Summary & Overview
CPT 80344: Multi‑analyte Antipsychotic Test, Seven or More Drugs
Headline: CPT code 80344: Multi‑analyte antipsychotic panel for seven or more drugs
Lead: CPT code 80344 identifies a laboratory procedure for detecting or quantifying seven or more antipsychotic medications in a patient specimen. The code supports care coordination, medication safety, and forensic or compliance uses where broad antipsychotic screening is required.
CPT code 80344 represents comprehensive toxicology testing for antipsychotic medications when multiple agents must be assessed beyond single‑drug panels. Nationally, the code is relevant for inpatient and outpatient laboratories, behavioral health programs, and clinical toxicology services because it informs treatment decisions, monitors adherence or misuse, and supports medication reconciliation. Key payers addressed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare.
Readers will learn the clinical context for ordering broad antipsychotic testing, the typical sites of service and service type, and which major payers commonly process claims for this testing. The publication also summarizes typical modifier usage (input provided), common operational settings for performing the test, and notes where input data were unavailable. Data not available in the input are identified as such rather than inferred.
Billing Code Overview
CPT code 80344 describes a laboratory test in which the analyst measures or detects the presence of seven or more antipsychotic medications in a patient specimen. Antipsychotics are medications used to treat psychosis and other mental or emotional disorders. The code covers multi-analyte testing for antipsychotic drugs when those analytes are not specified under other CPT codes.
Service type: Laboratory—toxicology/drug monitoring panel
Typical site of service: Clinical laboratory, hospital laboratory, or outpatient specimen collection site
Clinical & Coding Specifications
Clinical Context
A psychiatric outpatient or inpatient medically supervised setting orders a comprehensive urine or serum toxicology screen when a patient receiving antipsychotic therapy presents with non‑adherence concerns, unusual symptoms, suspected overdose, drug interactions, or needs therapeutic drug monitoring. A 30‑year‑old patient with schizophrenia admitted for acute psychosis has persistent agitation despite reported adherence; the treating team orders a broad antipsychotic panel to detect presence and approximate levels of seven or more antipsychotic agents. The sample is collected in the clinical laboratory, processed by a qualified lab analyst, and analyzed using mass spectrometry or immunoassay methods capable of detecting multiple antipsychotic agents. Results are reviewed by the laboratory and transmitted to the treating clinician to inform medication reconciliation, toxicity assessment, or forensic/medicolegal documentation. Typical sites of service include hospital inpatient laboratories, outpatient hospital-based labs, independent clinical laboratories, and large reference laboratories supporting emergency departments and behavioral health clinics.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
00 | Default/No modifier | When no specific modifier applies to the billed service |
26 |