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CPT 54250: Nocturnal Penile Tumescence Monitoring

CPT code 54250 denotes nocturnal penile tumescence (NPT), an overnight, electronic monitoring procedure that records the frequency, rigidity, and circumferential changes of erections during REM sleep to help assess erectile dysfunction. Nationally, this code is relevant for clinicians and payers evaluating diagnostic pathways for erectile dysfunction and for facilities that provide overnight sleep-based urologic testing. Key payers in scope include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare.

Readers will find a concise overview of the clinical purpose of NPT monitoring, benchmarks for use and typical sites of service (sleep laboratories or outpatient diagnostic facilities), and discussion of payer coverage considerations and common modifier usage where available. The publication summarizes clinical context for when NPT is used versus alternative evaluations, and it outlines policy-related topics that affect coverage and coding practice for this diagnostic service. Data not available in the input is noted where applicable.

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Billing Code Overview

CPT code 54250 describes nocturnal penile tumescence (NPT) monitoring, an electronic test that measures the frequency, rigidity, and circumferential changes of erections during rapid eye movement (REM) sleep. The procedure helps determine the extent and possible physiologic contribution to a patient’s erectile dysfunction.

Service type: Diagnostic sleep-related urologic monitoring

Typical site of service: Sleep laboratory or outpatient diagnostic facility (overnight monitoring during sleep)

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CPT 54250: Nocturnal Penile Tumescence Monitoring

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Get alerted when payer policies referencing 54250 are released or updated.

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Billing Code Overview

Service type: Diagnostic sleep-related urologic monitoring

Typical site of service: Sleep laboratory or outpatient diagnostic facility (overnight monitoring during sleep)

Clinical & Coding Specifications

Clinical Context

A 48-year-old male presents to a urology clinic with a 6-month history of erectile dysfunction (ED) characterized by difficulty achieving and maintaining erections sufficient for sexual intercourse. The patient reports nocturnal and morning erections have decreased. The urologist orders nocturnal penile tumescence testing to distinguish organic from psychogenic causes. The procedure is scheduled as an overnight home-based or sleep-laboratory monitored test. A trained technician instructs the patient on device placement (rigidity rings, sensors) prior to sleep; the device electronically records frequency, duration, rigidity, and circumferential changes during REM cycles. The recording is retrieved the next day, interpreted by the urologist, and documented in the clinic note. Results help determine whether the ED is primarily physiologic (reduced nocturnal erections) or psychogenic (normal nocturnal erections), guiding further evaluation and management.

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when billing only the physician interpretation/report of the NPT separate from technical recording.
`TC`	Technical component	Use when billing only the equipment placement and data recording (typically by facility or technician).
`52`	Reduced service	Use when a shortened or partial NPT is performed due to patient intolerance or early termination.
`53`	Discontinued procedure	Use when the NPT is started but discontinued for patient safety or unforeseen circumstances.
`59`	Distinct procedural service	Not in provided list; Data not available in the input.
`76`	Repeat procedure by same physician	Not in provided list; Data not available in the input.
`77`	Repeat procedure by another physician	Not in provided list; Data not available in the input.
`78`	Unplanned return to the operating/procedure room by the same physician following initial procedure	Use if an unplanned repeat overnight study is required during the same encounter due to equipment failure (rare).
`79`	Unrelated procedure or service by the same physician during the postoperative period	Not in provided list; Data not available in the input.
`91`	Repeat clinical diagnostic laboratory test	Not applicable; Data not available in the input.

