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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the PancreasCPT cpt-48148-ampulla-of-vater-removal-ampullectomy
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    CPT 48148: Removal of the Ampulla of Vater

    Medicare pays $1187 on average nationally for this procedure.

    CPT code 48148 describes surgical removal of the ampulla of Vater (ampullectomy), a procedure to excise the combined opening of the common bile duct and pancreatic duct; the service is a surgical operative procedure typically performed in an inpatient or ambulatory surgical center setting and involves resection of ampullary tissue to address neoplastic or obstructive ampullary pathology.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 55–75 year-old individual presenting with obstructive jaundice, recurrent cholangitis, or periampullary neoplasm identified on imaging (CT/MRI) or endoscopic evaluation. After diagnostic workup including liver function tests, abdominal imaging, and endoscopic retrograde cholangiopancreatography (ERCP) or endoscopic ultrasound (EUS), the surgical team elects for resection of the ampulla of Vater when the lesion is localized to the ampullary region and not amenable to local endoscopic therapy or when malignancy is suspected and local excision is appropriate.

    Preoperative workflow includes multidisciplinary evaluation (gastroenterology, surgical oncology, anesthesia), informed consent, optimization of comorbidities, and marking of planned site of resection. Intraoperative workflow involves general anesthesia, exposure of the second portion of the duodenum, identification of the ampulla and intraduodenal ducts, careful dissection and excision of the ampullary complex with attention to the common bile duct and pancreatic duct confluence, and reconstruction of ductal drainage (e.g., ductal reimplantation or local anastomosis). Postoperative care focuses on monitoring for bile leak, pancreatitis, hemorrhage, and sepsis, with serial labs and imaging as indicated. Pathology evaluation of the specimen guides any further oncologic therapy.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43260Endoscopic, transgastric or transduodenal excision of lesion(s) of the ampulla, includes intraduodenal sphincterotomy when performedEndoscopic ampullectomy alternative or preceding diagnostic/therapeutic approach; may be used when lesion is amenable to endoscopic removal.
    47562Laparoscopy, surgical; cholecystectomyPerformed concurrently or prior when gallbladder pathology or biliary obstruction is present; may be done for biliary drainage.
    48260Excision or destruction of lesion of bile duct, open, single or multiplePerformed when additional bile duct lesions require direct excision during the same operative session.
    43258Endoscopic retrograde cholangiopancreatography, with sphincterotomy and/or dilationOften performed preoperatively for diagnostic visualization, bile duct stenting, or to decompress biliary obstruction.
    48150Local excision or destruction of lesion(s) of the duodenumRelated for adjacent duodenal lesions or when wider local excision is necessary.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    333600000X
    207K00000X
    207L00000X
    2084V0102X
    146E00000X
    261QM1200X
    204F00000X
    343900000X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    C24.0Malignant neoplasm of extrahepatic bile duct
    C24.1Malignant neoplasm of ampulla of Vater
    C25.8Malignant neoplasm of overlapping sites of pancreas
    C25.9Malignant neoplasm of pancreas, unspecified
    D13.4Benign neoplasm of liver
    I85.01Esophageal varices with bleeding
    K29.70Gastritis, unspecified, without bleeding
    K29.71Gastritis, unspecified, with bleeding
    K80.10Calculus of gallbladder with chronic cholecystitis without obstruction
    K80.20Calculus of gallbladder without cholecystitis without obstruction

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-48100-OPEN-SURGICAL-PANCREATIC-BIOPSY-PATHOLOGY-SAMPLE

    CPT 48100: Open Biopsy of Pancreatic Lesion

    CPT-48102-PERCUTANEOUS-PANCREATIC-NEEDLE-BIOPSY-PATHOLOGY

    CPT 48102: Percutaneous Needle Biopsy of Pancreas

    CPT-48105-PANCREATIC-RESECTION-DEBRIDEMENT-ACUTE-NECROTIZING-PANCREATITIS

    CPT 48105: Pancreatic Resection and Debridement for Necrotizing Pancreatitis

    CPT-48120-PANCREATIC-LESION-EXCISION

    CPT 48120: Excision of Lesion of Pancreas

    CPT-48140-DISTAL-PANCREATECTOMY-WITHOUT-PANCREATICOJEJUNOSTOMY

    CPT 48140: Distal Pancreatectomy with or without Splenectomy

    CPT-48145-DISTAL-PANCREATECTOMY-WITH-OR-WITHOUT-SPLENECTOMY

    CPT 48145: Distal Pancreatectomy With or Without Splenectomy

    CPT-48146-NEAR-TOTAL-PANCREATECTOMY

    CPT 48146: Near Total Pancreatectomy

    CPT-48150-PANCREATICODUODENECTOMY-PYLORUS-RESECTING

    CPT 48150: Pancreaticoduodenectomy (Whipple) with Reconstruction

    CPT-48152-SUBTOTAL-PANCREATECTOMY-DUODENECTOMY-WITH-RECONSTRUCTION-NO-PANCREATICOJEJUNOSTOMY

    CPT 48152: Pancreaticoduodenectomy (Whipple) without Pancreaticojejunostomy

    CPT-48153-PANCREATICODUODENAL-RESECTION-WITH-RECONSTRUCTION

    CPT 48153: Pylorus-Preserving Pancreaticoduodenectomy

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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