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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the KidneyCPT cpt-50225-nephrectomy-kidney-removal
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    CPT 50225: Nephrectomy (Kidney Removal)

    Medicare pays $1077 on average nationally for this procedure.

    CPT code 50225 describes a nephrectomy procedure involving removal of a kidney or part of a kidney; this surgical service is an operative urologic procedure typically performed in an inpatient hospital or ambulatory surgical center setting and involves excision of renal tissue for indications such as malignancy, severe trauma, or nonfunctional kidney disease.

    For related coverage guidance, see recent payer policy updates: Surgical Procedures, Outpatient Surgical Procedures - Site of Service, Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults.

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old male with a 3-month history of right-sided flank pain and hematuria is evaluated after imaging demonstrates a 4.5 cm enhancing mass in the right renal cortex suspicious for renal cell carcinoma. Past medical history includes hypertension and well-controlled type 2 diabetes. After multidisciplinary review, the patient is scheduled for an elective open right partial nephrectomy with regional lymph node assessment to remove the tumor and preserve renal function.

    Preoperative workflow includes history and physical, pre-op labs (CBC, BMP, coagulation), abdominal CT with contrast, anesthesiology evaluation, and informed consent documenting the indication and planned procedure. Intraoperative workflow includes general anesthesia, abdominal access, vascular control of the renal artery and vein, tumor excision with negative margins, renorrhaphy, hemostasis, possible ureteral stent placement if collecting system entered, and documentation of blood loss and any complications. Postoperative care includes monitoring in PACU, pain control, fluid management, assessment of urine output and renal function, pathology review of the specimen, and discharge planning with outpatient follow-up for wound care and oncology/genitourinary clinic review.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    50220Radical nephrectomy, including removal of tumor, kidney, and surrounding fat; may include regional lymphadenectomyAlternative extirpative procedure for larger or centrally located renal tumors; chosen instead of partial nephrectomy when oncologically indicated.
    50590Laparoscopy, surgical; nephrectomy or partial nephrectomy (partial or total)Minimally invasive approach option; laparoscopic nephrectomy may be performed instead of open 50225 depending on surgeon and case complexity.
    50948Ureteral stent placement (ureteral catheterization), intraoperativeMay be performed during partial nephrectomy if the collecting system is entered or to protect urine drainage.
    44970Insertion of intraperitoneal drain (surgical)Drains may be placed at the conclusion of the nephrectomy for postoperative fluid/bleeding management.
    99223Initial hospital care, typically 70 minutes or moreCommon hospital inpatient evaluation and management code for complex postoperative care following major surgery like nephrectomy.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2085P0229X
    207L00000X
    363LF0000X
    332BX2000X
    385HR2050X
    207ZP0007X
    2085U0001X
    163WC1400X

    Related Payer Policy Updates

    Specialty: General Surgery1 / 2

    10 rows

    PolicyPayerEffective Date
    Surgical ProceduresUnitedHealthcare2026-09-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01

    Related Codes

    CPT-50200-PERCUTANEOUS-RENAL-ASPIRATION-DIAGNOSTIC-BIOPSY

    CPT 50200: Percutaneous Renal Needle Biopsy

    CPT-50205-PERCUTANEOUS-KIDNEY-BIOPSY-SAMPLING

    CPT 50205: Kidney Needle Collection for Diagnostic Biopsy

    CPT-50220-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50220: Partial or Complete Nephrectomy, Kidney Removal

    CPT-50230-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50230: Nephrectomy, Kidney Removal

    CPT-50234-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50234: Nephrectomy, Kidney Removal

    CPT-50236-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50236: Nephrectomy (Kidney Removal)

    CPT-50240-NEPHRECTOMY-KIDNEY-REMOVAL

    CPT 50240: Nephrectomy, Kidney Removal

    CPT-50250-KIDNEY-CRYOABLATION-CRYOSURGERY

    CPT 50250: Kidney Cryoablation/Cryosurgery

    CPT-50280-RENAL-CYST-EXCISION-OPEN-DEROOFING

    CPT 50280: Excision/Removal of Renal Surface Cyst(s)

    CPT-50290-EXCISION-KIDNEY-SURROUNDING-TISSUE-CYST

    CPT 50290: Excision of Perirenal Cyst

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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