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    v1.0.30
    OpenPayerBilling CodesImmune Globulins, Serum or Recombinant ProductsCPT cpt-90371-hepatitis-b-immunoglobulin-hbig
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    CPT 90371: Hepatitis B Immunoglobulin (HBIg) Injection

    CPT code 90371 describes hepatitis B immunoglobulin (HBIg), a pooled human plasma–derived immunoglobulin product providing passive immunity against hepatitis B; the service is administration of HBIg typically as an injectable immunoglobulin therapy given in outpatient clinics, emergency departments, or inpatient settings for post‑exposure prophylaxis or protection in high‑risk exposures.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A 34-year-old patient with recent occupational exposure to a known HBsAg-positive source presents to the outpatient occupational health clinic within 14 days of a needlestick injury. The clinician documents the exposure, reviews the patients vaccination history, and orders hepatitis B surface antibody testing. Because the patient is not immune and needs immediate passive protection, hepatitis B immune globulin (HBIg) is administered intramuscularly during the visit. The visit includes pre-administration counseling, informed consent, verification of lot and expiration of 90371 product, administration by a registered nurse, observation for 15–30 minutes for adverse reaction, and documentation of the dose, route, site, lot number, and patient response in the medical record.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularUsed for administration of injections in outpatient settings; sometimes reported when facility or payer prefers injection administration code instead of specific biologic code.
    90460Immunization administration through 18 years of age via any route of administration; first or only component of each vaccine or toxoid administeredNot directly applicable for adult HBIg but related to immunization administration reporting workflows.
    90471Immunization administration (includes percutaneous, intradermal, subcutaneous, or intramuscular) single or initial vaccine/toxoidUsed to report the administration service when payers require separate administration code alongside the biologic.
    86621Hepatitis B surface antibody (anti-HBs)Laboratory test commonly ordered before or after HBIg to assess immunity or response.
    80081Hepatic function panelOften ordered to evaluate baseline liver status in cases of hepatitis exposure.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    208000000X
    3336C0003X
    363L00000X
    164W00000X
    156F00000X
    3416L0300X
    103TF0200X

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-90281-IMMUNOGLOBULIN-THERAPY-INFUSION

    CPT 90281: Immunoglobulin for Passive Immunity

    CPT-90283-IMMUNOGLOBULIN-PASSIVE-IMMUNITY

    CPT 90283: Immunoglobulin for Passive Immunity

    CPT-90284-SUBCUTANEOUS-IMMUNOGLOBULIN-INJECTION-SCIG-IGSC

    CPT 90284: Subcutaneous Immunoglobulin (SCIg) Injection

    CPT-90287-BOTULISM-ANTITOXIN-EQUINE-GLOBULIN

    CPT 90287: Botulism Antitoxin (Equine Globulin)

    CPT-90288-BOTULISM-IMMUNE-GLOBULIN-INTRAVENOUS

    CPT 90288: Botulism Immune Globulin Intravenous Administration

    CPT-90291-CMV-IMMUNE-GLOBULIN-INTRAVENOUS-INFUSION

    CPT 90291: Cytomegalovirus Immune Globulin (CMV–IgIV) Administration

    CPT-90296-DIPHTHERIA-ANTITOXIN-EQUINE

    CPT 90296: Diphtheria Antitoxin (Equine) Administration

    CPT-90375-RABIES-IMMUNOGLOBULIN-PASSIVE-IMMUNITY

    CPT 90375: Human Rabies Immunoglobulin for Passive Immunity

    CPT-90376-RABIES-IMMUNOGLOBULIN-HUMAN-POST-EXPOSURE-PROPHYLAXIS

    CPT 90376: Human Rabies Immunoglobulin for Passive Immunity

    CPT-90377-RABIES-IMMUNOGLOBULIN-HUMAN-HIGH-TITER

    CPT 90377: Human Rabies Immunoglobulin for Passive Immunity

    Showing 1–10 of 21

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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