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    v1.0.31
    OpenPayerBilling CodesBone Marrow or Stem Cell Services/ProceduresCPT cpt-38211-hematopoietic-progenitor-cell-tumor-reduction-processing
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    CPT 38211: Hematopoietic Progenitor Cell Enrichment and Tumor Depletion

    CPT code 38211 describes preparation of hematopoietic progenitor cells (HPCs) using combined enrichment and depletion techniques to remove as many tumor cells as possible prior to transplant; this is a therapeutic cell-processing service performed in a specialized laboratory or cell-processing facility associated with hematopoietic stem cell transplantation and apheresis programs.

    For related coverage guidance, see recent payer policy updates: Bendamustine Products Coverage Criteria, T-Cell Lymphoma Agents: Beleodaq, Istodax, Lymphir, Poteligeo, and Romidepsin, Brentuximab Vedotin (Adcetris®) Coverage Criteria.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 45–65-year-old adult with a hematologic malignancy such as non-Hodgkin lymphoma or acute myeloid leukemia who is scheduled for autologous or allogeneic hematopoietic progenitor cell (HPC) transplantation. The workflow begins with oncology evaluation and staging, mobilization of peripheral blood stem cells with growth factors (with or without plerixafor), and apheresis collection of HPCs. The collected product is transported to the cell processing laboratory where the provider performs combined enrichment and depletion techniques to remove tumor cells from the graft (tumor cell purging) per protocol. Processed HPCs are tested for cell counts, viability, infectious disease markers, and sterility. The final product is released for cryopreservation or immediate infusion. Documentation includes indication for purging, method(s) used, percent tumor cell reduction when available, product volume and cell counts, personnel and facility identifiers, and date/time of processing. Typical site of service is an academic medical center or hospital-based cell processing laboratory supporting transplant programs.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    38205Bone marrow harvest for transplantation (separate procedure)Performed when marrow-derived progenitor cells are collected instead of or in addition to peripheral blood HPCs; may precede cell processing.
    38206Peripheral blood stem cell harvest for transplantation, allogeneic, HPC, apheresis (separate procedure)This code describes the apheresis collection procedure that provides the product subsequently processed under 38211.
    38207Peripheral blood stem cell harvest for transplantation, autologous, HPC, apheresis (separate procedure)Autologous apheresis collection commonly precedes tumor cell purging using 38211.
    38212Processing autologous cellular therapy product; total nucleated cell reduction, washing, and concentration (separate procedure)Other processing techniques that may be performed in the laboratory and can be reported in conjunction with or instead of purging depending on payer rules.
    86850Cell viability testingLaboratory testing performed on the HPC product after processing to assess cell viability before release for infusion.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    2080P0207X
    3336C0002X
    2472E0500X
    2083A0100X
    2083X0100X
    363AS0400X
    103TP0814X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    B20Human immunodeficiency virus [HIV] disease
    C81.90Hodgkin lymphoma, unspecified, unspecified site
    C83.30Diffuse large B-cell lymphoma, unspecified site
    C84.90Mature T/NK-cell lymphomas, unspecified, unspecified site
    C85.80Other specified types of non-Hodgkin lymphoma, unspecified site
    C90.00Multiple myeloma not having achieved remission
    C90.02Multiple myeloma in relapse
    C91.00Acute lymphoblastic leukemia not having achieved remission
    C91.01Acute lymphoblastic leukemia, in remission
    C91.02Acute lymphoblastic leukemia, in relapse

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Bendamustine Products Coverage Criteriablue cross blue shield - tennessee2027-01-30
    T-Cell Lymphoma Agents: Beleodaq, Istodax, Lymphir, Poteligeo, and RomidepsinMass General Brigham Health Plan2027-01-04
    Brentuximab Vedotin (Adcetris®) Coverage Criteriablue cross blue shield - tennessee2026-12-31
    Pemetrexed Coverageblue cross blue shield - tennessee2026-12-31
    Tumor Treatment Fields - Medical PolicyHealth-New-England2026-12-01
    Extracorporeal PhotopheresisCigna2026-11-15
    VonvendiCigna2026-11-15
    Hematology - AphexdaCigna2026-11-15
    Extracorporeal PhotopheresisCigna2026-11-15
    Yartemlea (narsoplimab-wuug) Coverage for TA-TMANeighborhood Health Plan of Rhode Island2026-11-01

    Related Codes

    CPT-38204-DONOR-SEARCH-HPC-ACQUISITION-MANAGEMENT

    CPT 38204: Donor Search and Hematopoietic Progenitor Cell Acquisition

    CPT-38205-APHERESIS-HPC-PERIPHERAL-BLOOD-HARVEST

    CPT 38205: Apheresis Hematopoietic Progenitor Cell Harvest

    CPT-38206-AUTOLOGOUS-HPC-APHERESIS-COLLECTION

    CPT 38206: Autologous Hematopoietic Progenitor Cell Apheresis

    CPT-38207-HEMATOPOIETIC-PROGENITOR-CELL-PRESERVATION-STORAGE

    CPT 38207: Management of Hematopoietic Progenitor Cell Preservation

    CPT-38208-THAW-PREPARATION-HEMATOPOIETIC-PROGENITOR-CELLS

    CPT 38208: Thawing of Previously Frozen Hematopoietic Progenitor Cells

    CPT-38209-HPC-THAWING-AND-WASHING-FOR-TRANSPLANTATION

    CPT 38209: Thaw and Wash Hematopoietic Progenitor Cells for Transplant

    CPT-38210-T-CELL-DEPLETED-HEMATOPOIETIC-PROGENITOR-CELL-PREPARATION

    CPT 38210: T-Cell–Reduced Hematopoietic Progenitor Cell Preparation

    CPT-38212-HPC-RED-CELL-DEPLETION-PREPARATION

    CPT 38212: HPC Red Cell Depletion for Transplant Preparation

    CPT-38213-HPC-SOLUTION-PREPARATION-PLATELET-REDUCTION

    CPT 38213: Hematopoietic Progenitor Cell Preparation to Reduce Platelets

    CPT-38214-HPC-MINIMAL-PLASMA-VOLUME-PREPARATION

    CPT 38214: Preparation of HPCs to Minimal Plasma Volume

    Showing 1–10 of 20

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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