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    OpenPayerBilling CodesImmune Globulins, Serum or Recombinant ProductsCPT cpt-90291-cmv-immune-globulin-intravenous-infusion
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    CPT 90291: Cytomegalovirus Immune Globulin (CMV–IgIV) Administration

    CPT code 90291 describes administration of Cytomegalovirus immune globulin (CMV–IgIV), a pooled human immunoglobulin preparation used to provide passive immunity against cytomegalovirus; the service is an intravenous immunoglobulin product administration for infectious disease prophylaxis and is typically delivered in an outpatient infusion center or hospital infusion department. Immunoglobulin therapy provides passive immunity by supplying antibodies, and CMV–IgIV specifically targets prevention of cytomegalovirus infection in high-risk patients. Service type: intravenous immune globulin product administration. Typical site of service: outpatient infusion center or hospital-based infusion unit.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a solid-organ transplant recipient (for example, lung or liver transplant) who receives intravenous Cytomegalovirus immune globulin (CMV–IgIV) as part of prophylaxis or early treatment to prevent or mitigate cytomegalovirus infection. The clinical workflow begins with identification of CMV serostatus (donor and recipient), assessment of risk (D+/R- highest risk), and an order for passive immunoprophylaxis when indicated. The patient usually presents to an outpatient infusion center, hospital outpatient department, or inpatient ward. Prior to infusion, nursing documents informed consent, verifies identity and allergies, and checks baseline vital signs and intravenous access. Pharmacy compounds or dispenses the pooled immunoglobulin product per manufacturer instructions; the product is labeled and may require the JW modifier if discarded partial doses are billed. During infusion, nursing monitors for infusion reactions and documents administration time, lot number, and volume infused. Post-infusion, vital signs and adverse event monitoring continue; documentation includes clinical indication, dose, route, lot numbers, and any infusion-related events. Billing is submitted for the administered immune globulin using 90291 with appropriate modifiers as indicated by payor rules and clinical circumstances.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36415Collection of venous blood by venipunctureCommonly performed before 90291 for baseline labs (CMV serology, CBC, chemistries) to guide therapy.
    96365Intravenous infusion, initial, up to 1 hourUsed when an IV infusion service is billed for administration of biologic products; may be billed alongside or in coordination with 90291 per payor rules.
    90282Hepatitis B immune globulin administrationRepresents other immune globulin product codes; listed as a related biologic administration code for cross-reference in billing workflows.
    99070Supplies and materials (non-covered)Used to bill ancillary supplies used during infusion (IV tubing, flushes) when payor allows.
    36416Collection of capillary blood specimenMay be used for point-of-care testing associated with the infusion encounter.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208100000X
    207L00000X
    163W00000X
    251S00000X
    2471N0900X
    2088P0231X
    207YP0228X
    2471C1106X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    B00.9Herpesviral infection, unspecified
    B19.20Unspecified viral hepatitis C without hepatic coma
    B20Human immunodeficiency virus [HIV] disease
    B25.0Cytomegaloviral pneumonitis
    B25.1Cytomegaloviral hepatitis
    B25.9Cytomegaloviral disease, unspecified
    D47.Z2Castleman disease
    D61.9Aplastic anemia, unspecified
    D70.9Neutropenia, unspecified

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-90281-IMMUNOGLOBULIN-THERAPY-INFUSION

    CPT 90281: Immunoglobulin for Passive Immunity

    CPT-90283-IMMUNOGLOBULIN-PASSIVE-IMMUNITY

    CPT 90283: Immunoglobulin for Passive Immunity

    CPT-90284-SUBCUTANEOUS-IMMUNOGLOBULIN-INJECTION-SCIG-IGSC

    CPT 90284: Subcutaneous Immunoglobulin (SCIg) Injection

    CPT-90287-BOTULISM-ANTITOXIN-EQUINE-GLOBULIN

    CPT 90287: Botulism Antitoxin (Equine Globulin)

    CPT-90288-BOTULISM-IMMUNE-GLOBULIN-INTRAVENOUS

    CPT 90288: Botulism Immune Globulin Intravenous Administration

    CPT-90296-DIPHTHERIA-ANTITOXIN-EQUINE

    CPT 90296: Diphtheria Antitoxin (Equine) Administration

    CPT-90371-HEPATITIS-B-IMMUNOGLOBULIN-HBIG

    CPT 90371: Hepatitis B Immunoglobulin (HBIg) Injection

    CPT-90375-RABIES-IMMUNOGLOBULIN-PASSIVE-IMMUNITY

    CPT 90375: Human Rabies Immunoglobulin for Passive Immunity

    CPT-90376-RABIES-IMMUNOGLOBULIN-HUMAN-POST-EXPOSURE-PROPHYLAXIS

    CPT 90376: Human Rabies Immunoglobulin for Passive Immunity

    CPT-90377-RABIES-IMMUNOGLOBULIN-HUMAN-HIGH-TITER

    CPT 90377: Human Rabies Immunoglobulin for Passive Immunity

    Showing 1–10 of 21

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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