CPT 90375 Rabies Immunoglobulin Reimbursement | OpenPayer

Summary & Overview

CPT 90375: Rabies Immunoglobulin for Post-Exposure Passive Immunity

CPT code 90375 identifies rabies immunoglobulin (RIg), a human plasma–derived gamma globulin preparation with high titers of rabies antibodies used for passive immunization after category III rabies exposures. Nationally, RIg is a critical component of rabies post-exposure prophylaxis because it provides immediate neutralizing antibodies until active immunity from rabies vaccination develops. Access to and coverage of RIg affect emergency care pathways and public health responses to potential rabies exposures.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context for 90375, typical sites of service, and payer coverage considerations. The publication outlines benchmarking metrics relevant to utilization and reimbursement, highlights policy updates that influence coverage and coding practice, and summarizes clinical implications for delivering timely post-exposure prophylaxis. Where input data are incomplete, the report notes that specific details are not available in the input and focuses on nationally relevant guidance and interpretation rather than jurisdictional specifics.

AetnaBlue Cross Blue ShieldCigna HealthUnitedHealthcareMedicare90375CPTrabies immunoglobulinpost-exposure prophylaxishuman immunoglobulininfectious diseaseemergency careinfusion therapy

Billing Code Overview

CPT code 90375 describes rabies immunoglobulin (RIg) derived from pooled human plasma with high-titer antibodies to rabies virus. This biologic provides passive immunity and is used for prevention or treatment of category III rabies exposures, supplying immediate antibodies to neutralize virus at the exposure site.

Service type: Administration of a human-derived immunoglobulin product for post-exposure prophylaxis
Typical site of service: Emergency department, inpatient facility, urgent care center, or outpatient infusion clinic where rabies post-exposure treatment is provided

Data not available in the input.

Clinical & Coding Specifications

Clinical Context

A 32-year-old unvaccinated adult presents to the emergency department after a category III exposure: a deep transdermal bite to the forearm by a stray dog while traveling in a rabies-endemic area. Wounds are irrigated and cleansed; tetanus status is verified. Because the patient has not previously received rabies vaccine, passive immunization with human rabies immune globulin is indicated and administered as a single infiltrative dose around the wound and any residual volume given intramuscularly. The typical clinical workflow includes wound care, risk assessment for rabies exposure, informed consent, calculation of the immune globulin dose based on body weight, local infiltration of as much as anatomically feasible into and around the wound, and documentation of lot number, dose, route, site, time, and supervising clinician.

Typical site of service is an emergency department, urgent care clinic, or hospital outpatient infusion/ procedural area. The procedure is performed by emergency medicine physicians, infectious disease specialists, or other credentialed clinicians (physicians, physician assistants, or nurse practitioners) trained to administer immunoglobulin and manage post-exposure prophylaxis.

Coding Specifications

Modifier	Description	When to Use
`25`	Significant, separately identifiable evaluation and management service by the same physician on the same day of the procedure	Use when an E/M visit is performed and documented separately from the immunoglobulin administration (e.g., history, exam, decision-making for PEP).

CPT 90378: Respiratory Syncytial Virus Immune Globulin, Intramuscular

CPT-90371-HEPATITIS-B-IMMUNOGLOBULIN-HBIG

CPT 90371: Hepatitis B Immunoglobulin (HBIg)

CPT-90385-RHOD-IMMUNOGLOBULIN-PREVENT-RHESUS-DISEASE

CPT 90385: Rho(D) Immunoglobulin to Prevent Hemolytic Disease of the Newborn

CPT-90284-SUBCUTANEOUS-IMMUNOGLOBULIN-INJECTION-SCIG-IGSC

CPT 90284: Subcutaneous Immunoglobulin Injection (SCIg/IgSC)

CPT-90389-TETANUS-IMMUNOGLOBULIN-PASSIVE-IMMUNIZATION

CPT 90389: Tetanus Immunoglobulin for Passive Immunization

CPT-90377-RABIES-IMMUNOGLOBULIN-HUMAN-HIGH-TITER

CPT 90377: Human Rabies Immunoglobulin, High-Titer

CPT-90291-CMV-IMMUNE-GLOBULIN-INTRAVENOUS-INFUSION

CPT 90291: Cytomegalovirus Immune Globulin (CMV–IgIV) Infusion

CPT-90396-VARICELLA-ZOSTER-IMMUNE-GLOBULIN-IMMUNOPROPHYLAXIS

CPT 90396: Intramuscular Varicella–Zoster Immune Globulin Supply

CPT-90381-RSV-MONOCLONAL-ANTIBODY-IMMUNIZATION-1ML

CPT 90381: RSV Monoclonal Antibody Intramuscular Immunization, 1 mL

CPT-90287-BOTULISM-ANTITOXIN-EQUINE-GLOBULIN

CPT 90287: Botulism Antitoxin, Equine-Derived Globulin

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Taxonomy Code	Specialty	Notes
`207P00000X`	Emergency Medicine Physician	Common clinician administering rabies immune globulin in ED settings.
`208000000X`	Family Medicine Physician	May provide wound care and administer PEP in urgent care or clinic settings.
`208D00000X`	Infectious Disease Specialist	Consulted for complex exposures, immunocompromised patients, or vaccine scheduling.
`363LF0000X`	Registered Nurse	Often performs preparation and administration under protocol.
`363LA2200X`	Physician Assistant	Frequently assists with wound infiltration and administration under supervising physician.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`A82.9`	Rabies, unspecified	Direct diagnosis indicating rabies exposure or infection risk prompting passive immunization.
`Z20.822`	Contact with and (suspected) exposure to rabies	Indicates documented exposure to rabies virus; supports need for rabies PEP including immunoglobulin.
`S01.812A`	Puncture wound with foreign body of right forearm, initial encounter	Example wound code for a bite injury that may require local infiltration with rabies immunoglobulin.
`S61.219A`	Unspecified open wound, left wrist, initial encounter	Representative code for open wounds from animal bites requiring local treatment and RIG.
`Z23`	Encounter for immunization	Used to document administration of biologic prophylaxis as part of preventive care workflow.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance)	Used for intramuscular administration of immunoglobulin when billed separately from the drug code; documents injection administration service.
`96365`	Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour	Used if immunoglobulin is delivered via IV infusion rather than local wound infiltration or IM.
`90471`	Immunization administration (single) by intramuscular, intradermal or subcutaneous injection	Alternative administration code for vaccine/biologic injections when applicable documentation supports use.
`99070`	Supplies and materials (e.g., drugs, sutures) provided by the physician over and above those usually included with the office visit	Used for additional non-billable supplies related to wound care or administration not included elsewhere.
`96360`	Intravenous infusion, hydration; initial, 31 minutes to 1 hour	May be reported when concurrent IV fluids are administered during the immunoglobulin infusion.

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