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    OpenPayerBilling CodesExcision Procedures on the PancreasCPT cpt-48160-pancreatectomy-with-pancreatic-tissue-or-islet-transplant
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    CPT 48160: Pancreatectomy with Islet Cell Harvest and Transplant

    CPT code 48160 describes surgical removal of all or part of the pancreas with harvesting and transplantation of pancreatic tissue or islet cells, a pancreatectomy with islet cell harvest and autotransplantation procedure; service type: operative/surgical; typical site of service: inpatient hospital or specialized surgical center (operating room) with possible subsequent inpatient monitoring.

    For related coverage guidance, see recent payer policy updates: Achalasia and Gastroesophageal Reflux Disease (GERD) - Minimally Invasive Procedures - Medical Policy, Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Percutaneous Electrical Nerve Field Stimulation for Disorders of Gut-Brain Interaction.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 45-year-old patient with brittle type 1 diabetes and recurrent severe hypoglycemic events undergoes pancreatectomy with islet autotransplantation. The patient is evaluated by a multidisciplinary team including transplant surgery, endocrinology, and anesthesia. Preoperative workup includes metabolic stabilization, imaging to assess pancreatic anatomy, infectious disease screening, and discussion of risks and benefits. In the operating room, the surgeon performs removal of the diseased pancreas (total or partial), harvests pancreatic tissue and isolates islet cells in a specialized laboratory, then transplants islets typically into the hepatic portal vein or into abdominal tissue depending on protocol. Postoperative care involves intensive monitoring for graft function, glucose management with insulin or other agents, anticoagulation as indicated, and surveillance for surgical complications such as bleeding, infection, or portal vein thrombosis. Follow-up includes serial measurement of C-peptide, hemoglobin A1c, and adjustments to diabetes therapy based on islet function.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    48160Removal of pancreas, with harvest and transplantation of pancreatic tissue or islet cellsPrimary procedure — pancreatectomy with islet harvest and transplantation
    38207Bone marrow or stem cell harvesting for transplantation; autologousRelated laboratory/harvest workflow analogue — documents tissue harvesting procedures when applicable to transplant workflows
    88305Surgical pathology, gross and microscopic examinationPathology evaluation of resected pancreatic tissue to assess disease and viability
    36415Collection of venous blood by venipunctureRoutine preoperative and postoperative laboratory monitoring including glucose and immunologic assays
    36514Insertion of peripherally inserted central venous catheter (PICC)Vascular access frequently used for prolonged IV therapy, immunosuppression, or lab draws in the perioperative period
    76937Ultrasound guidance for vascular accessImaging guidance for portal vein or hepatic access during islet infusion when percutaneous approaches are used

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    207L00000X
    207RC0000X
    376K00000X
    2278P4000X
    2084P0015X
    363LP0200X
    335U00000X

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    C25.0Malignant neoplasm of head of pancreas
    C25.1Malignant neoplasm of body of pancreas
    C25.2Malignant neoplasm of tail of pancreas
    C25.3Malignant neoplasm of pancreatic duct
    C25.4Malignant neoplasm of endocrine pancreas
    C25.7Malignant neoplasm of other parts of pancreas
    C25.8Malignant neoplasm of overlapping sites of pancreas
    C25.9Malignant neoplasm of pancreas, unspecified
    D73.5Infarction of spleen
    E10.65Type 1 diabetes mellitus with hyperglycemia

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Achalasia and Gastroesophageal Reflux Disease (GERD) - Minimally Invasive Procedures - Medical PolicyHealth-New-England2027-02-01
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Percutaneous Electrical Nerve Field Stimulation for Disorders of Gut-Brain Interactionpremerabluecrossofwashington2026-11-06
    Percutaneous electrical nerve field stimulation for disorders of gut-brain interactionpremerabluecrossofwashington2026-11-06
    Percutaneous Electrical Nerve Field Stimulation for Disorders of Gut-Brain Interactionpremerabluecrossofwashington2026-11-06
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01

    Related Codes

    CPT-48100-OPEN-SURGICAL-PANCREATIC-BIOPSY-PATHOLOGY-SAMPLE

    CPT 48100: Open Biopsy of Pancreatic Lesion

    CPT-48102-PERCUTANEOUS-PANCREATIC-NEEDLE-BIOPSY-PATHOLOGY

    CPT 48102: Percutaneous Needle Biopsy of Pancreas

    CPT-48105-PANCREATIC-RESECTION-DEBRIDEMENT-ACUTE-NECROTIZING-PANCREATITIS

    CPT 48105: Pancreatic Resection and Debridement for Necrotizing Pancreatitis

    CPT-48120-PANCREATIC-LESION-EXCISION

    CPT 48120: Excision of Lesion of Pancreas

    CPT-48140-DISTAL-PANCREATECTOMY-WITHOUT-PANCREATICOJEJUNOSTOMY

    CPT 48140: Distal Pancreatectomy with or without Splenectomy

    CPT-48145-DISTAL-PANCREATECTOMY-WITH-OR-WITHOUT-SPLENECTOMY

    CPT 48145: Distal Pancreatectomy With or Without Splenectomy

    CPT-48146-NEAR-TOTAL-PANCREATECTOMY

    CPT 48146: Near Total Pancreatectomy

    CPT-48148-AMPULLA-OF-VATER-REMOVAL-AMPULLECTOMY

    CPT 48148: Removal of the Ampulla of Vater

    CPT-48150-PANCREATICODUODENECTOMY-PYLORUS-RESECTING

    CPT 48150: Pancreaticoduodenectomy (Whipple) with Reconstruction

    CPT-48152-SUBTOTAL-PANCREATECTOMY-DUODENECTOMY-WITH-RECONSTRUCTION-NO-PANCREATICOJEJUNOSTOMY

    CPT 48152: Pancreaticoduodenectomy (Whipple) without Pancreaticojejunostomy

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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