ICD-10-CM Code For Other Sepsis: Group Overview

The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group A41 includes sepsis due to non-specified or other bacterial pathogens, covering bacteremia-associated systemic infections and sepsis of varying severity. These ICD-10-CM diagnosis codes are used to document episodes of systemic inflammatory response to bacterial infection, capturing disease severity, organ involvement, or clinical complexity relevant to this group. Accurate coding within the ICD-10-CM A41 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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ICD-10-CM A41: Other Sepsis Overview

The ICD-10-CM A41 group captures sepsis due to various bacterial pathogens that are not classified elsewhere, representing systemic inflammatory responses to bacterial infection. These conditions affect multiple organ systems and can rapidly progress to severe sepsis or septic shock. Accurate coding is important for reflecting clinical severity and supporting appropriate reimbursement and resource allocation.

When to Use

Use a code from this group when clinical documentation indicates sepsis attributable to bacterial pathogens not otherwise specified or categorized in other sepsis codes. Select the appropriate code to reflect severity, associated organ dysfunction, and any identified bacterial organism when documented.

ICD-10-CM Codes

15 rows

ICD-10-CM Code	Description
A41.01	Sepsis due to Methicillin susceptible Staphylococcus aureus
A41.02	Sepsis due to Methicillin resistant Staphylococcus aureus
A41.1	Sepsis due to other specified staphylococcus
A41.2	Sepsis due to unspecified staphylococcus
A41.3	Sepsis due to Hemophilus influenzae
A41.4	Sepsis due to anaerobes
A41.50	Gram-negative sepsis, unspecified
A41.51	Sepsis due to Escherichia coli [E. coli]
A41.52	Sepsis due to Pseudomonas
A41.53	Sepsis due to Serratia
A41.54	Sepsis due to Acinetobacter baumannii
A41.59	Other Gram-negative sepsis
A41.81	Sepsis due to Enterococcus
A41.89	Other specified sepsis
A41.9	Sepsis, unspecified organism

DRG Codes

8 rows

DRG Code	Description
791	Prematurity with Major Problems
793	Full Term Neonate with Major Problems
870	Septicemia or Severe Sepsis with MV >96 Hours
871	Septicemia or Severe Sepsis without MV >96 Hours with MCC
872	Septicemia or Severe Sepsis without MV >96 Hours without MCC
974	HIV with Major Related Condition with MCC
975	HIV with Major Related Condition with CC
976	HIV with Major Related Condition without CC/MCC

Typical Clinical Scenarios

An elderly nursing home resident with multiple comorbidities presents to the emergency department with sudden onset fever, hypotension, tachycardia, and altered mental status after a suspected urinary tract infection; blood cultures later grow Escherichia coli and the patient meets systemic inflammatory response criteria with organ dysfunction. A sepsis diagnosis from this group is assigned to capture the acute bloodstream infection and systemic response requiring IV antibiotics and hemodynamic support. Typical codes: A41.51, A41.9
A middle-aged patient hospitalized for severe community-acquired pneumonia develops new-onset respiratory failure and shock despite antibiotic therapy; cultures identify Staphylococcus aureus as the causative organism. Because the patient has a primary bacterial infection with systemic manifestations and organ dysfunction while inpatient, a code from this group is used to document sepsis due to the identified organism and guide severity coding. Typical codes: A41.01, A41.4
A postoperative immunocompromised oncology patient on chemotherapy develops low-grade fever and malaise over several days and is subsequently found to have a gram-negative bacteremia without a specified organism on initial testing; the sepsis diagnosis is recorded as a complicating comorbidity impacting ongoing cancer treatment and hospitalization. A nonspecific sepsis code from this group is assigned when the precise bacterial species is not identified or documented. Typical codes: A41.9, A41.5

