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    v1.0.30
    OpenPayerBilling CodesDefinitive Drug Testing ProceduresCPT cpt-80372-tapentadol-drug-assay
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    CPT 80372: Tapentadol Detection/Quantitation

    CPT code 80372 describes laboratory testing in which a lab analyst measures the amount of or detects the presence of tapentadol, a centrally acting opioid analgesic, in a patient specimen; this is a drug quantitation/detection service typically performed by clinical laboratories and hospital labs and reported as a laboratory test of a patient specimen collected in outpatient, inpatient, or emergency settings.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A 42-year-old patient with chronic neuropathic back pain treated with tapentadol presents for routine monitoring and for suspected nonadherence or possible diversion. The prescribing clinician orders a targeted urine or serum toxicology assay to detect and quantify tapentadol to confirm recent ingestion, assess therapeutic levels, or investigate unexpected clinical findings such as worsening pain, signs of sedation, or inconsistent pill counts. The specimen is collected at an outpatient laboratory or hospital clinical laboratory; the specimen is labeled and accompanied by the clinician's order. The laboratory performs a specific analytical assay for tapentadol — typically liquid chromatography with tandem mass spectrometry (LC-MS/MS) or an immunoassay followed by confirmatory testing — and reports qualitative or quantitative results to the ordering clinician. Results inform clinical decisions about ongoing opioid therapy, risk mitigation, or further toxicology evaluation. Typical sites of service are outpatient laboratories, hospital inpatient or outpatient laboratories, and emergency departments when acute overdose or toxicity is suspected.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80372Drug assay, tapentadol; qualitative or quantitativePrimary code describing the laboratory analytic measurement of tapentadol in a patient specimen
    80307Drug confirmation, any number of drugs, using chromatography/mass spectrometry; by reportOften used for confirmatory testing when initial screening is positive and confirmation by LC-MS/MS is required
    80320Ethanol and/or metabolites; qualitativeMay be ordered concurrently in cases of suspected mixed-substance ingestion or impairment evaluation
    81002Urinalysis, by dipstick, non-automated, without microscopyCommon preanalytic or concurrent test when collecting urine specimens to document specimen validity and concentration
    80365Toxicology assay, opiate metabolites, quantitative, by gas chromatography/mass spectrometry (GC/MS) or LC/MS/MSAlternative or additional confirmatory test when comprehensive opioid metabolite quantification is needed

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    208D00000X
    207L00000X
    363L00000X
    2472E0500X
    2472B0301X
    152WS0006X
    207RN0300X

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    F11.10Opioid abuse, uncomplicated
    F11.20Opioid dependence, uncomplicated
    F11.21Opioid dependence, in remission
    F33.1Major depressive disorder, recurrent, moderate
    F41.1Generalized anxiety disorder
    F45.41Pain disorder exclusively related to psychological factors
    G47.00Insomnia, unspecified
    G89.0Central pain syndrome
    G89.3Neoplasm related pain (acute) (chronic)
    G89.4Chronic pain syndrome

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-80320-ALCOHOL-DETECTION-IN-SPECIMEN

    CPT 80320: Alcohol Detection and Quantification

    CPT-80321-ALCOHOL-BIOMARKER-ASSAY

    CPT 80321: Alcohol Biomarker Assay, One or Two Compounds

    CPT-80322-ALCOHOL-BIOMARKER-PANEL-MULTI-ANALYTE

    CPT 80322: Alcohol Biomarker Panel, Three or More Compounds

    CPT-80323-ALKALOID-DRUG-LEVEL-ANALYSIS

    CPT 80323: Alkaloid Drug Identification and Quantitation

    CPT-80324-AMPHETAMINE-DRUG-TESTING-LAB-ASSAY

    CPT 80324: Amphetamine Detection and Quantification

    CPT-80325-AMPHETAMINES-DETECTION-AND-QUANTIFICATION

    CPT 80325: Detection of Three or Four Amphetamines

    CPT-80326-AMPHETAMINES-PANEL-5-OR-MORE

    CPT 80326: Detection/Quantification of Five or More Amphetamines

    CPT-80334-SEROTONERGIC-ANTIDEPRESSANT-PANEL

    CPT 80334: Detection of Six or More Serotonergic Antidepressants

    CPT-80335-TRICYCLIC-ANTIDEPRESSANT-ASSAY

    CPT 80335: Tricyclic and Cyclical Antidepressant Assay

    CPT-80344-MULTI-ANTIPSYCHOTIC-PANEL-SEVEN-PLUS-DRUGS

    CPT 80344: Multiplex Antipsychotic Drug Detection (7+ agents)

    Showing 1–10 of 24

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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