CPT code 48153 describes an extensive pancreaticoduodenal resection with reconstruction of biliary and pancreatic drainage. This complex surgical procedure is performed for significant pancreatic and periampullary disease and is an important inpatient surgical code nationally due to its high resource utilization, perioperative risk, and implications for surgical quality and hospital reimbursement. Key payers covered in typical analyses include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will learn the clinical scope and operative intent behind the code, the typical inpatient surgical setting and resource needs, and which stakeholders commonly reimburse the service. The publication also summarizes benchmarking and policy context where available, including common billing practices, expected sites of service, and factors that influence coding and payment for major pancreatic resections. Data not available in the input is noted where applicable, and readers will find a concise reference for clinical documentation elements that align with the procedure description and for interpreting the code within inpatient surgical service lines.