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    v1.0.31
    OpenPayerBilling CodesBone Marrow or Stem Cell Services/ProceduresCPT cpt-38213-hpc-solution-preparation-platelet-reduction
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    CPT 38213: Hematopoietic Progenitor Cell Preparation to Reduce Platelets

    CPT code 38213 describes preparation of a hematopoietic progenitor cell (HPC) solution to reduce residual platelets and prevent clumping, a laboratory/processing service performed on collected stem cell products prior to infusion or cryopreservation; typical service type is cell product processing and the usual site of service is a hospital-based laboratory or transplantation center where apheresis products are handled.

    For related coverage guidance, see recent payer policy updates: Bendamustine Products Coverage Criteria, T-Cell Lymphoma Agents: Beleodaq, Istodax, Lymphir, Poteligeo, and Romidepsin, Brentuximab Vedotin (Adcetris®) Coverage Criteria.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient scenario involves an adult or pediatric patient undergoing collection of hematopoietic progenitor cells (HPCs) by apheresis for autologous or allogeneic hematopoietic stem cell transplantation. The patient may have a diagnosis such as multiple myeloma, lymphoma, leukemia in remission, or a bone marrow failure disorder and has undergone mobilization with granulocyte‑colony stimulating factor (G‑CSF) with or without chemotherapy. During the apheresis session the collected product requires laboratory processing to reduce platelet numbers and prevent platelet clumping prior to storage, testing, or infusion. A transfusion medicine or apheresis nurse/technologist prepares the HPC solution in a clean laboratory or blood bank environment. The workflow: patient arrives to the apheresis unit, vascular access is confirmed (peripheral or central), apheresis collection is performed, the collected bag is transported to the cell processing area, a trained provider performs platelet reduction and clump prevention procedures (sedimentation, centrifugation, filtration, or validated platelet‑reduction methods), final product labeling and QC testing are completed, and the processed HPC product is either returned to the clinical unit for infusion or moved to cryopreservation. Typical site of service is an outpatient apheresis center, hospital blood bank/cell processing lab, or ambulatory infusion center depending on institutional setup. Common clinical roles involved include hematologist/oncologist, transfusion medicine physician, apheresis nurse/technologist, and cell processing laboratory staff.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    38205Apheresis; therapeutic, for removal of cellular elements (e.g., plasma exchange is separate)Performed prior to 38213 when HPCs are collected by apheresis; collection is the source product that requires subsequent platelet reduction.
    38207Harvest of hematopoietic progenitor cells (HPC); per collection, for autologous transplantOften performed in the same episode of care; 38207 documents the actual harvest while 38213 documents subsequent processing to reduce platelets/clumping.
    38208Harvest of hematopoietic progenitor cells (HPC); for allogeneic transplant, per donorUsed for donor collections where 38213 processing may follow prior to infusion or cryopreservation.
    38212Processing of hematopoietic progenitor cells, other than enumeration and viability testing, per unitRelated processing CPT; 38213 is specific for platelet reduction/clump prevention and may be reported in conjunction based on payer rules.
    86999Unlisted immunology/hematology procedureUsed rarely when a specific processing step is not described by an existing code; 38213 should be used when applicable to avoid unlisted coding.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    208D00000X
    363L00000X
    246ZG0701X
    163WP0000X
    2278S1500X
    207YX0007X
    207ZP0007X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    B20Human immunodeficiency virus [HIV] disease
    C81.90Hodgkin lymphoma, unspecified, unspecified site
    C82.90Follicular lymphoma, unspecified, unspecified site
    C83.90Non-follicular (diffuse) lymphoma, unspecified, unspecified site
    C84.90Mature T/NK-cell lymphomas, unspecified, unspecified site
    C85.90Non-Hodgkin lymphoma, unspecified, unspecified site
    C90.00Multiple myeloma not having achieved remission
    C91.00Acute lymphoblastic leukemia not having achieved remission
    C92.00Acute myeloblastic leukemia, not having achieved remission
    C95.00Acute leukemia of unspecified cell type not having achieved remission

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Bendamustine Products Coverage Criteriablue cross blue shield - tennessee2027-01-30
    T-Cell Lymphoma Agents: Beleodaq, Istodax, Lymphir, Poteligeo, and RomidepsinMass General Brigham Health Plan2027-01-04
    Brentuximab Vedotin (Adcetris®) Coverage Criteriablue cross blue shield - tennessee2026-12-31
    Pemetrexed Coverageblue cross blue shield - tennessee2026-12-31
    Tumor Treatment Fields - Medical PolicyHealth-New-England2026-12-01
    Extracorporeal PhotopheresisCigna2026-11-15
    VonvendiCigna2026-11-15
    Hematology - AphexdaCigna2026-11-15
    Extracorporeal PhotopheresisCigna2026-11-15
    Yartemlea (narsoplimab-wuug) Coverage for TA-TMANeighborhood Health Plan of Rhode Island2026-11-01

    Related Codes

    CPT-38204-DONOR-SEARCH-HPC-ACQUISITION-MANAGEMENT

    CPT 38204: Donor Search and Hematopoietic Progenitor Cell Acquisition

    CPT-38205-APHERESIS-HPC-PERIPHERAL-BLOOD-HARVEST

    CPT 38205: Apheresis Hematopoietic Progenitor Cell Harvest

    CPT-38206-AUTOLOGOUS-HPC-APHERESIS-COLLECTION

    CPT 38206: Autologous Hematopoietic Progenitor Cell Apheresis

    CPT-38207-HEMATOPOIETIC-PROGENITOR-CELL-PRESERVATION-STORAGE

    CPT 38207: Management of Hematopoietic Progenitor Cell Preservation

    CPT-38208-THAW-PREPARATION-HEMATOPOIETIC-PROGENITOR-CELLS

    CPT 38208: Thawing of Previously Frozen Hematopoietic Progenitor Cells

    CPT-38209-HPC-THAWING-AND-WASHING-FOR-TRANSPLANTATION

    CPT 38209: Thaw and Wash Hematopoietic Progenitor Cells for Transplant

    CPT-38210-T-CELL-DEPLETED-HEMATOPOIETIC-PROGENITOR-CELL-PREPARATION

    CPT 38210: T-Cell–Reduced Hematopoietic Progenitor Cell Preparation

    CPT-38211-HEMATOPOIETIC-PROGENITOR-CELL-TUMOR-REDUCTION-PROCESSING

    CPT 38211: Hematopoietic Progenitor Cell Enrichment and Tumor Depletion

    CPT-38212-HPC-RED-CELL-DEPLETION-PREPARATION

    CPT 38212: HPC Red Cell Depletion for Transplant Preparation

    CPT-38214-HPC-MINIMAL-PLASMA-VOLUME-PREPARATION

    CPT 38214: Preparation of HPCs to Minimal Plasma Volume

    Showing 1–10 of 20

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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