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    v1.0.30
    OpenPayerBilling CodesImmune Globulins, Serum or Recombinant ProductsCPT cpt-90376-rabies-immunoglobulin-human-post-exposure-prophylaxis
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    CPT 90376: Human Rabies Immunoglobulin for Passive Immunity

    CPT code 90376 describes human rabies immunoglobulin (RIg) derived from pooled human plasma with high rabies antibody titer used to provide passive immunity for prevention or treatment of category III rabies exposures; service type: administration of immunoglobulin for post‑exposure prophylaxis or treatment; typical site of service: outpatient clinic, emergency department, or inpatient hospital setting where biologicals are administered.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a previously unvaccinated adult or child presenting after a high‑risk animal bite or other exposure consistent with category III rabies exposure (transdermal bite, contamination of mucous membrane with saliva, or multiple severe bites). The patient arrives to the emergency department or urgent care clinic; triage documents the exposure mechanism, wound severity, and timing. The clinician assesses tetanus status, performs wound cleansing and closure as indicated, and determines rabies post‑exposure prophylaxis is required. Rabies immunoglobulin (90376) is calculated by weight (human rabies immunoglobulin), infiltrated around wounds when feasible, with any remaining volume administered intramuscularly at a distant site, and given once at initiation of post‑exposure prophylaxis together with rabies vaccine series. Typical sites of service are hospital emergency departments, urgent care centers, outpatient clinics with immunization capability, and public health clinics. The clinical workflow includes patient assessment, informed consent, weight‑based dose calculation, wound infiltration technique, documentation of lot and expiration numbers, observation for immediate adverse reaction, and scheduling of vaccine doses for completion of prophylaxis.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    A9270Non‑covered item or service (used for reporting certain immunoglobulin products)Often used by payors for reporting or tracking of rabies immunoglobulin products when specific HCPCS is required; administrative relation to drug billing (note: A9270 is a HCPCS miscellaneous code)
    90471Immunization administration (single) by intramuscular injectionUsed when rabies immunoglobulin or vaccine is administered intramuscularly and separate administration code is reportable
    90472Immunization administration (each additional)Used for additional vaccines administered during the same encounter (for vaccine series or multiple injections)
    90460Immunization administration through 18 years of age; with counseling by physician or other qualified health care professionalWhen counseling accompanies vaccine/immunoglobulin administration for pediatric patients
    11042Debridement, subcutaneous tissue (simple)May be performed prior to local infiltration if wound requires debridement in the ED or OR setting
    99283Emergency department visit, moderate complexityTypical E/M code billed for ED encounters where rabies immunoglobulin is administered; relates to initial clinical evaluation and management

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208D00000X
    363LF0000X
    207P00000X
    207L00000X
    207RC0001X
    2084P0804X
    261QA1903X
    1710I1003X

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-90281-IMMUNOGLOBULIN-THERAPY-INFUSION

    CPT 90281: Immunoglobulin for Passive Immunity

    CPT-90283-IMMUNOGLOBULIN-PASSIVE-IMMUNITY

    CPT 90283: Immunoglobulin for Passive Immunity

    CPT-90284-SUBCUTANEOUS-IMMUNOGLOBULIN-INJECTION-SCIG-IGSC

    CPT 90284: Subcutaneous Immunoglobulin (SCIg) Injection

    CPT-90287-BOTULISM-ANTITOXIN-EQUINE-GLOBULIN

    CPT 90287: Botulism Antitoxin (Equine Globulin)

    CPT-90288-BOTULISM-IMMUNE-GLOBULIN-INTRAVENOUS

    CPT 90288: Botulism Immune Globulin Intravenous Administration

    CPT-90291-CMV-IMMUNE-GLOBULIN-INTRAVENOUS-INFUSION

    CPT 90291: Cytomegalovirus Immune Globulin (CMV–IgIV) Administration

    CPT-90296-DIPHTHERIA-ANTITOXIN-EQUINE

    CPT 90296: Diphtheria Antitoxin (Equine) Administration

    CPT-90371-HEPATITIS-B-IMMUNOGLOBULIN-HBIG

    CPT 90371: Hepatitis B Immunoglobulin (HBIg) Injection

    CPT-90375-RABIES-IMMUNOGLOBULIN-PASSIVE-IMMUNITY

    CPT 90375: Human Rabies Immunoglobulin for Passive Immunity

    CPT-90377-RABIES-IMMUNOGLOBULIN-HUMAN-HIGH-TITER

    CPT 90377: Human Rabies Immunoglobulin for Passive Immunity

    Showing 1–10 of 21

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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