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CPT 80322: Alcohol Biomarker Panel, Multi-Analyte

CPT code 80322 designates a laboratory assay that detects and quantifies three or more alcohol biomarker compounds in a patient specimen. Such multi-analyte alcohol biomarker testing is used to identify recent or ongoing alcohol exposure, support clinical diagnosis, monitor treatment or abstinence, and inform forensic or occupational evaluations. Nationally, standardized coding for multi-analyte alcohol biomarker panels enables clearer billing, clinical communication, and surveillance of alcohol-related testing patterns.

Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context and service settings, common modifiers and billing notes, and what typical coverage patterns and payer engagement look like for laboratory biomarker tests. The publication summarizes benchmarks where available, highlights billing and coding considerations for laboratories and clinicians, and outlines implications for clinical workflows and reporting. Data not available in the input for associated taxonomies, ICD-10 diagnoses, and related codes are noted as not provided.

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Billing Code Overview

CPT code 80322 describes a laboratory service in which a lab analyst detects and measures alcohol biomarkers in a patient specimen. Alcohol biomarkers are physiological indicators of alcohol exposure or ingestion. This particular test covers analysis for three or more alcohol biomarker compounds, providing a multi-analyte assessment of alcohol use or recent exposure.

Service type: Clinical laboratory toxicology/biomarker testing

Typical site of service: Clinical laboratory or hospital laboratory, with specimens collected in outpatient clinics, physician offices, inpatient settings, or specialized testing centers.

Find policies, billing codes, payers, states, and providers

CPT 80322: Alcohol Biomarker Panel, Multi-Analyte

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Get alerted when payer policies referencing 80322 are released or updated.

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Billing Code Overview

Service type: Clinical laboratory toxicology/biomarker testing

Typical site of service: Clinical laboratory or hospital laboratory, with specimens collected in outpatient clinics, physician offices, inpatient settings, or specialized testing centers.

Clinical & Coding Specifications

Clinical Context

A 38-year-old adult presents to an outpatient toxicology laboratory after referral from occupational health and a primary care provider who suspects recent alcohol exposure or heavy drinking. The provider orders an alcohol biomarker panel to detect and quantify multiple alcohol-related metabolites in a blood specimen to support occupational fitness-for-duty evaluation, treatment monitoring in an alcohol-use disorder program, or medico-legal confirmation of recent ingestion. The patient arrives at a clinical laboratory draw station; phlebotomy obtains a blood sample, which is accessioned and sent to the clinical chemistry/toxicology lab. The laboratory analyst performs multi-analyte testing for three or more alcohol biomarker compounds (for example, ethyl glucuronide, ethyl sulfate, phosphatidylethanol) using validated analytical methods, documents results in the laboratory information system, and issues a report to the ordering clinician. Typical sites of service include outpatient clinical laboratories, hospital laboratory departments, and specialized toxicology reference labs. Results inform clinical management, occupational decisions, or program compliance monitoring and are interpreted alongside clinical history and other testing (e.g., breathalyzer, serum ethanol).

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when billing only the professional interpretation component of the test separate from technical services.
`52`	Reduced services	Use when the test is partially performed or limited in scope compared with the full-service procedure.
`53`	Discontinued procedure	Use when testing was started but discontinued for reasons beyond provider control before completion.
`55`	Postoperative management only	Rare for this lab test; use if billing relates solely to postoperative management when applicable.
`56`	Preoperative management only	Use if test is ordered and billed as part of preoperative evaluation only.
`62`	Two surgeons	Use when two qualified providers share responsibility for service-level oversight in complex institutional testing arrangements.
`78`	Unplanned return to OR	Typically not applicable; include when applicable in a concurrent surgical context.
`80`	Assistant surgeon	Not usually applicable; include where an assistant clinician provided a billable portion of service oversight.
`90`	Reference (outside) laboratory	Use when the specimen is sent to an outside reference laboratory for testing and the ordering lab bills for the service.
`TC`	Technical component	Use when billing only the technical component (laboratory processing, instrumentation) of the test.
`QX`	CLIA-waived/waived test performed by non-lab personnel under CLIA? (Modifier QX indicates service performed by a nonphysician practitioner with their own QHP number)	Use when a qualified non-physician practitioner performs the test under their identifier as allowed.
`QY`	Services ordered by a physician but performed by an independent laboratory	Use when an independent lab performs the testing per another provider's order.
`AS`	Physician assistant, nurse practitioner, or clinical nurse specialist services	Use when those midlevel providers are performing or ordering and billing under their identifiers where allowed.
`90`	Reference (duplicate entry avoided)	Use as above for outside reference lab billing.

