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    v1.0.30
    OpenPayerBilling CodesQualitative or Semiquantitative ImmunoassaysCPT cpt-86023-platelet-associated-immunoglobulin-detection
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    CPT 86023: Platelet-Associated Immunoglobulin Assay

    CPT code 86023 describes a laboratory technical assay performed by a lab analyst to detect and identify platelet-associated immunoglobulins in patient blood, a specialized serologic test used in diagnosing immune-mediated platelet disorders; service type: clinical laboratory test (immunohematology/serology); typical site of service: clinical laboratory or hospital laboratory.

    For related coverage guidance, see recent payer policy updates: Allergy Testing, Including Selected Blood, Serum and Cellular Testing and Toxicity Testing Corporate Medical Policy, Allergy Testing and Injections, Allergy Testing.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 48-year-old patient presents to the hematology clinic with unexplained thrombocytopenia and mucocutaneous bleeding. The clinician orders laboratory evaluation to determine whether platelet-associated immunoglobulins are present to support a diagnosis of immune thrombocytopenic purpura (ITP) or other immune-mediated platelet destruction. A phlebotomy draw is performed in the outpatient lab; the specimen is labeled and transported to the hospital clinical immunology laboratory. The lab analyst performs 86023, a technical assay that detects and identifies platelet-associated immunoglobulins. Results are reported to the ordering hematologist, who integrates these findings with CBC, peripheral smear, and clinical history to confirm immune-mediated platelet loss or to pursue alternate etiologies such as drug-induced thrombocytopenia or post-transfusion purpura. Typical site of service is an outpatient clinical laboratory or hospital clinical laboratory within an ambulatory or inpatient setting. The service type is a clinical laboratory diagnostic immunology test performed by a certified medical technologist or lab analyst.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    85025Complete blood count (CBC) with automated differentialInitial screening test to document thrombocytopenia and guide need for platelet antibody testing.
    85027Automated platelet countProvides quantitative platelet count used alongside 86023 to assess severity of thrombocytopenia.
    85300Platelet function studies; platelet aggregation, each procedurePerformed when platelet dysfunction, rather than immune destruction, is suspected following 86023.
    86850Platelet crossmatch for transfusionUsed when immune-mediated platelet destruction is suspected and compatible platelet transfusion is considered.
    86140Antibody detection by solid phase (e.g., ELISA)Alternative or complementary immunoassay methods that may be performed in the same immunology workflow as 86023.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    207K00000X
    207L00000X
    2080P0202X
    246XC2903X
    364SP0200X
    103TW0100X
    156FX1100X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    A91Dengue hemorrhagic fever
    B37.7Candidal sepsis
    B59Pneumocystosis
    D68.4Acquired coagulation factor deficiency
    D68.9Coagulation defect, unspecified
    D69.0Allergic purpura
    D69.1Qualitative platelet defects
    D69.2Other nonthrombocytopenic purpura
    D69.3Immune thrombocytopenic purpura
    D69.59Other secondary thrombocytopenia

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Allergy/Clinical Immunology1 / 3

    10 rows

    PolicyPayerEffective Date
    Allergy Testing, Including Selected Blood, Serum and Cellular Testing and Toxicity Testing Corporate Medical Policybcbsvermont2026-11-01
    Allergy Testing and InjectionsUnitedHealthcare2026-10-01
    Allergy TestingProvidence Health Plan2026-10-01
    Diagnosis of Idiopathic Environmental IntoleranceOscar Health2026-10-01
    Allergen Testingblue cross blue shield - louisiana2026-09-15
    Allergen TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Hereditary Angioedema - EkterlyCigna2026-08-15
    Omalizumab products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab Products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab ProductsPremera Bluecross2026-08-01

    Related Codes

    86803-QUALITATIVE-OR-SEMIQUANTITATIVE-IMMUNOASSAYS-HEPATITIS-C

    CPT 86803: Hepatitis C Antibody Immunoassay in Serum

    CPT-86000-FEBRILE-AGGLUTININS-SEROLOGIC-TEST

    CPT 86000: Febrile Agglutinins (Serologic Agglutination) Test

    CPT-86001-ALLERGEN-SPECIFIC-IGG-LABORATORY-TEST

    CPT 86001: Allergen-Specific IgG Assay, Technical Component

    CPT-86003-ALLERGEN-SPECIFIC-IGE-ASSAY-TECHNICAL

    CPT 86003: Allergen‑Specific IgE Assay Using Crude Allergen Extract

    CPT-86005-MULTI-ALLERGEN-IGE-SCREENING-QUALITATIVE

    CPT 86005: Multi-Allergen Allergen-Specific IgE Screening

    CPT-86008-ALLERGEN-COMPONENT-SPECIFIC-IGE-ASSAY

    CPT 86008: Allergen Component–Specific IgE Assay

    CPT-86015-ANTI-ACTIN-SMOOTH-MUSCLE-ANTIBODY-ASMA

    CPT 86015: Actin (Smooth Muscle) Antibody (ASMA) Immunoassay

    CPT-86021-LEUKOCYTE-ANTIBODY-IDENTIFICATION-LAB-TECHNICAL

    CPT 86021: Leukocyte Antibody Identification Laboratory Test

    CPT-86022-PLATELET-ANTIBODY-IDENTIFICATION-TECHNICAL-TEST

    CPT 86022: Platelet Antibody Detection and Identification

    CPT-86036-ANTINEUTROPHIL-CYTOPLASMIC-ANTIBODY-ANALYIS

    CPT 86036: Antineutrophil Cytoplasmic Antibody (ANCA) Immunoassay

    Showing 1–10 of 199

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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