CPT code 86280 describes a laboratory immunoassay using the hemagglutination inhibition (HAI) method to detect antibodies to a specific antigen in a patient’s blood sample. This assay is important for diagnosing and monitoring immune responses in infectious diseases and vaccine evaluation. Nationally, accurate coding for specialized serologic tests like HAI matters for clinical interpretation, laboratory workflow, and payer coverage decisions.

Key payers covered include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find an overview of the clinical purpose of the HAI immunoassay, typical sites of service, common billing modifiers associated with laboratory services, and which payers commonly cover similar serologic testing. The publication provides benchmarks on reimbursement patterns, coding guidance context, and policy updates relevant to lab reimbursement and claims processing.

This summary equips laboratory managers, billing professionals, and policy analysts with the clinical context and payer landscape for CPT code 86280, clarifying where the test is performed and why precise coding and documentation matter for claim adjudication and public health reporting.