Taxonomy Code	Specialty	Notes
2084P0800X	Urology	Urologists commonly interpret NPT testing results and manage ED.
261QP0200X	Sleep Medicine	Sleep medicine physicians or technologists may supervise in-lab overnight monitoring.
363L00000X	Clinical Neurophysiology	Technologists skilled in physiologic monitoring may perform device setup and data collection.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`N52.9`	Male erectile dysfunction, unspecified	Most common indication for NPT testing to differentiate organic versus psychogenic ED.
`F52.2`	Male erectile disorder	Psychiatric/psychogenic causes of erectile dysfunction; NPT helps identify preserved nocturnal erections suggesting psychogenic etiology.
`E11.9`	Type 2 diabetes mellitus without complications	Diabetes is a common organic contributor to ED; NPT assists in assessing physiologic erectile function.
`I10`	Essential (primary) hypertension	Vascular disease from hypertension can cause organic ED; NPT evaluates nocturnal rigidity.
`G47.9`	Sleep disorder, unspecified	Sleep disturbances can alter REM cycles and affect NPT interpretation; may prompt combined sleep study.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`54250`	Nocturnal penile tumescence (NPT), electronically monitoring frequency, rigidity, and/or circumferential changes of erections during REM sleep	Primary code for the overnight diagnostic monitoring procedure.
`90911`	Biofeedback training, any modality, per 15 minutes; therapist time	May be used in pelvic floor rehabilitation programs for sexual dysfunction adjunctive to diagnostic evaluation.
`95810`	Polysomnography; sleep staging with continuous airway pressure titration, attended by technologist	Sleep laboratory-based NPT may be performed in conjunction with broader polysomnography when sleep disorder comorbidity is suspected.
`99000`	Handling and/or conveyance of specimen for transfer from physician to laboratory	Not typically used; Data not available in the input.
`99070`	Supplies and materials (e.g., bandages, gauze, instruments) provided by the physician over and above those usually included with the office visit or procedure	Use for disposable sensors or recording supplies when billable separately.

CPT 54200: Penile Injection for Peyronie Disease

CPT-54205-PENILE-PLAQUE-EXPOSURE-AND-INJECTION-FOR-PEYRONIE-DISEASE

CPT 54205: Penile Plaque Exposure and Injection for Peyronie Disease

CPT-54220-IRRIGATION-OF-CORPORA-CAVERNOSA-PRIAPISM

CPT 54220: Irrigation of Corpora Cavernosa for Priapism

CPT-54230-CAVERNOSOGRAPHY-VENOUS-LEAKAGE-EVALUATION

CPT 54230: Cavernosography to Evaluate Venous Leakage

CPT-54231-DYNAMIC-CAVERNOSOMETRY-WITH-PHARMACOLOGIC-INJECTION

CPT 54231: Dynamic Cavernosometry with Pharmacologic Intracavernosal Injection

CPT-54235-INTRACAVERNOSAL-PHARMACOLOGIC-INJECTION-FOR-ED

CPT 54235: Intracavernosal Pharmacologic Injection for Erectile Dysfunction

CPT-54240-PENILE-PLETHYSMOGRAPHY-ERECTILE-DYSFUNCTION-ASSESSMENT

CPT 54240: Penile Plethysmography for Erectile Dysfunction Assessment

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

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Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when billing only the physician interpretation/report of the NPT separate from technical recording.
`TC`	Technical component	Use when billing only the equipment placement and data recording (typically by facility or technician).
`52`	Reduced service	Use when a shortened or partial NPT is performed due to patient intolerance or early termination.
`53`	Discontinued procedure	Use when the NPT is started but discontinued for patient safety or unforeseen circumstances.
`59`	Distinct procedural service	Not in provided list; Data not available in the input.
`76`	Repeat procedure by same physician	Not in provided list; Data not available in the input.
`77`	Repeat procedure by another physician	Not in provided list; Data not available in the input.
`78`	Unplanned return to the operating/procedure room by the same physician following initial procedure	Use if an unplanned repeat overnight study is required during the same encounter due to equipment failure (rare).
`79`	Unrelated procedure or service by the same physician during the postoperative period	Not in provided list; Data not available in the input.
`91`	Repeat clinical diagnostic laboratory test	Not applicable; Data not available in the input.

