed in an outpatient clinic or home health setting as a subcutaneous infusion or injection procedure for patients requiring replacement or immune-modulating therapy.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient for 90284 is an adult or pediatric patient with primary or secondary humoral immunodeficiency (for example, common variable immunodeficiency or hypogammaglobulinemia) who receives subcutaneous immunoglobulin (SCIg/IgSC) for passive immunity. The clinical workflow begins with diagnosis and determination of immunoglobulin replacement as medically necessary. The patient is evaluated in an outpatient infusion clinic, allergy/immunology office, or home health setting. Prior to initiation, baseline laboratories (CBC, IgG level, renal function) are obtained and a weight-based dose plan is calculated. For clinic-administered 90284, nursing staff prepare the prescribed SCIg product, select subcutaneous sites, and perform aseptic technique. The patient is observed for local site reactions and systemic adverse events for a brief period after injection. Education is provided on self-administration technique and potential adverse reactions when transitioning to home therapy. Documentation includes indication, lot number, dose, administration route (subcutaneous), injection sites, patient tolerance, and any immediate adverse events.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96372Therapeutic, prophylactic, or diagnostic injection (subcutaneous or intramuscular)Used for administration of subcutaneous medications; sometimes billed when supporting injections or concomitant subcutaneous treatments are given.
    96401Chemotherapy administration, subcutaneous or intramuscular; non-hormonal anti-neoplasticOccasionally referenced for administration technique documentation; not typical for immunoglobulin but similar route-based administration code.
    P9041Immune globulin, subcutaneous, 1 g (often used for billing by HCPCS)Commonly used alongside or instead of 90284 in certain billing systems to report the product quantity (HCPCS codes vary by payer).
    99070Supplies and materials provided by the physician over and above those usually included with the serviceUsed to report ancillary supplies (e.g., infusion pump pads, subcutaneous tubing) when payor allows.
    99000Handling and/or conveyance of specimen for transfer from the office to a laboratoryNot typically used for 90284 but may appear if labs are shipped in the same encounter.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    363L00000X
    208000000X
    207Q00000X
    174400000X
    174M00000X
    261QR0400X
    213ES0000X
    3416L0300X

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-90281-IMMUNOGLOBULIN-THERAPY-INFUSION

    CPT 90281: Immunoglobulin for Passive Immunity

    CPT-90283-IMMUNOGLOBULIN-PASSIVE-IMMUNITY

    CPT 90283: Immunoglobulin for Passive Immunity

    CPT-90287-BOTULISM-ANTITOXIN-EQUINE-GLOBULIN

    CPT 90287: Botulism Antitoxin (Equine Globulin)

    CPT-90288-BOTULISM-IMMUNE-GLOBULIN-INTRAVENOUS

    CPT 90288: Botulism Immune Globulin Intravenous Administration

    CPT-90291-CMV-IMMUNE-GLOBULIN-INTRAVENOUS-INFUSION

    CPT 90291: Cytomegalovirus Immune Globulin (CMV–IgIV) Administration

    CPT-90296-DIPHTHERIA-ANTITOXIN-EQUINE

    CPT 90296: Diphtheria Antitoxin (Equine) Administration

    CPT-90371-HEPATITIS-B-IMMUNOGLOBULIN-HBIG

    CPT 90371: Hepatitis B Immunoglobulin (HBIg) Injection

    CPT-90375-RABIES-IMMUNOGLOBULIN-PASSIVE-IMMUNITY

    CPT 90375: Human Rabies Immunoglobulin for Passive Immunity

    CPT-90376-RABIES-IMMUNOGLOBULIN-HUMAN-POST-EXPOSURE-PROPHYLAXIS

    CPT 90376: Human Rabies Immunoglobulin for Passive Immunity

    CPT-90377-RABIES-IMMUNOGLOBULIN-HUMAN-HIGH-TITER

    CPT 90377: Human Rabies Immunoglobulin for Passive Immunity

    Showing 1–10 of 21

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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