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    v1.0.28
    OpenPayerBilling CodesDefinitive Drug Testing ProceduresCPT cpt-80371-synthetic-stimulant-bath-salts-detection
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    CPT 80371: Detection of Synthetic Stimulants (Bath Salts) in Specimen

    CPT code 80371 describes a laboratory test that measures or detects the presence of synthetic stimulants (commonly called “bath salts”) in a patient specimen; this represents a toxicology/drug-screen analytic service performed on biological specimens to identify recreational synthetic stimulant compounds. Service type: toxicology/drug screen – laboratory analytic. Typical site of service: clinical laboratory or hospital laboratory where patient specimens (blood, urine, or other approved samples) are collected and analyzed for synthetic cathinones and related stimulants.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Clinical & Coding Specifications

    Clinical Context

    A patient presents to the emergency department or outpatient clinic with acute agitation, altered mental status, tachycardia, hypertension, diaphoresis, or suspected intoxication after reported recreational drug use. The treating clinician orders a toxicology panel targeted to synthetic stimulants (commonly called "bath salts") to identify cathinone derivatives and related synthetic stimulants in blood or urine. A phlebotomy or urine collection is performed, the specimen is sent to the clinical laboratory, and the laboratory analyst performs qualitative or quantitative testing using immunoassay screening followed by confirmatory testing (e.g., GC-MS or LC-MS/MS) as needed. Results are reported to the ordering clinician to guide acute management, disposition, and any required public health or forensic documentation. Typical sites of service include hospital inpatient and emergency departments, hospital outpatient laboratories, and independent clinical toxicology laboratories.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80371Drug screen, qualitative; multiple drug classes (e.g., synthetic stimulants / "bath salts")Primary code for laboratory detection of synthetic stimulants in specimen; used for reporting the analytic test performed.
    80307Drug test(s), presumptive, any number of drug classes; each procedure to detect presence of specific drug classes using immunoassayOften used for initial rapid immunoassay screening prior to confirmatory testing for synthetic stimulants.
    80305Drug test(s), presumptive, any number of drug classes; certain standard panelsMay be billed for limited-panel screening when synthetic stimulant immunoassay is part of a broader screen.
    80320Confirmation, quantitative, drug(s) of abuse; individual drug class by GC-MS or LC-MS/MSUsed when a positive screening result for synthetic stimulants requires confirmatory quantitative testing for definitive identification.
    82570Assay of ethanol or blood alcohol concentrationCommon parallel test in intoxication workup to evaluate alcohol co-ingestion in acute presentations.
    80316Drug test, quantitative; multiple drug classes by definitive methodsAlternative code for multiplex confirmatory toxicology panels that include synthetic stimulants measured quantitatively.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    208100000XPhysical Medicine & Rehabilitation PhysicianPhysical medicine and rehabilitation, also referred to as rehabilitation medicine, is the medical specialty concerned with diagnosing, evaluating, and…
    208M00000XHospitalist PhysicianHospitalists are physicians whose primary professional focus is the general medical care of hospitalized patients. Their activities include patient ca…
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    261QR0400XRehabilitation Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    171100000XAcupuncturistAn acupuncturist is a person who performs ancient therapy for alleviation of pain, anesthesia and treatment of some diseases. Acupuncturists use long,…
    332S00000XHearing Aid EquipmentThe manufacture and/or sale of electronic hearing aids, their component parts, and related products and services on a national basis.

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    CPT-80320-ALCOHOL-DETECTION-IN-SPECIMEN

    CPT 80320: Alcohol Detection and Quantification

    CPT-80321-ALCOHOL-BIOMARKER-ASSAY

    CPT 80321: Alcohol Biomarker Assay, One or Two Compounds

    CPT-80322-ALCOHOL-BIOMARKER-PANEL-MULTI-ANALYTE

    CPT 80322: Alcohol Biomarker Panel, Three or More Compounds

    CPT-80323-ALKALOID-DRUG-LEVEL-ANALYSIS

    CPT 80323: Alkaloid Drug Identification and Quantitation

    CPT-80324-AMPHETAMINE-DRUG-TESTING-LAB-ASSAY

    CPT 80324: Amphetamine Detection and Quantification

    CPT-80325-AMPHETAMINES-DETECTION-AND-QUANTIFICATION

    CPT 80325: Detection of Three or Four Amphetamines

    CPT-80326-AMPHETAMINES-PANEL-5-OR-MORE

    CPT 80326: Detection/Quantification of Five or More Amphetamines

    CPT-80334-SEROTONERGIC-ANTIDEPRESSANT-PANEL

    CPT 80334: Detection of Six or More Serotonergic Antidepressants

    CPT-80335-TRICYCLIC-ANTIDEPRESSANT-ASSAY

    CPT 80335: Tricyclic and Cyclical Antidepressant Assay

    CPT-80344-MULTI-ANTIPSYCHOTIC-PANEL-SEVEN-PLUS-DRUGS

    CPT 80344: Multiplex Antipsychotic Drug Detection (7+ agents)

    Showing 1–10 of 24

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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