CPT code 38220 represents a diagnostic bone marrow aspiration, in which a long, large-bore needle is inserted into the sternum or pelvic bone to aspirate marrow for laboratory analysis. This code is used nationally to capture a common hematologic diagnostic procedure essential for evaluating marrow disorders such as anemias, leukemias, and myelodysplastic syndromes. Accurate coding supports appropriate claims processing and clinical documentation across inpatient and outpatient settings.

Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, United Healthcare, and Medicare. Readers will find an overview of clinical context and operative setting for the procedure, comparisons and benchmark considerations across major commercial payers and Medicare, and guidance on closely related codes used when biopsy or combined aspiration/biopsy services are performed. The publication highlights common claim relationships between 38220 and related CPT codes for bone marrow biopsy and combined procedures, and outlines typical diagnostic indications tied to the service.

This material is intended for billing managers, coding professionals, and clinical staff seeking a concise national overview of CPT code 38220, including service definitions, payer coverage context, and where to look for differences in coding and reimbursement practices among major payers.