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    OpenPayerBilling CodesIntroduction Procedures on the PenisCPT cpt-54205-penile-plaque-exposure-and-injection-for-peyronie-disease
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    CPT 54205: Penile Plaque Exposure and Injection for Peyronie Disease

    Medicare pays $498 on average nationally for this procedure.

    CPT code 54205 describes a surgical procedure for Peyronie disease in which the provider makes an incision in the external penile skin, exposes the penile plaque, and injects medication directly into the plaque; this is a surgical plaque exposure with intralesional injection typically performed as an outpatient urologic procedure in an ambulatory surgery center or hospital outpatient setting for treatment of penile curvature due to localized fibrous plaque.

    For related coverage guidance, see recent payer policy updates: Lymphedema - Surgical Treatment - Medical Policy, Breast Reduction (Mammoplasty) Surgery, Mastectomy Treatment, Breast Reconstruction and Mastectomy Hospital Stays Mandates.

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    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old male presents to a urology clinic with a 6-month history of progressive penile curvature and painful erections consistent with Peyronie disease. Conservative measures and oral therapy provided inadequate symptomatic relief. After evaluation including penile duplex ultrasound to localize and measure plaque and curvature, the urologist schedules an in-office or ambulatory surgical center procedure to directly expose the dorsal penile plaque and administer an intralesional medication (for example, collagenase clostridium histolyticum or other injectable agents) into the plaque. The workflow includes pre-procedure consent, surgical site marking, local or regional anesthesia, an external penile skin incision to expose the plaque, targeted injection into the plaque, hemostasis, and layered closure of the incision. Post-procedure instructions address pain control, wound care, activity restrictions, and follow-up to assess curvature improvement and wound healing. Typical monitoring may include assessment for hematoma, infection, penile numbness, or corporal injury, with return precautions and scheduled follow-up at 1–4 weeks and at 3 months for functional outcome assessment.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    54205Injection and incision to expose penile plaque for Peyronie disease (described procedure)Primary procedure for direct exposure of plaque and intralesional injection to correct Peyronie curvature.
    54200Injection into penis, intracavernosal or subcutaneous (non-plaquecentric)May be used for diagnostic or therapeutic intracavernosal injections distinct from plaque exposure; sometimes performed in evaluation of erectile function prior to plaque-directed therapy.
    54210Repair of penis, extensive surgical procedures including corporoplasty for correction of curvaturePerformed for more extensive surgical correction when plaque excision and grafting or plication/corporoplasty are required beyond simple plaque injection.
    54050Circumcision, device or surgical (simple)May be performed concurrently if exposure or access to dorsal plaque requires distal penile skin management, or for separate indications.
    51702Irrigation of bladder, simpleData not directly related; included here as not applicable.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2084H0002X
    2080P0204X
    315P00000X
    103TC1900X
    3747P1801X
    261QP2400X
    207RI0011X
    2255R0406X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    E29.0Testicular hyperfunction
    E29.1Testicular hypofunction
    E29.9Testicular dysfunction, unspecified
    F45.41Pain disorder exclusively related to psychological factors
    F45.9Somatoform disorder, unspecified
    I83.813Varicose veins of bilateral lower extremities with pain
    I85.01Esophageal varices with bleeding
    I87.2Venous insufficiency (chronic) (peripheral)
    K59.9Functional intestinal disorder, unspecified
    M54.2Cervicalgia

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Plastic/Reconstructive Surgery1 / 2

    10 rows

    PolicyPayerEffective Date
    Lymphedema - Surgical Treatment - Medical PolicyHealth-New-England2027-02-01
    Breast Reduction (Mammoplasty) SurgeryKaiser Permanente2027-02-01
    Mastectomy Treatment, Breast Reconstruction and Mastectomy Hospital Stays MandatesBlue Cross Blue Shield - Rhode Island2027-01-01
    Lipodystrophy Syndrome - HIV Associated - Medical PolicyHealth-New-England2026-12-01
    Abdominal Panniculectomy and Excision of Excessive Skin and Subcutaneous Tissue - Medical PolicyHealth-New-England2026-12-01
    Reduction MammaplastyBlue Cross Blue Shield - North Dakota2026-11-01
    Cosmetic and Reconstructive ProceduresAmbetter Georgia2026-11-01
    Surgical Treatment of Lipedema and Lymphedemahusky_health2026-11-01
    Rhinoplasty Medical Necessity and Site of ServicePremera Bluecross2026-10-14
    Reconstructive Breast Surgery/Mastopexy, and Management of Breast ImplantsBlue Cross Blue Shield - North Dakota2026-10-01

    Related Codes

    CPT-54200-PENILE-INJECTION-FOR-PEYRONIE-DISEASE

    CPT 54200: Intralesional Injection for Peyronie Disease

    CPT-54220-IRRIGATION-OF-CORPORA-CAVERNOSA-PRIAPISM

    CPT 54220: Irrigation of Corpora Cavernosa for Priapism

    CPT-54230-CAVERNOSOGRAPHY-VENOUS-LEAKAGE-EVALUATION

    CPT 54230: Cavernosography for Venous Leakage Evaluation

    CPT-54231-DYNAMIC-CAVERNOSOMETRY-WITH-PHARMACOLOGIC-INJECTION

    CPT 54231: Dynamic Cavernosometry with Intracavernosal Injection

    CPT-54235-INTRACAVERNOSAL-PHARMACOLOGIC-INJECTION-FOR-ED

    CPT 54235: Intracavernosal Injection for Erectile Dysfunction

    CPT-54240-PENILE-PLETHYSMOGRAPHY-ERECTILE-DYSFUNCTION-ASSESSMENT

    CPT 54240: Penile Plethysmography for Erectile Dysfunction Assessment

    CPT-54250-NOCTURNAL-PENILE-TUMESCENCE-NPT-MONITORING

    CPT 54250: Nocturnal Penile Tumescence (NPT) Testing

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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