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    v1.0.30
    OpenPayerBilling CodesImmune Globulins, Serum or Recombinant ProductsCPT cpt-90287-botulism-antitoxin-equine-globulin
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    CPT 90287: Botulism Antitoxin (Equine Globulin)

    CPT code 90287 describes administration of Botulism Antitoxin, a refined and concentrated liquid preparation of horse-derived (equine) globulins modified by enzymatic digestion, used to neutralize botulinum toxin; the service is an antitoxin biologic therapy typically administered as an injectable/infusion in acute care settings such as hospital inpatient, emergency department, or other acute care facilities.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A typical scenario involves an emergency department or inpatient adult patient presenting with suspected botulism — progressive, symmetric cranial nerve palsies (diplopia, dysarthria, dysphagia), descending flaccid paralysis, and/or respiratory compromise after foodborne exposure, wound contamination, or injection drug use. After clinical suspicion is established by the emergency physician, neurologist, or infectious disease specialist, public health authorities and the treating team coordinate rapid procurement and administration of botulism antitoxin to neutralize circulating neurotoxin.

    The clinical workflow commonly includes: initial triage and airway assessment; neurologic examination documenting cranial nerve and motor deficits; supportive measures (airway protection, mechanical ventilation if needed); notification of local or state public health for antitoxin release; informed consent discussion with the patient or surrogate; intravenous administration of the antitoxin in a monitored setting (ED, ICU, or inpatient ward) with readiness to manage hypersensitivity reactions; post-administration monitoring for allergic/anaphylactic events and ongoing supportive care including respiratory and nutritional management. Documentation should include time of symptom onset, neurologic findings, indication for antitoxin, lot number and dose of 90287 administered, consent, and any adverse reactions.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36415Collection of venous blood by venipunctureOften performed prior to 90287 to obtain baseline labs (CBC, CMP, blood gases) and confirm supportive care needs.
    93010Electrocardiogram interpretation and report onlyMay be performed to monitor cardiac conduction changes in patients with autonomic involvement.
    94640Pressurized or non-pressurized inhalation treatment for acute airway obstructionUsed for respiratory symptomatic management; may be part of supportive care but not a substitute for antitoxin.
    31500Intubation, endotracheal, emergency procedurePerformed if respiratory failure occurs before or after antitoxin administration; part of airway management in the same clinical episode.
    99223Initial hospital care, typically 70 minutes or moreRepresents initial critical inpatient evaluation and management for severely affected patients receiving 90287 during admission.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    24Modifier 24 denotes an unrelated evaluation and management (E/M) service performed by the same physician or qualified healthcare professional during a postoperative global period. Per CPT guidance,…- Use modifier 24 when you report an evaluation and management (E/M) service performed by the same physician or same-specialty group during a procedure’s postoperative global period that is unrelated…
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RG0100X
    2080P0207X
    207L00000X
    207LP2900X
    363LP0222X
    261QM0855X
    246Q00000X
    111N00000X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    A05.1Botulism food poisoning
    A48.1Legionnaires' disease
    A48.3Toxic shock syndrome
    A48.4Brazilian purpuric fever
    A49.9Bacterial infection, unspecified
    A83.9Mosquito-borne viral encephalitis, unspecified
    A90Dengue fever [classical dengue]
    B83.9Helminthiasis, unspecified
    E86.0Dehydration
    E86.1Hypovolemia

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-90281-IMMUNOGLOBULIN-THERAPY-INFUSION

    CPT 90281: Immunoglobulin for Passive Immunity

    CPT-90283-IMMUNOGLOBULIN-PASSIVE-IMMUNITY

    CPT 90283: Immunoglobulin for Passive Immunity

    CPT-90284-SUBCUTANEOUS-IMMUNOGLOBULIN-INJECTION-SCIG-IGSC

    CPT 90284: Subcutaneous Immunoglobulin (SCIg) Injection

    CPT-90288-BOTULISM-IMMUNE-GLOBULIN-INTRAVENOUS

    CPT 90288: Botulism Immune Globulin Intravenous Administration

    CPT-90291-CMV-IMMUNE-GLOBULIN-INTRAVENOUS-INFUSION

    CPT 90291: Cytomegalovirus Immune Globulin (CMV–IgIV) Administration

    CPT-90296-DIPHTHERIA-ANTITOXIN-EQUINE

    CPT 90296: Diphtheria Antitoxin (Equine) Administration

    CPT-90371-HEPATITIS-B-IMMUNOGLOBULIN-HBIG

    CPT 90371: Hepatitis B Immunoglobulin (HBIg) Injection

    CPT-90375-RABIES-IMMUNOGLOBULIN-PASSIVE-IMMUNITY

    CPT 90375: Human Rabies Immunoglobulin for Passive Immunity

    CPT-90376-RABIES-IMMUNOGLOBULIN-HUMAN-POST-EXPOSURE-PROPHYLAXIS

    CPT 90376: Human Rabies Immunoglobulin for Passive Immunity

    CPT-90377-RABIES-IMMUNOGLOBULIN-HUMAN-HIGH-TITER

    CPT 90377: Human Rabies Immunoglobulin for Passive Immunity

    Showing 1–10 of 21

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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