Related Codes

A30-LEPROSY-HANSEN-S-DISEASE

ICD-10-CM Code For Leprosy Hansen's Disease: Group Overview

A31-INFECTION-DUE-TO-OTHER-MYCOBACTERIA

ICD-10-CM Code For Infection Due To Other Mycobacteria: Group Overview

A32-LISTERIOSIS

ICD-10-CM Code For Listeriosis: Group Overview

A33-TETANUS-NEONATORUM

ICD-10-CM Code For Tetanus Neonatorum: Group Overview

A34-OBSTETRICAL-TETANUS

ICD-10-CM Code For Obstetrical Tetanus: Group Overview

A35-OTHER-TETANUS

ICD-10-CM Code For Other Tetanus: Group Overview

A36-DIPHTHERIA

ICD-10-CM Code For Diphtheria: Group Overview

A37-WHOOPING-COUGH

ICD-10-CM Code For Whooping Cough: Group Overview

A38-SCARLET-FEVER

ICD-10-CM Code For Scarlet Fever: Group Overview

A39-MENINGOCOCCAL-INFECTION

ICD-10-CM Code For Meningococcal Infection: Group Overview

Showing 1–10 of 16

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-CM Codes

15 rows

ICD-10-CM Code	Description
A41.01	Sepsis due to Methicillin susceptible Staphylococcus aureus
A41.02	Sepsis due to Methicillin resistant Staphylococcus aureus
A41.1	Sepsis due to other specified staphylococcus
A41.2	Sepsis due to unspecified staphylococcus
A41.3	Sepsis due to Hemophilus influenzae
A41.4	Sepsis due to anaerobes
A41.50	Gram-negative sepsis, unspecified
A41.51	Sepsis due to Escherichia coli [E. coli]
A41.52	Sepsis due to Pseudomonas
A41.53	Sepsis due to Serratia
A41.54	Sepsis due to Acinetobacter baumannii
A41.59	Other Gram-negative sepsis
A41.81	Sepsis due to Enterococcus
A41.89	Other specified sepsis
A41.9	Sepsis, unspecified organism

DRG Codes

8 rows

DRG Code	Description
791	Prematurity with Major Problems
793	Full Term Neonate with Major Problems
870	Septicemia or Severe Sepsis with MV >96 Hours
871	Septicemia or Severe Sepsis without MV >96 Hours with MCC
872	Septicemia or Severe Sepsis without MV >96 Hours without MCC
974	HIV with Major Related Condition with MCC
975	HIV with Major Related Condition with CC
976	HIV with Major Related Condition without CC/MCC

Typical Clinical Scenarios

An elderly nursing home resident with multiple comorbidities presents to the emergency department with sudden onset fever, hypotension, tachycardia, and altered mental status after a suspected urinary tract infection; blood cultures later grow Escherichia coli and the patient meets systemic inflammatory response criteria with organ dysfunction. A sepsis diagnosis from this group is assigned to capture the acute bloodstream infection and systemic response requiring IV antibiotics and hemodynamic support. Typical codes: A41.51, A41.9
A middle-aged patient hospitalized for severe community-acquired pneumonia develops new-onset respiratory failure and shock despite antibiotic therapy; cultures identify Staphylococcus aureus as the causative organism. Because the patient has a primary bacterial infection with systemic manifestations and organ dysfunction while inpatient, a code from this group is used to document sepsis due to the identified organism and guide severity coding. Typical codes: A41.01, A41.4
A postoperative immunocompromised oncology patient on chemotherapy develops low-grade fever and malaise over several days and is subsequently found to have a gram-negative bacteremia without a specified organism on initial testing; the sepsis diagnosis is recorded as a complicating comorbidity impacting ongoing cancer treatment and hospitalization. A nonspecific sepsis code from this group is assigned when the precise bacterial species is not identified or documented. Typical codes: A41.9, A41.5

Related Codes

A30-LEPROSY-HANSEN-S-DISEASE

ICD-10-CM Code For Leprosy Hansen's Disease: Group Overview

A31-INFECTION-DUE-TO-OTHER-MYCOBACTERIA

ICD-10-CM Code For Infection Due To Other Mycobacteria: Group Overview

A32-LISTERIOSIS

ICD-10-CM Code For Listeriosis: Group Overview

A33-TETANUS-NEONATORUM

ICD-10-CM Code For Tetanus Neonatorum: Group Overview

A34-OBSTETRICAL-TETANUS

ICD-10-CM Code For Obstetrical Tetanus: Group Overview

A35-OTHER-TETANUS

ICD-10-CM Code For Other Tetanus: Group Overview

A36-DIPHTHERIA

ICD-10-CM Code For Diphtheria: Group Overview

A37-WHOOPING-COUGH

ICD-10-CM Code For Whooping Cough: Group Overview

A38-SCARLET-FEVER

ICD-10-CM Code For Scarlet Fever: Group Overview

A39-MENINGOCOCCAL-INFECTION

ICD-10-CM Code For Meningococcal Infection: Group Overview

Showing 1–10 of 16

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-CM Code For Other Sepsis: Group Overview

Sign up for ICD-10-CM Code For Other Sepsis: Group Overview policy alerts

ICD-10-CM A41: Other Sepsis Overview

ICD-10-CM Code For Other Sepsis: Group Overview

Sign up for ICD-10-CM Code For Other Sepsis: Group Overview policy alerts

ICD-10-CM A41: Other Sepsis Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-CM codes are included in the A41 group for other sepsis?

How does coding within the `A41` group affect reimbursement?

Which related DRGs are commonly associated with sepsis codes in the `A41` group?

What clinical scenarios are represented by the `A41` group codes?

Are organism-specific and unspecified sepsis both included in the `A41` group?

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-CM codes are included in the A41 group for other sepsis?

How does coding within the `A41` group affect reimbursement?

Which related DRGs are commonly associated with sepsis codes in the `A41` group?

What clinical scenarios are represented by the `A41` group codes?

Are organism-specific and unspecified sepsis both included in the `A41` group?

References