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    v1.0.30
    OpenPayerBilling CodesDefinitive Drug Testing ProceduresCPT cpt-80367-propoxyphene-detection-toxicology-test
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    CPT 80367: Propoxyphene Detection in Patient Specimen

    CPT code 80367 describes laboratory testing that detects or measures propoxyphene, a narcotic analgesic, in a patient specimen; the service is a toxicology/drug detection laboratory procedure typically performed in clinical laboratories or hospital lab facilities on blood or urine samples.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A middle-aged outpatient presents to a hospital or independent clinical laboratory for urine or blood toxicology testing requested by the treating clinician to assess recent opioid exposure and to confirm or exclude use of the specific analgesic propoxyphene. The patient may be evaluated for altered mental status in the emergency department, for suspected opioid-related adverse effects in an inpatient ward, or as part of a preoperative or pain-management program requiring medication monitoring. A clinician orders a targeted assay for propoxyphene when the medication history, pill bottle, prescription record, or clinical presentation suggests possible ingestion. The specimen (urine or serum) is collected according to laboratory chain-of-custody and stability protocols, transported to the laboratory, and processed by qualified laboratory personnel. The lab analyst performs a specific qualitative or quantitative assay to detect the presence of propoxyphene (or its metabolites) and documents results in the laboratory information system. Results are reported to the ordering clinician and incorporated into clinical decision-making such as toxicology interpretation, medication reconciliation, or perioperative clearance. Typical sites of service include hospital laboratories, independent clinical diagnostic laboratories, and larger ambulatory or outpatient laboratory collection centers.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80305Drug test(s), presumptive, any number of drug classes; any number of devices or procedures, capable of being read visually (e.g., immunoassay)Common screening test performed before or alongside a targeted confirmatory assay for specific drugs such as propoxyphene.
    80320Drug confirmation, qualitative or quantitative, multiple drug classes by mass spectrometry, each specimen; e.g., gas or liquid chromatography with mass spectrometry (GC-MS or LC-MS)A confirmatory methodology often used when 80367 (specific propoxyphene assay) requires definitive confirmation or quantitation.
    G0480Toxicology testing, definitive, for drugs of abuse, any number of specimens, 1-7 drug classes (Note: G-codes are applicable for certain payers and programs)May be used for payer-specific billing of definitive toxicology testing in broader panels that include propoxyphene.
    81002Urinalysis, non-automated, without microscopySpecimen evaluation commonly performed at collection to assess specimen integrity and concentration prior to specific drug testing.
    36415Collection of venous blood by venipunctureCommonly performed when serum quantitation of propoxyphene is required instead of urine.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    208D00000X
    207R00000X
    103TA0700X
    246QC1000X
    364SC0200X
    152WC0802X
    2086H0002X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    F11.10Opioid abuse, uncomplicated
    F11.129Opioid abuse with intoxication, unspecified
    F11.20Opioid dependence, uncomplicated
    G89.29Other chronic pain
    G89.3Neoplasm related pain (acute) (chronic)
    G89.4Chronic pain syndrome
    M16.9Osteoarthritis of hip, unspecified
    M17.9Osteoarthritis of knee, unspecified
    M25.50Pain in unspecified joint
    M51.26Other intervertebral disc displacement, lumbar region

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-80320-ALCOHOL-DETECTION-IN-SPECIMEN

    CPT 80320: Alcohol Detection and Quantification

    CPT-80321-ALCOHOL-BIOMARKER-ASSAY

    CPT 80321: Alcohol Biomarker Assay, One or Two Compounds

    CPT-80322-ALCOHOL-BIOMARKER-PANEL-MULTI-ANALYTE

    CPT 80322: Alcohol Biomarker Panel, Three or More Compounds

    CPT-80323-ALKALOID-DRUG-LEVEL-ANALYSIS

    CPT 80323: Alkaloid Drug Identification and Quantitation

    CPT-80324-AMPHETAMINE-DRUG-TESTING-LAB-ASSAY

    CPT 80324: Amphetamine Detection and Quantification

    CPT-80325-AMPHETAMINES-DETECTION-AND-QUANTIFICATION

    CPT 80325: Detection of Three or Four Amphetamines

    CPT-80326-AMPHETAMINES-PANEL-5-OR-MORE

    CPT 80326: Detection/Quantification of Five or More Amphetamines

    CPT-80334-SEROTONERGIC-ANTIDEPRESSANT-PANEL

    CPT 80334: Detection of Six or More Serotonergic Antidepressants

    CPT-80335-TRICYCLIC-ANTIDEPRESSANT-ASSAY

    CPT 80335: Tricyclic and Cyclical Antidepressant Assay

    CPT-80344-MULTI-ANTIPSYCHOTIC-PANEL-SEVEN-PLUS-DRUGS

    CPT 80344: Multiplex Antipsychotic Drug Detection (7+ agents)

    Showing 1–10 of 24

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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