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    v1.0.31
    OpenPayerBilling CodesExcision Procedures on the PancreasCPT cpt-48120-pancreatic-lesion-excision
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    CPT 48120: Excision of Lesion of Pancreas

    Medicare pays $1054 on average nationally for this procedure.

    CPT code 48120 describes surgical excision of a lesion of the pancreas, a pancreatic lesion resection procedure typically performed in the operating room as an open or laparoscopic pancreatic surgery to remove focal neoplasms or masses; the entry clarifies the procedure intent, operative service type, and typical inpatient or outpatient surgical setting for clinical and billing reference.

    For related coverage guidance, see recent payer policy updates: Achalasia and Gastroesophageal Reflux Disease (GERD) - Minimally Invasive Procedures - Medical Policy, Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Percutaneous Electrical Nerve Field Stimulation for Disorders of Gut-Brain Interaction.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult referred to a surgical oncology team for resection of a focal pancreatic lesion detected on imaging. Presentation commonly includes abdominal pain, unexplained weight loss, jaundice, or incidental finding on CT or MRI. Preoperative workup includes cross-sectional imaging (contrast-enhanced CT or MRI), endoscopic ultrasound with possible biopsy, laboratory evaluation including liver function tests and tumor markers (eg, CA 19-9), and anesthesia assessment.

    The operation coded by 48120 involves surgical removal of a lesion of the pancreas and may be performed via open or minimally invasive approaches depending on lesion location and patient factors. The typical site of service is an inpatient operating room within an acute care hospital; select cases may be performed in ambulatory surgical centers when criteria are met and observation or short-stay admission is planned. Perioperative workflow includes preoperative consent and documentation of indication, intraoperative operative note describing lesion size/location, approach, extent of resection, and reconstruction if performed, and postoperative progress notes documenting recovery, complications, and discharge planning. Pathology specimen handling and final pathology report are part of the clinical course.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    48140Pancreatectomy, distal subtotal, with or without splenectomyPerformed when lesion location necessitates distal pancreatectomy rather than localized lesion excision.
    48145Partial pancreatectomy, with pancreatoenterostomyPerformed when resection requires reconstruction of pancreatic drainage.
    47562Laparoscopy, surgical; cholecystectomyMay be performed concomitantly if symptomatic gallbladder disease or biliary stent management is required.
    43238Upper gastrointestinal endoscopy with biopsy, single or multiplePerformed preoperatively via endoscopic ultrasound-guided biopsy to obtain tissue diagnosis.
    88309Surgical pathology, gross and microscopic examinationAssociated with analysis of the resected pancreatic lesion specimen.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    208600000X
    207L00000X
    208C00000X
    207LA0401X
    3104A0630X
    193200000X
    224Z00000X

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Achalasia and Gastroesophageal Reflux Disease (GERD) - Minimally Invasive Procedures - Medical PolicyHealth-New-England2027-02-01
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Percutaneous Electrical Nerve Field Stimulation for Disorders of Gut-Brain Interactionpremerabluecrossofwashington2026-11-06
    Percutaneous electrical nerve field stimulation for disorders of gut-brain interactionpremerabluecrossofwashington2026-11-06
    Percutaneous Electrical Nerve Field Stimulation for Disorders of Gut-Brain Interactionpremerabluecrossofwashington2026-11-06
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01

    Related Codes

    CPT-48100-OPEN-SURGICAL-PANCREATIC-BIOPSY-PATHOLOGY-SAMPLE

    CPT 48100: Open Biopsy of Pancreatic Lesion

    CPT-48102-PERCUTANEOUS-PANCREATIC-NEEDLE-BIOPSY-PATHOLOGY

    CPT 48102: Percutaneous Needle Biopsy of Pancreas

    CPT-48105-PANCREATIC-RESECTION-DEBRIDEMENT-ACUTE-NECROTIZING-PANCREATITIS

    CPT 48105: Pancreatic Resection and Debridement for Necrotizing Pancreatitis

    CPT-48140-DISTAL-PANCREATECTOMY-WITHOUT-PANCREATICOJEJUNOSTOMY

    CPT 48140: Distal Pancreatectomy with or without Splenectomy

    CPT-48145-DISTAL-PANCREATECTOMY-WITH-OR-WITHOUT-SPLENECTOMY

    CPT 48145: Distal Pancreatectomy With or Without Splenectomy

    CPT-48146-NEAR-TOTAL-PANCREATECTOMY

    CPT 48146: Near Total Pancreatectomy

    CPT-48148-AMPULLA-OF-VATER-REMOVAL-AMPULLECTOMY

    CPT 48148: Removal of the Ampulla of Vater

    CPT-48150-PANCREATICODUODENECTOMY-PYLORUS-RESECTING

    CPT 48150: Pancreaticoduodenectomy (Whipple) with Reconstruction

    CPT-48152-SUBTOTAL-PANCREATECTOMY-DUODENECTOMY-WITH-RECONSTRUCTION-NO-PANCREATICOJEJUNOSTOMY

    CPT 48152: Pancreaticoduodenectomy (Whipple) without Pancreaticojejunostomy

    CPT-48153-PANCREATICODUODENAL-RESECTION-WITH-RECONSTRUCTION

    CPT 48153: Pylorus-Preserving Pancreaticoduodenectomy

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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