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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the KidneyCPT cpt-50220-nephrectomy-kidney-removal
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    CPT 50220: Partial or Complete Nephrectomy, Kidney Removal

    Medicare pays $977 on average nationally for this procedure.

    CPT code 50220 describes a nephrectomy procedure for partial or complete surgical removal of a kidney and encompasses operative techniques used to excise renal tissue; this surgical service is typically performed by a urologist or transplant surgeon and is provided in an inpatient or hospital operating room setting as a major operative abdominal procedure.

    For related coverage guidance, see recent payer policy updates: Surgical Procedures, Outpatient Surgical Procedures - Site of Service, Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old male with a 3.5 cm enhancing mass in the right renal pole identified on contrast CT is scheduled for a partial nephrectomy to remove the tumor while preserving renal function. The patient has hypertension and stage 2 chronic kidney disease; preoperative evaluation includes labs, crossmatch, and anesthetic assessment. The procedure is performed in an operating room under general anesthesia by a urologist with an assistant; intraoperative steps include renal artery control, tumor excision with negative margins, renorrhaphy, and hemostasis. Typical perioperative workflow includes preoperative imaging review, informed consent, time-out, operative report documentation specifying laterality and technique (open, laparoscopic, or robotic-assisted), specimen submission to pathology, postoperative monitoring in PACU with pain control and urine output assessment, and discharge planning with follow-up for pathology results and renal function monitoring.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    50590Renal biopsy, percutaneous, transtubular or open, with imaging guidance if performedMay be performed preoperatively to obtain tissue diagnosis when imaging is indeterminate
    50948Laparoscopy, surgical; nephrectomy, partial or total, including partial ureterectomyLaparoscopic approach alternative to open nephrectomy; used when minimally invasive technique is chosen
    55866Laparoscopy, surgical; cryoablation of renal tumorAlternative minimally invasive ablative treatment for small renal masses in select patients
    88104Cytopathology, smears, or surgical pathology interpretation (example code for specimen pathology)Pathology interpretation for nephrectomy specimens to determine tumor type and margins
    99223Initial hospital care, typically 70 minutes or moreTypical code for initial inpatient evaluation and management related to major surgery like nephrectomy

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    208600000X
    207RH0000X
    1041C0700X
    207VM0101X
    207RM1200X
    171000000X
    124Q00000X

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    C64.1Malignant neoplasm of right kidney, except renal pelvis
    C64.2Malignant neoplasm of left kidney, except renal pelvis
    C64.9Malignant neoplasm of unspecified kidney, except renal pelvis
    C65.9Malignant neoplasm of unspecified renal pelvis
    C67.9Malignant neoplasm of bladder, unspecified
    D59.0Drug-induced autoimmune hemolytic anemia
    D61.9Aplastic anemia, unspecified
    D63.8Anemia in other chronic diseases classified elsewhere
    I12.0Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease
    I13.11Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: General Surgery1 / 2

    10 rows

    PolicyPayerEffective Date
    Surgical ProceduresUnitedHealthcare2026-09-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01

    Related Codes

    CPT-50200-PERCUTANEOUS-RENAL-ASPIRATION-DIAGNOSTIC-BIOPSY

    CPT 50200: Percutaneous Renal Needle Biopsy

    CPT-50205-PERCUTANEOUS-KIDNEY-BIOPSY-SAMPLING

    CPT 50205: Kidney Needle Collection for Diagnostic Biopsy

    CPT-50225-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50225: Nephrectomy (Kidney Removal)

    CPT-50230-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50230: Nephrectomy, Kidney Removal

    CPT-50234-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50234: Nephrectomy, Kidney Removal

    CPT-50236-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50236: Nephrectomy (Kidney Removal)

    CPT-50240-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50240: Nephrectomy, Kidney Removal

    CPT-50250-KIDNEY-CRYOABLATION-CRYOSURGERY

    CPT 50250: Kidney Cryoablation/Cryosurgery

    CPT-50280-RENAL-CYST-EXCISION-OPEN-DEROOFING

    CPT 50280: Excision/Removal of Renal Surface Cyst(s)

    CPT-50290-EXCISION-KIDNEY-SURROUNDING-TISSUE-CYST

    CPT 50290: Excision of Perirenal Cyst

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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