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    OpenPayerBilling CodesIntroduction Procedures on the PenisCPT cpt-54235-intracavernosal-pharmacologic-injection-for-ed
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    CPT 54235: Intracavernosal Injection for Erectile Dysfunction

    Medicare pays $98 on average nationally for this procedure.

    CPT code 54235 describes intracavernosal injection of pharmacologic agents (for example, papaverine, phentolamine, or prostaglandin E1) into the corpora cavernosa to evaluate or treat erectile dysfunction; this is an invasive, clinician‑administered pharmacologic injection procedure typically performed in an outpatient clinic, urology office, or ambulatory surgical setting for diagnostic and therapeutic management of erectile dysfunction.

    For related coverage guidance, see recent payer policy updates: Lymphedema - Surgical Treatment - Medical Policy, Breast Reduction (Mammoplasty) Surgery, Mastectomy Treatment, Breast Reconstruction and Mastectomy Hospital Stays Mandates.

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old male with a history of diabetes mellitus and coronary artery disease presents to the outpatient urology clinic with a 12-month history of persistent erectile dysfunction refractory to oral phosphodiesterase-5 inhibitors. After clinical evaluation, counseling on risks and benefits, and informed consent, the urologist performs intracavernosal injection therapy in clinic. The provider prepares a pharmacologic agent such as prostaglandin E1 (alprostadil) or a combination agent, cleans the penile shaft with antiseptic, identifies the lateral corpora cavernosa, and injects a measured dose into one corpus cavernosum. The patient is observed for immediate complications (pain, priapism, hematoma) for 15–30 minutes in the clinic, provided post-procedure instructions, and scheduled for follow-up to assess efficacy and possible repeat therapy or alternative interventions.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    54235Injection of pharmacologic agent into corporal body of penisPrimary procedure: intracavernosal pharmacologic injection for erectile dysfunction.
    54240Intra-corporal injection for diagnostic erection testDiagnostic injection performed when assessing vascular causes of ED before therapeutic injections.
    54250Surgical correction of penile curvature (eg, Peyronie disease)Performed when structural causes of ED are identified and surgical correction is required instead of injection therapy.
    54400Implantation of penile prosthesis, inflatable or semi-rigidDefinitive surgical treatment for refractory erectile dysfunction when injections fail or are contraindicated.
    53855Removal of penile prosthesisMay be performed if a prior penile implant causes complications and subsequent management includes injections or alternative therapy.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2084P0800X
    208800000X
    207R00000X
    322D00000X
    2251C2600X
    261QM1102X
    163WX0601X
    363LW0102X

    Related Payer Policy Updates

    Specialty: Plastic/Reconstructive Surgery1 / 2

    10 rows

    PolicyPayerEffective Date
    Lymphedema - Surgical Treatment - Medical PolicyHealth-New-England2027-02-01
    Breast Reduction (Mammoplasty) SurgeryKaiser Permanente2027-02-01
    Mastectomy Treatment, Breast Reconstruction and Mastectomy Hospital Stays MandatesBlue Cross Blue Shield - Rhode Island2027-01-01
    Lipodystrophy Syndrome - HIV Associated - Medical PolicyHealth-New-England2026-12-01
    Abdominal Panniculectomy and Excision of Excessive Skin and Subcutaneous Tissue - Medical PolicyHealth-New-England2026-12-01
    Reduction MammaplastyBlue Cross Blue Shield - North Dakota2026-11-01
    Cosmetic and Reconstructive ProceduresAmbetter Georgia2026-11-01
    Surgical Treatment of Lipedema and Lymphedemahusky_health2026-11-01
    Rhinoplasty Medical Necessity and Site of ServicePremera Bluecross2026-10-14
    Reconstructive Breast Surgery/Mastopexy, and Management of Breast ImplantsBlue Cross Blue Shield - North Dakota2026-10-01

    Related Codes

    CPT-54200-PENILE-INJECTION-FOR-PEYRONIE-DISEASE

    CPT 54200: Intralesional Injection for Peyronie Disease

    CPT-54205-PENILE-PLAQUE-EXPOSURE-AND-INJECTION-FOR-PEYRONIE-DISEASE

    CPT 54205: Penile Plaque Exposure and Injection for Peyronie Disease

    CPT-54220-IRRIGATION-OF-CORPORA-CAVERNOSA-PRIAPISM

    CPT 54220: Irrigation of Corpora Cavernosa for Priapism

    CPT-54230-CAVERNOSOGRAPHY-VENOUS-LEAKAGE-EVALUATION

    CPT 54230: Cavernosography for Venous Leakage Evaluation

    CPT-54231-DYNAMIC-CAVERNOSOMETRY-WITH-PHARMACOLOGIC-INJECTION

    CPT 54231: Dynamic Cavernosometry with Intracavernosal Injection

    CPT-54240-PENILE-PLETHYSMOGRAPHY-ERECTILE-DYSFUNCTION-ASSESSMENT

    CPT 54240: Penile Plethysmography for Erectile Dysfunction Assessment

    CPT-54250-NOCTURNAL-PENILE-TUMESCENCE-NPT-MONITORING

    CPT 54250: Nocturnal Penile Tumescence (NPT) Testing

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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