CPT code 80324 represents a laboratory toxicology assay that measures or detects one or two amphetamines in a patient specimen. Nationally, this code is used in clinical toxicology, substance use monitoring, forensic screening, and therapeutic oversight where identification of stimulant exposure is clinically relevant. Accurate coding of 80324 affects clinical documentation, laboratory workflows, and payer coverage determinations for drug testing services.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the clinical context for amphetamine testing, typical sites of service, and payer coverage considerations. The publication outlines common billing modifiers and highlights what benchmarks and policy update areas to review for this type of laboratory service. It also describes typical clinical use cases such as substance use disorder monitoring, workplace testing, and clinical toxicology evaluations.

This resource provides clinicians, laboratory managers, and billing professionals with clear, actionable information about the purpose of CPT code 80324, the clinical settings where it is performed, and the payer landscape relevant to national billing and coverage practices.