CPT 80325 Amphetamines — Reimbursement & Policy | OpenPayer

Summary & Overview

CPT 80325: Amphetamines Detection and Quantification

CPT code 80325 denotes a laboratory assay that detects or quantifies three or four amphetamines in a patient specimen. This laboratory toxicology test plays a role in clinical care, occupational health, substance use evaluation, and medication monitoring, and it is relevant to clinicians, laboratories, and payers nationwide. Coverage and reimbursement policies for amphetamine testing affect access to testing and laboratory workflows across outpatient and inpatient settings.

Key payers referenced in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find an overview of the clinical context for amphetamine testing, common billing modifiers and service line considerations, and national benchmarks where available. The publication summarizes typical sites of service and service type, outlines payer coverage presence, and highlights areas where policy updates or coding clarifications could affect clinical and billing operations. Data not available in the input is noted where applicable.

AetnaBlue Cross Blue ShieldCigna HealthUnitedHealthcareMedicareCPT 80325toxicologyamphetamineslaboratoryclinical pathologydrug testingtoxicology assaylaboratory billingspecimen testing

Billing Code Overview

CPT code 80325 measures the amount of, or detects the presence of, three or four amphetamines in a patient specimen. This test evaluates central nervous system stimulant compounds and is used to identify amphetamine exposure or quantify levels when clinically indicated.

Service type: Clinical laboratory toxicology assay
Typical site of service: Hospital or independent clinical laboratory, outpatient laboratory collection sites, and medically supervised testing facilities

Data not available in the input.

Clinical & Coding Specifications

Clinical Context

A 28-year-old adult presents to an outpatient addiction medicine clinic for urine drug testing as part of routine monitoring of a stimulant-use disorder treatment program. The patient is enrolled in a workplace safety testing panel and reports current prescription amphetamine therapy for attention-deficit/hyperactivity disorder. A urine specimen is collected and sent to the clinical laboratory. The laboratory performs a qualitative screen and reflexes to confirmatory testing using an assay that measures the presence and/or amount of three or four amphetamines in the specimen. Results are documented in the patient record and communicated to the ordering clinician for medication management, compliance monitoring, or occupational safety decisions.

Typical site of service: Clinical laboratory, hospital laboratory, outpatient clinic with laboratory services, or reference diagnostic laboratory.

Service type: Clinical toxicology laboratory assay for amphetamines detection/quantitation as described by 80325.

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when billing for the professional interpretation of the laboratory test separate from the technical component.

CPT 80367: Propoxyphene Detection in Patient Specimen

CPT-80345-BARBITURATE-DETECTION-SERUM-URINE

CPT 80345: Barbiturate Detection in Serum or Urine

CPT-80347-BENZODIAZEPINE-PANEL-13-PLUS

CPT 80347: Benzodiazepine Panel, 13+ Analytes

CPT-80320-ALCOHOL-DETECTION-IN-SPECIMEN

CPT 80320: Alcohol Detection in Patient Specimens

CPT-80361-OPIATE-NARCOTIC-TOXICOLOGY-ANALYSIS

CPT 80361: Opiate and Narcotic Analgesic Toxicology Analysis

CPT-80370-MULTIPLE-SKELETAL-MUSCLE-RELAXANT-PANEL

CPT 80370: Detection of Three or More Skeletal Muscle Relaxants

CPT-80359-METHYLENEDIOXYAMPHETAMINES-ASSAY

CPT 80359: Methylenedioxyamphetamines Measurement or Detection

CPT-80323-ALKALOID-DRUG-LEVEL-ANALYSIS

CPT 80323: Alkaloid Drug Level Analysis

CPT-80321-ALCOHOL-BIOMARKER-ASSAY

CPT 80321: Alcohol Biomarker Detection and Measurement

CPT-80326-AMPHETAMINES-PANEL-5-OR-MORE

CPT 80326: Multi‑Amphetamine Toxicology Panel

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Taxonomy Code	Specialty	Notes
`207Q00000X`	Clinical Pathology	Primary specialty performing and interpreting toxicology assays.
`207RP1001X`	Clinical Laboratory Scientist	Professionals who perform and validate laboratory assays.
`208D00000X`	Medical Toxicology	Specialists who may interpret complex toxicology results in clinical context.
`207L00000X`	Clinical Laboratory Director	Oversees laboratory quality and reporting of toxicology testing.
`207K00000X`	Pathology-Anatomic & Clinical	Pathologists who may supervise and sign out specialized toxicology testing.

ICD-10 Code	Description	Clinical Relevance
Data not available in the input.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80300`	Drug test(s), presumptive, any number of drug classes; any number of devices or procedures, capable of being read by direct optical observation (e.g., dipsticks, cups, cards)	Often used as an initial point-of-care presumptive screen before sending a specimen for confirmatory `80325` testing.
`80307`	Drug test(s), presumptive, multiple drug classes by instrumented chemistry analyzers, each procedure	Instrumented laboratory screens that may precede or complement `80325` confirmatory assays.
`80305`	Drug screen, presumptive, any number of drug classes by a chromatographic method	Alternative or additional screening methods in the laboratory workflow prior to confirmatory testing.
`80101`	Drug confirmation, qualitative or quantitative, single drug class by confirmatory methods (e.g., GC/MS) — note: specific codes vary by analyte	Other confirmation codes commonly used for GC/MS or LC-MS/MS confirmation when higher specificity or quantitation is required alongside `80325`.
`81025`	Urine pregnancy test, by visual color comparison methods	Ancillary laboratory test commonly performed on the same specimen or in parallel for clinical decision-making in reproductive-age patients undergoing toxicology testing.

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