Taxonomy Code	Specialty	Notes
207Q00000X	Anatomic and Clinical Pathology	Clinical chemists and pathologists oversee toxicology testing and result interpretation.
208D00000X	Clinical Laboratory	Laboratory directors and clinical laboratory scientists manage and perform analytic testing.
363L00000X	Toxicology	Specialists focused on toxicology testing, method validation, and interpretation.
208000000X	Medical Laboratory Technician/Technologist	Technologists perform specimen processing and instrument operation for biomarker assays.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`F10.20`	Alcohol dependence, uncomplicated	Common indication for biomarker monitoring to assess ongoing alcohol exposure during treatment.
`F10.21`	Alcohol dependence, in remission	Used when confirming abstinence in remission monitoring programs.
`F10.10`	Alcohol abuse, uncomplicated	Biomarkers assist in detecting recent ingestion in patients with alcohol abuse.
`R78.0`	Finding of alcohol in blood	Directly related to laboratory confirmation of alcohol biomarkers and exposure.
`Z13.89`	Encounter for screening for other specified diseases and disorders	Used for workplace or programmatic screening that includes alcohol biomarker panels.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`36415`	Collection of venous blood by venipuncture	Performed before `80322` to obtain the blood specimen for alcohol biomarker testing.
`80307`	Ethyl alcohol; qualitative or quantitative (breath testing not included) — note: single-analyte testing	May be performed in parallel when single alcohol analyte measurement is required in addition to multi-marker panels.
`82570`	Drug assay, presumptive, any number of drug classes; urine	Frequently ordered alongside blood alcohol biomarkers for comprehensive substance use screening; different specimen type.
`80301`	Drug test(s), presumptive, any number of drug classes; urine, non-quantitative	Used in broader toxicology screening workflows paired with confirmatory alcohol biomarker testing.
`G0477`	Drug screen confirmation by definitive methodologies (e.g., GC/MS, LC/MS/MS)	Used when definitive confirmation of alcohol biomarkers or metabolites is required following initial panel testing.

Related Codes

CPT-80320-ALCOHOL-DETECTION-IN-SPECIMEN

CPT 80320: Alcohol Detection in Patient Specimens

CPT-80321-ALCOHOL-BIOMARKER-ASSAY

CPT 80321: Alcohol Biomarker Detection and Measurement

CPT-80323-ALKALOID-DRUG-LEVEL-ANALYSIS

CPT 80323: Alkaloid Drug Level Analysis

CPT-80324-AMPHETAMINE-DRUG-TESTING-LAB-ASSAY

CPT 80324: Amphetamine Detection/Quantification in Patient Specimen

CPT-80325-AMPHETAMINES-DETECTION-AND-QUANTIFICATION

CPT 80325: Amphetamines Detection and Quantification

CPT-80326-AMPHETAMINES-PANEL-5-OR-MORE

CPT 80326: Multi‑Amphetamine Toxicology Panel

CPT-80334-SEROTONERGIC-ANTIDEPRESSANT-PANEL

CPT 80334: Multi-Analyte Serotonergic Antidepressant Panel

CPT-80335-TRICYCLIC-ANTIDEPRESSANT-ASSAY

CPT 80335: Assay for Tricyclic and Cyclical Antidepressants

CPT-80344-MULTI-ANTIPSYCHOTIC-PANEL-SEVEN-PLUS-DRUGS

CPT 80344: Multi‑analyte Antipsychotic Test, Seven or More Drugs

CPT-80345-BARBITURATE-DETECTION-SERUM-URINE

CPT 80345: Barbiturate Detection in Serum or Urine

Showing 1–10 of 24

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when billing only the professional interpretation component of the test separate from technical services.
`52`	Reduced services	Use when the test is partially performed or limited in scope compared with the full-service procedure.
`53`	Discontinued procedure	Use when testing was started but discontinued for reasons beyond provider control before completion.
`55`	Postoperative management only	Rare for this lab test; use if billing relates solely to postoperative management when applicable.
`56`	Preoperative management only	Use if test is ordered and billed as part of preoperative evaluation only.
`62`	Two surgeons	Use when two qualified providers share responsibility for service-level oversight in complex institutional testing arrangements.
`78`	Unplanned return to OR	Typically not applicable; include when applicable in a concurrent surgical context.
`80`	Assistant surgeon	Not usually applicable; include where an assistant clinician provided a billable portion of service oversight.
`90`	Reference (outside) laboratory	Use when the specimen is sent to an outside reference laboratory for testing and the ordering lab bills for the service.
`TC`	Technical component	Use when billing only the technical component (laboratory processing, instrumentation) of the test.
`QX`	CLIA-waived/waived test performed by non-lab personnel under CLIA? (Modifier QX indicates service performed by a nonphysician practitioner with their own QHP number)	Use when a qualified non-physician practitioner performs the test under their identifier as allowed.
`QY`	Services ordered by a physician but performed by an independent laboratory	Use when an independent lab performs the testing per another provider's order.
`AS`	Physician assistant, nurse practitioner, or clinical nurse specialist services	Use when those midlevel providers are performing or ordering and billing under their identifiers where allowed.
`90`	Reference (duplicate entry avoided)	Use as above for outside reference lab billing.

