CPT 81442: Genomic Panel for Noonan‑Spectrum Disorders
Commercial payers pay $1843 on average nationally for this procedure.
CPT code 81442 describes a genomic sequence analysis panel performed on a patient specimen to evaluate genetic sequences of at least 12 genes associated with Noonan-spectrum disorders (NSD); the service is a molecular diagnostic genomic sequencing panel typically performed in a clinical molecular laboratory or reference diagnostic laboratory and ordered for pediatric patients with developmental abnormalities such as congenital heart defects and characteristic craniofacial or skin findings.
For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, Genomic Profiling for Selecting Targeted Cancer Therapies.
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National Reimbursement Benchmarks
National commercial pricing for CPT 81442 centers around BUCA’s average commercial mean of $1,842.90, with individual payer means clustered above and below that mark. Blue Cross Blue Shield’s mean of $2,192.40 and Cigna’s mean of $2,009.00 sit above BUCA, while Aetna ($1,056.70) and UnitedHealth Group ($1,414.30) fall below. Maximums vary widely for some payers (e.g., Cigna $6,430.50, UnitedHealth Group $6,433.40, Blue Cross Blue Shield $6,254.00), reflecting occasional high negotiated rates but are not the primary focus for typical commercial activity.
Dispersion measured as the interquartile range (P75 minus P25) highlights how concentrated typical reimbursements are: Aetna has a range of $1,129.00, Blue Cross Blue Shield $980.30, BUCA $1,082.70, Cigna $1,544.00, and UnitedHealth Group $815.00. That makes UnitedHealth Group the tightest among these payers (IQR $815.00) and Cigna the widest (IQR $1,544.00), with BUCA’s IQR ($1,082.70) indicating moderate spread around its mean commercial rate.