Taxonomy Code	Specialty	Notes
2084P0800X	Urology	Urologists commonly interpret NPT testing results and manage ED.
261QP0200X	Sleep Medicine	Sleep medicine physicians or technologists may supervise in-lab overnight monitoring.
363L00000X	Clinical Neurophysiology	Technologists skilled in physiologic monitoring may perform device setup and data collection.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`N52.9`	Male erectile dysfunction, unspecified	Most common indication for NPT testing to differentiate organic versus psychogenic ED.
`F52.2`	Male erectile disorder	Psychiatric/psychogenic causes of erectile dysfunction; NPT helps identify preserved nocturnal erections suggesting psychogenic etiology.
`E11.9`	Type 2 diabetes mellitus without complications	Diabetes is a common organic contributor to ED; NPT assists in assessing physiologic erectile function.
`I10`	Essential (primary) hypertension	Vascular disease from hypertension can cause organic ED; NPT evaluates nocturnal rigidity.
`G47.9`	Sleep disorder, unspecified	Sleep disturbances can alter REM cycles and affect NPT interpretation; may prompt combined sleep study.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`54250`	Nocturnal penile tumescence (NPT), electronically monitoring frequency, rigidity, and/or circumferential changes of erections during REM sleep	Primary code for the overnight diagnostic monitoring procedure.
`90911`	Biofeedback training, any modality, per 15 minutes; therapist time	May be used in pelvic floor rehabilitation programs for sexual dysfunction adjunctive to diagnostic evaluation.
`95810`	Polysomnography; sleep staging with continuous airway pressure titration, attended by technologist	Sleep laboratory-based NPT may be performed in conjunction with broader polysomnography when sleep disorder comorbidity is suspected.
`99000`	Handling and/or conveyance of specimen for transfer from physician to laboratory	Not typically used; Data not available in the input.
`99070`	Supplies and materials (e.g., bandages, gauze, instruments) provided by the physician over and above those usually included with the office visit or procedure	Use for disposable sensors or recording supplies when billable separately.

CPT 54200: Penile Injection for Peyronie Disease

CPT-54205-PENILE-PLAQUE-EXPOSURE-AND-INJECTION-FOR-PEYRONIE-DISEASE

CPT 54205: Penile Plaque Exposure and Injection for Peyronie Disease

CPT-54220-IRRIGATION-OF-CORPORA-CAVERNOSA-PRIAPISM

CPT 54220: Irrigation of Corpora Cavernosa for Priapism

CPT-54230-CAVERNOSOGRAPHY-VENOUS-LEAKAGE-EVALUATION

CPT 54230: Cavernosography to Evaluate Venous Leakage

CPT-54231-DYNAMIC-CAVERNOSOMETRY-WITH-PHARMACOLOGIC-INJECTION

CPT 54231: Dynamic Cavernosometry with Pharmacologic Intracavernosal Injection

CPT-54235-INTRACAVERNOSAL-PHARMACOLOGIC-INJECTION-FOR-ED

CPT 54235: Intracavernosal Pharmacologic Injection for Erectile Dysfunction

CPT-54240-PENILE-PLETHYSMOGRAPHY-ERECTILE-DYSFUNCTION-ASSESSMENT

CPT 54240: Penile Plethysmography for Erectile Dysfunction Assessment

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

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CPT 54250: Nocturnal Penile Tumescence Monitoring

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Billing Code Overview

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CPT 54250: Nocturnal Penile Tumescence Monitoring

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Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

CPT 54250: Nocturnal Penile Tumescence Monitoring

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Billing Code Overview

CPT 54250: Nocturnal Penile Tumescence Monitoring

Sign up for cpt 54250 policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What does CPT 54250 represent and where is this service typically provided?

Which CPT modifiers are indicated for splitting professional and technical components of NPT billing?

How should reduced, discontinued, or unplanned repeat NPT procedures be coded?

Which specialties and taxonomy codes are commonly associated with performing or interpreting NPT?

What ICD-10 diagnoses commonly justify or relate to ordering an NPT study?

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What does CPT 54250 represent and where is this service typically provided?

Which CPT modifiers are indicated for splitting professional and technical components of NPT billing?

How should reduced, discontinued, or unplanned repeat NPT procedures be coded?

Which specialties and taxonomy codes are commonly associated with performing or interpreting NPT?

What ICD-10 diagnoses commonly justify or relate to ordering an NPT study?

References