Taxonomy Code	Specialty	Notes
207Q00000X	Anatomic and Clinical Pathology	Clinical chemists and pathologists oversee toxicology testing and result interpretation.
208D00000X	Clinical Laboratory	Laboratory directors and clinical laboratory scientists manage and perform analytic testing.
363L00000X	Toxicology	Specialists focused on toxicology testing, method validation, and interpretation.
208000000X	Medical Laboratory Technician/Technologist	Technologists perform specimen processing and instrument operation for biomarker assays.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`F10.20`	Alcohol dependence, uncomplicated	Common indication for biomarker monitoring to assess ongoing alcohol exposure during treatment.
`F10.21`	Alcohol dependence, in remission	Used when confirming abstinence in remission monitoring programs.
`F10.10`	Alcohol abuse, uncomplicated	Biomarkers assist in detecting recent ingestion in patients with alcohol abuse.
`R78.0`	Finding of alcohol in blood	Directly related to laboratory confirmation of alcohol biomarkers and exposure.
`Z13.89`	Encounter for screening for other specified diseases and disorders	Used for workplace or programmatic screening that includes alcohol biomarker panels.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`36415`	Collection of venous blood by venipuncture	Performed before `80322` to obtain the blood specimen for alcohol biomarker testing.
`80307`	Ethyl alcohol; qualitative or quantitative (breath testing not included) — note: single-analyte testing	May be performed in parallel when single alcohol analyte measurement is required in addition to multi-marker panels.
`82570`	Drug assay, presumptive, any number of drug classes; urine	Frequently ordered alongside blood alcohol biomarkers for comprehensive substance use screening; different specimen type.
`80301`	Drug test(s), presumptive, any number of drug classes; urine, non-quantitative	Used in broader toxicology screening workflows paired with confirmatory alcohol biomarker testing.
`G0477`	Drug screen confirmation by definitive methodologies (e.g., GC/MS, LC/MS/MS)	Used when definitive confirmation of alcohol biomarkers or metabolites is required following initial panel testing.

Related Codes

CPT-80320-ALCOHOL-DETECTION-IN-SPECIMEN

CPT 80320: Alcohol Detection in Patient Specimens

CPT-80321-ALCOHOL-BIOMARKER-ASSAY

CPT 80321: Alcohol Biomarker Detection and Measurement

CPT-80323-ALKALOID-DRUG-LEVEL-ANALYSIS

CPT 80323: Alkaloid Drug Level Analysis

CPT-80324-AMPHETAMINE-DRUG-TESTING-LAB-ASSAY

CPT 80324: Amphetamine Detection/Quantification in Patient Specimen

CPT-80325-AMPHETAMINES-DETECTION-AND-QUANTIFICATION

CPT 80325: Amphetamines Detection and Quantification

CPT-80326-AMPHETAMINES-PANEL-5-OR-MORE

CPT 80326: Multi‑Amphetamine Toxicology Panel

CPT-80334-SEROTONERGIC-ANTIDEPRESSANT-PANEL

CPT 80334: Multi-Analyte Serotonergic Antidepressant Panel

CPT-80335-TRICYCLIC-ANTIDEPRESSANT-ASSAY

CPT 80335: Assay for Tricyclic and Cyclical Antidepressants

CPT-80344-MULTI-ANTIPSYCHOTIC-PANEL-SEVEN-PLUS-DRUGS

CPT 80344: Multi‑analyte Antipsychotic Test, Seven or More Drugs

CPT-80345-BARBITURATE-DETECTION-SERUM-URINE

CPT 80345: Barbiturate Detection in Serum or Urine

Showing 1–10 of 24

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

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CPT 80322: Alcohol Biomarker Panel, Multi-Analyte

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Billing Code Overview

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CPT 80322: Alcohol Biomarker Panel, Multi-Analyte

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Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

CPT 80322: Alcohol Biomarker Panel, Multi-Analyte

Sign up for cpt 80322 policy alerts

Billing Code Overview

CPT 80322: Alcohol Biomarker Panel, Multi-Analyte

Sign up for cpt 80322 policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What does CPT 80322 represent?

Where is the 80322 test typically performed and how is the specimen obtained?

Which billing modifiers are commonly used with CPT 80322?

What other CPT codes are commonly billed with or related to 80322?

What clinical indications or ICD-10 diagnoses are associated with ordering 80322?

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What does CPT 80322 represent?

Where is the 80322 test typically performed and how is the specimen obtained?

Which billing modifiers are commonly used with CPT 80322?

What other CPT codes are commonly billed with or related to 80322?

What clinical indications or ICD-10 diagnoses are associated with ordering 80322?

References