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    v1.0.30
    OpenPayerBilling CodesQualitative or Semiquantitative ImmunoassaysCPT cpt-86021-leukocyte-antibody-identification-lab-technical
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    CPT 86021: Leukocyte Antibody Identification Laboratory Test

    CPT code 86021 describes a laboratory technical procedure in which a lab analyst performs testing to detect the presence of and identify leukocyte antibodies; this service is a specialty immunohematology lab test typically performed in a clinical laboratory or hospital laboratory setting as a technical component of antibody identification and compatibility testing.

    For related coverage guidance, see recent payer policy updates: Allergy Testing, Including Selected Blood, Serum and Cellular Testing and Toxicity Testing Corporate Medical Policy, Allergy Testing and Injections, Allergy Testing.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 32-year-old pregnant woman presents for routine prenatal blood testing following a prior pregnancy complicated by hemolytic disease of the newborn. Her prenatal laboratory panel flags a positive antibody screen. A blood specimen is sent to the hospital transfusion medicine laboratory where a medical laboratory scientist performs specialized serologic testing to detect and identify leukocyte (white blood cell) antibodies that may affect transfusion compatibility or cause alloimmune fetal/neonatal complications. The lab workflow includes receipt and accessioning of the specimen, verification of patient identifiers and clinical history, performance of antibody detection/enzyme-linked or flow-based assays, interpretation by a qualified technologist, and reporting of results into the electronic medical record for the ordering clinician and transfusion service.

    Typical site of service is an accredited hospital clinical laboratory or independent reference immunohematology/transfusion medicine laboratory. The service type is a technical laboratory procedure performed by trained laboratory personnel to analyze for the presence of and identify leukocyte antibodies; results inform transfusion decisions, organ transplant compatibility assessment, and management of alloimmune conditions in pregnancy.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    86038Antibody identification; serum, each panelPerformed when an antibody screen is positive to identify specific red cell or leukocyte antibodies; often follows initial antibody detection.
    86850Crossmatch, serologicPerformed to assess compatibility between donor and recipient blood when leukocyte or other antibodies are present; may follow identification testing.
    86830Blood typing; ABOBasic transfusion testing that is part of the overall immunohematology workflow alongside leukocyte antibody identification.
    86900Compatibility test; antilymphocyte/antigranulocyte crossmatchRelevant when specialized compatibility testing involving leukocyte-directed antibodies is required for transplant or transfusion.
    86148Antibody screen, platelet or granulocytePlatelet or granulocyte antibody testing is complementary when leukocyte antibodies affecting transfusion products are suspected.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207K00000X
    207L00000X
    207P00000X
    3336C0003X
    2865X1600X
    2083P0500X
    103TF0000X
    261QR1100X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    D56.0Alpha thalassemia
    D56.1Beta thalassemia
    D58.9Hereditary hemolytic anemia, unspecified
    D61.9Aplastic anemia, unspecified
    D63.0Anemia in neoplastic disease
    D66Hereditary factor VIII deficiency
    D67Hereditary factor IX deficiency
    D69.9Hemorrhagic condition, unspecified
    I50.9Heart failure, unspecified
    I85.01Esophageal varices with bleeding

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Allergy/Clinical Immunology1 / 3

    10 rows

    PolicyPayerEffective Date
    Allergy Testing, Including Selected Blood, Serum and Cellular Testing and Toxicity Testing Corporate Medical Policybcbsvermont2026-11-01
    Allergy Testing and InjectionsUnitedHealthcare2026-10-01
    Allergy TestingProvidence Health Plan2026-10-01
    Diagnosis of Idiopathic Environmental IntoleranceOscar Health2026-10-01
    Allergen Testingblue cross blue shield - louisiana2026-09-15
    Allergen TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Hereditary Angioedema - EkterlyCigna2026-08-15
    Omalizumab products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab Products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab ProductsPremera Bluecross2026-08-01

    Related Codes

    86803-QUALITATIVE-OR-SEMIQUANTITATIVE-IMMUNOASSAYS-HEPATITIS-C

    CPT 86803: Hepatitis C Antibody Immunoassay in Serum

    CPT-86000-FEBRILE-AGGLUTININS-SEROLOGIC-TEST

    CPT 86000: Febrile Agglutinins (Serologic Agglutination) Test

    CPT-86001-ALLERGEN-SPECIFIC-IGG-LABORATORY-TEST

    CPT 86001: Allergen-Specific IgG Assay, Technical Component

    CPT-86003-ALLERGEN-SPECIFIC-IGE-ASSAY-TECHNICAL

    CPT 86003: Allergen‑Specific IgE Assay Using Crude Allergen Extract

    CPT-86005-MULTI-ALLERGEN-IGE-SCREENING-QUALITATIVE

    CPT 86005: Multi-Allergen Allergen-Specific IgE Screening

    CPT-86008-ALLERGEN-COMPONENT-SPECIFIC-IGE-ASSAY

    CPT 86008: Allergen Component–Specific IgE Assay

    CPT-86015-ANTI-ACTIN-SMOOTH-MUSCLE-ANTIBODY-ASMA

    CPT 86015: Actin (Smooth Muscle) Antibody (ASMA) Immunoassay

    CPT-86022-PLATELET-ANTIBODY-IDENTIFICATION-TECHNICAL-TEST

    CPT 86022: Platelet Antibody Detection and Identification

    CPT-86023-PLATELET-ASSOCIATED-IMMUNOGLOBULIN-DETECTION

    CPT 86023: Platelet-Associated Immunoglobulin Assay

    CPT-86036-ANTINEUTROPHIL-CYTOPLASMIC-ANTIBODY-ANALYIS

    CPT 86036: Antineutrophil Cytoplasmic Antibody (ANCA) Immunoassay

    Showing 1–10 of 199

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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