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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the KidneyCPT cpt-50250-kidney-cryoablation-cryosurgery
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    CPT 50250: Kidney Cryoablation/Cryosurgery

    Medicare pays $1107 on average nationally for this procedure.

    CPT code 50250 describes cryoablation or cryosurgery of a renal lesion, a procedure using extreme cold delivered via a probe containing liquid nitrogen inserted into the kidney to destroy a mass, tumor, or cancer cells; this is a percutaneous or open surgical ablative procedure typically performed in an operating room or interventional radiology suite with monitored anesthesia care or general anesthesia for image-guided targeting and tissue destruction.

    For related coverage guidance, see recent payer policy updates: Surgical Procedures, Outpatient Surgical Procedures - Site of Service, Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old male with a solitary 2.8 cm enhancing renal mass identified on abdominal CT is evaluated by a urologist and interventional radiologist. The patient has chronic kidney disease stage 3 and cardiac comorbidity that make partial nephrectomy higher risk. After multidisciplinary discussion the team elects percutaneous cryoablation of the renal tumor under CT or ultrasound guidance with conscious sedation or general anesthesia. Pre-procedure workflow includes informed consent, review of cross-sectional imaging to confirm lesion size and location, laboratory checks (including coagulation panel), and placement of monitoring and IV access. In the procedure suite, the interventional radiologist places cryoprobes percutaneously into the tumor using image guidance, performs freeze–thaw cycles to achieve an adequate ice-ball margin around the lesion, monitors adjacent structures with hydrodissection if needed, and obtains immediate post-ablation imaging to document extent of ablation and rule out complications. Post-procedure, the patient is observed in recovery, monitored for hematuria or bleeding, receives analgesia as needed, and is discharged with follow-up imaging scheduled to assess treatment response.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    10021Fine needle aspiration without imaging guidanceMay be performed prior to ablation for tissue diagnosis if percutaneous biopsy is indicated
    10022Fine needle aspiration with imaging guidanceImage-guided biopsy to obtain cytology prior to or during the same session as ablation
    76937Ultrasound guidance for percutaneous proceduresUsed during probe placement for real-time localization of renal lesions
    77012CT guidance for needle placement (CT fluoroscopy)CT-guided probe placement and monitoring during cryoablation
    32555Tube thoracostomy, includes drainageData not available in the input.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2084P0800X
    208800000X
    207K00000X
    364SM0705X
    2084P0015X
    103TP2701X
    1835E0208X
    207UN0903X

    Related Payer Policy Updates

    Specialty: General Surgery1 / 2

    10 rows

    PolicyPayerEffective Date
    Surgical ProceduresUnitedHealthcare2026-09-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01

    Related Codes

    CPT-50200-PERCUTANEOUS-RENAL-ASPIRATION-DIAGNOSTIC-BIOPSY

    CPT 50200: Percutaneous Renal Needle Biopsy

    CPT-50205-PERCUTANEOUS-KIDNEY-BIOPSY-SAMPLING

    CPT 50205: Kidney Needle Collection for Diagnostic Biopsy

    CPT-50220-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50220: Partial or Complete Nephrectomy, Kidney Removal

    CPT-50225-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50225: Nephrectomy (Kidney Removal)

    CPT-50230-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50230: Nephrectomy, Kidney Removal

    CPT-50234-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50234: Nephrectomy, Kidney Removal

    CPT-50236-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50236: Nephrectomy (Kidney Removal)

    CPT-50240-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50240: Nephrectomy, Kidney Removal

    CPT-50280-RENAL-CYST-EXCISION-OPEN-DEROOFING

    CPT 50280: Excision/Removal of Renal Surface Cyst(s)

    CPT-50290-EXCISION-KIDNEY-SURROUNDING-TISSUE-CYST

    CPT 50290: Excision of Perirenal Cyst

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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