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    v1.0.30
    OpenPayerBilling CodesDefinitive Drug Testing ProceduresCPT cpt-80334-serotonergic-antidepressant-panel
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    CPT 80334: Detection of Six or More Serotonergic Antidepressants

    CPT code 80334 describes a laboratory test that detects and/or measures six or more serotonergic antidepressant medications in a patient specimen; the service is a multi-analyte toxicology/therapeutic drug monitoring assay performed in a clinical laboratory or reference lab and is typically ordered by behavioral health, psychiatry, or primary care clinicians to assess medication adherence or exposure.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A 42-year-old patient with a history of major depressive disorder and recent changes in medication presents to an outpatient behavioral health clinic after partial response to therapy and concern for polypharmacy and drug interactions. The treating psychiatrist orders a comprehensive toxicology panel specifically to measure or detect six or more serotonergic antidepressants in the patient’s blood to confirm adherence, identify potential serotonergic exposure, and evaluate risk for serotonin syndrome. The specimen is collected in the clinic or a phlebotomy collection center and sent to a clinical laboratory with toxicology capabilities. The lab analyst performs a multi-analyte assay (qualitative and/or quantitative) that detects the presence and relative amounts of multiple serotonergic antidepressants and documents findings in the laboratory information system. Results are returned to the ordering clinician for medication reconciliation and management decisions.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80307Drug test(s), presumptive, any number of drug classes, any number of devices or procedures, capable of being read by direct optical observation (e.g., dipsticks, cups, cards), per date of serviceMay be used as an initial point-of-care presumptive screen prior to sending specimens for confirmatory multi-analyte serotonergic antidepressant testing.
    80336Drug test(s), definitive, any number of drug classes; quantitative, via chromatographic techniques, each drug class (e.g., LC-MS, GC-MS)Used for definitive quantitative confirmation when individual drug quantitation by chromatographic-mass spectrometry is required alongside or instead of the multi-analyte panel.
    80337Drug test(s), definitive, any number of drug classes; qualitative or quantitative, confirmatory, each drug classApplicable for confirmatory testing of specific serotonergic agents identified on the multi-analyte assay.
    80104Drug test(s), definitive, each method; not otherwise specified (older coding for comprehensive testing)Historically used for broad confirmatory testing; may be billed in some lab workflows depending on payer rules.
    81025Urine pregnancy test, by visual color comparison methodsOften performed concurrently in women of childbearing potential before adjusting or initiating serotonergic medications.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207R00000X
    207L00000X
    363L00000X
    163WC2100X
    207ZM0300X
    2084N0600X
    163WS0121X
    2084F0202X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    F06.30Mood disorder due to known physiological condition, unspecified
    F06.4Anxiety disorder due to known physiological condition
    F10.20Alcohol dependence, uncomplicated
    F11.20Opioid dependence, uncomplicated
    F32.1Major depressive disorder, single episode, moderate
    F32.9Major depressive disorder, single episode, unspecified
    F33.1Major depressive disorder, recurrent, moderate
    F33.2Major depressive disorder, recurrent severe without psychotic features
    F33.9Major depressive disorder, recurrent, unspecified
    F34.1Dysthymic disorder

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-80320-ALCOHOL-DETECTION-IN-SPECIMEN

    CPT 80320: Alcohol Detection and Quantification

    CPT-80321-ALCOHOL-BIOMARKER-ASSAY

    CPT 80321: Alcohol Biomarker Assay, One or Two Compounds

    CPT-80322-ALCOHOL-BIOMARKER-PANEL-MULTI-ANALYTE

    CPT 80322: Alcohol Biomarker Panel, Three or More Compounds

    CPT-80323-ALKALOID-DRUG-LEVEL-ANALYSIS

    CPT 80323: Alkaloid Drug Identification and Quantitation

    CPT-80324-AMPHETAMINE-DRUG-TESTING-LAB-ASSAY

    CPT 80324: Amphetamine Detection and Quantification

    CPT-80325-AMPHETAMINES-DETECTION-AND-QUANTIFICATION

    CPT 80325: Detection of Three or Four Amphetamines

    CPT-80326-AMPHETAMINES-PANEL-5-OR-MORE

    CPT 80326: Detection/Quantification of Five or More Amphetamines

    CPT-80335-TRICYCLIC-ANTIDEPRESSANT-ASSAY

    CPT 80335: Tricyclic and Cyclical Antidepressant Assay

    CPT-80344-MULTI-ANTIPSYCHOTIC-PANEL-SEVEN-PLUS-DRUGS

    CPT 80344: Multiplex Antipsychotic Drug Detection (7+ agents)

    CPT-80345-BARBITURATE-DETECTION-SERUM-URINE

    CPT 80345: Barbiturate Detection in Serum or Urine

    Showing 1–10 of 24

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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