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    v1.0.30
    OpenPayerBilling CodesIntroduction Procedures on the PenisCPT cpt-54200-penile-injection-for-peyronie-disease
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    CPT 54200: Intralesional Injection for Peyronie Disease

    Medicare pays $125 on average nationally for this procedure.

    CPT code 54200 describes an intralesional injection of medication into the external penis to treat Peyronie disease; the service is a minimally invasive therapeutic procedure typically performed in an outpatient urology clinic or office procedure room and is intended to reduce plaque-related curvature of the erect penis.

    For related coverage guidance, see recent payer policy updates: Lymphedema - Surgical Treatment - Medical Policy, Breast Reduction (Mammoplasty) Surgery, Mastectomy Treatment, Breast Reconstruction and Mastectomy Hospital Stays Mandates.

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    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old man with a 1-year history of progressive penile curvature and painful erections presents to a urology clinic. He reports difficulty with sexual intercourse and localized penile plaque on exam consistent with Peyronie disease. Prior conservative management including oral therapies and observation provided inadequate symptom relief. After shared decision-making, the urologist schedules an in-office procedure to deliver intralesional medication into the tunica albuginea of the penis to reduce curvature and improve sexual function.

    The clinical workflow includes pre-procedure informed consent, focused genitourinary history and physical exam, measurement and photography of curvature in the erect state (or induced pharmacologic erection), marking the injection site, local anesthesia, sterile technique, and intralesional injection of a collagenase or other approved agent directed into the plaque. The provider documents indication, laterality (if applicable), number of injections, medication and dose, anesthesia, patient tolerance, and post-procedure instructions. Typical follow-up visits assess curvature improvement, adverse events, and need for repeat injections or adjunctive modeling therapies.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    54100Repair of penis, simple; for primary closure or tuning proceduresPerformed when surgical correction of penile curvature is required after or instead of intralesional therapy.
    54342Penile modeling procedure following intralesional injection (stretching/manipulation)Often performed in conjunction with intralesional injections as part of a treatment protocol to improve outcomes.
    99070Supplies and materials provided by the physician over and above those usually included with the office visit or other services (eg, surgical trays, supplies)Billed when additional supplies or special medication preparation are needed for the injection procedure.
    99213Office or other outpatient visit for the evaluation and management of an established patient, low to moderate complexityCommonly billed on the day of or around the procedure for pre- or post-procedure evaluation when distinct from the injection service.
    J0775Injection, collagenase clostridium histolyticum, 0.01 mgDrug HCPCS code used to report the specific intralesional medication when administered; billed separately from the procedure in some payor systems.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207K00000X
    207R00000X
    208D00000X
    251F00000X
    1223P0300X
    2086S0120X
    2471B0102X
    320600000X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    E03.9Hypothyroidism, unspecified
    E29.1Testicular hypofunction
    E29.9Testicular dysfunction, unspecified
    E66.9Obesity, unspecified
    F32.9Major depressive disorder, single episode, unspecified
    F41.9Anxiety disorder, unspecified
    F52.21Male erectile disorder
    F52.22Female sexual arousal disorder
    F52.9Unspecified sexual dysfunction not due to a substance or known physiological condition
    I10Essential (primary) hypertension

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Plastic/Reconstructive Surgery1 / 2

    10 rows

    PolicyPayerEffective Date
    Lymphedema - Surgical Treatment - Medical PolicyHealth-New-England2027-02-01
    Breast Reduction (Mammoplasty) SurgeryKaiser Permanente2027-02-01
    Mastectomy Treatment, Breast Reconstruction and Mastectomy Hospital Stays MandatesBlue Cross Blue Shield - Rhode Island2027-01-01
    Lipodystrophy Syndrome - HIV Associated - Medical PolicyHealth-New-England2026-12-01
    Abdominal Panniculectomy and Excision of Excessive Skin and Subcutaneous Tissue - Medical PolicyHealth-New-England2026-12-01
    Reduction MammaplastyBlue Cross Blue Shield - North Dakota2026-11-01
    Cosmetic and Reconstructive ProceduresAmbetter Georgia2026-11-01
    Surgical Treatment of Lipedema and Lymphedemahusky_health2026-11-01
    Rhinoplasty Medical Necessity and Site of ServicePremera Bluecross2026-10-14
    Reconstructive Breast Surgery/Mastopexy, and Management of Breast ImplantsBlue Cross Blue Shield - North Dakota2026-10-01

    Related Codes

    CPT-54205-PENILE-PLAQUE-EXPOSURE-AND-INJECTION-FOR-PEYRONIE-DISEASE

    CPT 54205: Penile Plaque Exposure and Injection for Peyronie Disease

    CPT-54220-IRRIGATION-OF-CORPORA-CAVERNOSA-PRIAPISM

    CPT 54220: Irrigation of Corpora Cavernosa for Priapism

    CPT-54230-CAVERNOSOGRAPHY-VENOUS-LEAKAGE-EVALUATION

    CPT 54230: Cavernosography for Venous Leakage Evaluation

    CPT-54231-DYNAMIC-CAVERNOSOMETRY-WITH-PHARMACOLOGIC-INJECTION

    CPT 54231: Dynamic Cavernosometry with Intracavernosal Injection

    CPT-54235-INTRACAVERNOSAL-PHARMACOLOGIC-INJECTION-FOR-ED

    CPT 54235: Intracavernosal Injection for Erectile Dysfunction

    CPT-54240-PENILE-PLETHYSMOGRAPHY-ERECTILE-DYSFUNCTION-ASSESSMENT

    CPT 54240: Penile Plethysmography for Erectile Dysfunction Assessment

    CPT-54250-NOCTURNAL-PENILE-TUMESCENCE-NPT-MONITORING

    CPT 54250: Nocturnal Penile Tumescence (NPT) Testing

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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