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    v1.0.30
    OpenPayerBilling CodesDefinitive Drug Testing ProceduresCPT cpt-80344-multi-antipsychotic-panel-seven-plus-drugs
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    CPT 80344: Multiplex Antipsychotic Drug Detection (7+ agents)

    CPT code 80344 describes a laboratory test that measures or detects the presence of seven or more antipsychotic medications in a patient specimen; the service is a qualitative and/or quantitative multiplex toxicology analysis for antipsychotics typically performed as a laboratory diagnostic service in clinical laboratories or hospital laboratory settings to assess exposure, adherence, or potential toxicity from antipsychotic agents.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A psychiatric outpatient or inpatient medically supervised setting orders a comprehensive urine or serum toxicology screen when a patient receiving antipsychotic therapy presents with non‑adherence concerns, unusual symptoms, suspected overdose, drug interactions, or needs therapeutic drug monitoring. A 30‑year‑old patient with schizophrenia admitted for acute psychosis has persistent agitation despite reported adherence; the treating team orders a broad antipsychotic panel to detect presence and approximate levels of seven or more antipsychotic agents. The sample is collected in the clinical laboratory, processed by a qualified lab analyst, and analyzed using mass spectrometry or immunoassay methods capable of detecting multiple antipsychotic agents. Results are reviewed by the laboratory and transmitted to the treating clinician to inform medication reconciliation, toxicity assessment, or forensic/medicolegal documentation. Typical sites of service include hospital inpatient laboratories, outpatient hospital-based labs, independent clinical laboratories, and large reference laboratories supporting emergency departments and behavioral health clinics.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80307Amphetamines, single class drug screen; presumptive, any number of drug classesCommon preliminary or complementary presumptive drug screen performed in emergency or outpatient settings prior to or alongside targeted antipsychotic panels
    80305Drug test, presumptive, any number of drug classes; multiple drug classes by instrumented chemistry analyzersUsed when broad presumptive screening is needed before definitive multianalyte antipsychotic testing
    80377Drug confirmation, quantitative, each specimen; toxicology (e.g., LC/MS/MS), includes analyte-specific confirmationCommonly used for confirmatory quantitative testing of specific antipsychotic agents identified on a multianalyte panel
    81025Urine pregnancy test, by visual color comparison methodsFrequently performed concurrently for women of childbearing potential when medication changes are considered
    36415Collection of venous blood by venipunctureVenipuncture for serum or plasma specimens often performed prior to laboratory antipsychotic testing

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208100000X
    207ZP0007X
    385H00000X
    207LC0200X
    174H00000X
    363L00000X
    163WX0003X
    163WN1003X

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-80320-ALCOHOL-DETECTION-IN-SPECIMEN

    CPT 80320: Alcohol Detection and Quantification

    CPT-80321-ALCOHOL-BIOMARKER-ASSAY

    CPT 80321: Alcohol Biomarker Assay, One or Two Compounds

    CPT-80322-ALCOHOL-BIOMARKER-PANEL-MULTI-ANALYTE

    CPT 80322: Alcohol Biomarker Panel, Three or More Compounds

    CPT-80323-ALKALOID-DRUG-LEVEL-ANALYSIS

    CPT 80323: Alkaloid Drug Identification and Quantitation

    CPT-80324-AMPHETAMINE-DRUG-TESTING-LAB-ASSAY

    CPT 80324: Amphetamine Detection and Quantification

    CPT-80325-AMPHETAMINES-DETECTION-AND-QUANTIFICATION

    CPT 80325: Detection of Three or Four Amphetamines

    CPT-80326-AMPHETAMINES-PANEL-5-OR-MORE

    CPT 80326: Detection/Quantification of Five or More Amphetamines

    CPT-80334-SEROTONERGIC-ANTIDEPRESSANT-PANEL

    CPT 80334: Detection of Six or More Serotonergic Antidepressants

    CPT-80335-TRICYCLIC-ANTIDEPRESSANT-ASSAY

    CPT 80335: Tricyclic and Cyclical Antidepressant Assay

    CPT-80345-BARBITURATE-DETECTION-SERUM-URINE

    CPT 80345: Barbiturate Detection in Serum or Urine

    Showing 1–10 of 24

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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