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    OpenPayerBilling CodesExcision Procedures on the PancreasCPT cpt-48105-pancreatic-resection-debridement-acute-necrotizing-pancreatitis
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    CPT 48105: Pancreatic Resection and Debridement for Necrotizing Pancreatitis

    Medicare pays $2578 on average nationally for this procedure.

    CPT code 48105 describes surgical resection and debridement of pancreatic tissue performed for acute necrotizing pancreatitis, a procedure-type service typically provided in an inpatient operating room or surgical suite for patients requiring removal of necrotic or infected pancreatic tissue to control sepsis and complications.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult hospitalized with severe acute necrotizing pancreatitis complicated by infected necrosis, persistent organ dysfunction, or unresolving sepsis despite maximal medical therapy. The patient often presents with severe epigastric abdominal pain, fever, leukocytosis, hypotension, and evidence of pancreatic necrosis on contrast-enhanced CT. Initial management includes aggressive fluid resuscitation, broad-spectrum antibiotics if infection is suspected, endoscopic or percutaneous drainage when appropriate, and multidisciplinary review by surgery, gastroenterology, and interventional radiology. When necrosis is extensive, clearly demarcated, and associated with persistent sepsis or failure of less invasive measures, the surgical team performs operative necrosectomy with pancreatic resection and debridement using CPT 48105. The procedure typically occurs in the operating room under general anesthesia with possible postoperative ICU care. Typical workflow: admission → imaging and supportive care → percutaneous/endoscopic drainage if indicated → multidisciplinary reassessment → informed consent for operative debridement/resection → CPT 48105 performed → postoperative critical care, antibiotics, and monitoring for complications such as hemorrhage, fistula, or new organ dysfunction.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    48100Pancreatic necrosectomy; without pancreatic resectionAlternative surgical debridement procedure when resection is not performed; may be used for less extensive necrosis.
    48140PancreaticojejunostomyReconstruction performed when pancreatic ductal reconstruction is required following resection during CPT 48105.
    47562Laparoscopy, surgical; cholecystectomy with cholangiographyFrequently performed prior to or concurrent with pancreatic surgery when gallstone pancreatitis is the etiology.
    49406Insertion of peritoneal drain (percutaneous)Used in initial or adjunctive drainage of infected pancreatic fluid collections prior to or after CPT 48105.
    32551Tube thoracostomy, includes water seal (e.g., for empyema)Performed when pleural complications such as effusion or empyema occur in severe pancreatitis and require drainage.
    99291Critical care, evaluation and management of the critically ill or unstable patient; first 30-74 minutesCommonly billed for postoperative ICU management of patients after CPT 48105 when critical care is required.

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207L00000X
    208800000X
    208000000X
    207K00000X
    213ES0103X
    207RC0000X
    2080P0203X
    367H00000X

    Related ICD-10-CM Codes

    18 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    B95.61Methicillin susceptible Staphylococcus aureus infection as the cause of diseases classified elsewhere
    E86.0Dehydration
    I26.99Other pulmonary embolism without acute cor pulmonale
    I50.9Heart failure, unspecified
    I82.409Acute embolism and thrombosis of unspecified deep veins of unspecified lower extremity
    J95.811Postprocedural pneumothorax
    J96.00Acute respiratory failure, unspecified whether with hypoxia or hypercapnia
    K57.32Diverticulitis of large intestine without perforation or abscess without bleeding
    K65.0Generalized (acute) peritonitis

    Showing 1–10 of 18

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-48100-OPEN-SURGICAL-PANCREATIC-BIOPSY-PATHOLOGY-SAMPLE

    CPT 48100: Open Biopsy of Pancreatic Lesion

    CPT-48102-PERCUTANEOUS-PANCREATIC-NEEDLE-BIOPSY-PATHOLOGY

    CPT 48102: Percutaneous Needle Biopsy of Pancreas

    CPT-48120-PANCREATIC-LESION-EXCISION

    CPT 48120: Excision of Lesion of Pancreas

    CPT-48140-DISTAL-PANCREATECTOMY-WITHOUT-PANCREATICOJEJUNOSTOMY

    CPT 48140: Distal Pancreatectomy with or without Splenectomy

    CPT-48145-DISTAL-PANCREATECTOMY-WITH-OR-WITHOUT-SPLENECTOMY

    CPT 48145: Distal Pancreatectomy With or Without Splenectomy

    CPT-48146-NEAR-TOTAL-PANCREATECTOMY

    CPT 48146: Near Total Pancreatectomy

    CPT-48148-AMPULLA-OF-VATER-REMOVAL-AMPULLECTOMY

    CPT 48148: Removal of the Ampulla of Vater

    CPT-48150-PANCREATICODUODENECTOMY-PYLORUS-RESECTING

    CPT 48150: Pancreaticoduodenectomy (Whipple) with Reconstruction

    CPT-48152-SUBTOTAL-PANCREATECTOMY-DUODENECTOMY-WITH-RECONSTRUCTION-NO-PANCREATICOJEJUNOSTOMY

    CPT 48152: Pancreaticoduodenectomy (Whipple) without Pancreaticojejunostomy

    CPT-48153-PANCREATICODUODENAL-RESECTION-WITH-RECONSTRUCTION

    CPT 48153: Pylorus-Preserving Pancreaticoduodenectomy

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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