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    v1.0.31
    OpenPayerBilling CodesBone Marrow or Stem Cell Services/ProceduresCPT cpt-38210-t-cell-depleted-hematopoietic-progenitor-cell-preparation
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    CPT 38210: T-Cell–Reduced Hematopoietic Progenitor Cell Preparation

    CPT code 38210 describes preparation of hematopoietic progenitor cells (HPCs) modified to have minimal numbers of T cells to reduce risk of graft rejection; this is a specialized cell processing service performed in a cell therapy / apheresis laboratory or similar specialized hospital outpatient or inpatient setting prior to hematopoietic stem cell transplantation or infusion.

    For related coverage guidance, see recent payer policy updates: Bendamustine Products Coverage Criteria, T-Cell Lymphoma Agents: Beleodaq, Istodax, Lymphir, Poteligeo, and Romidepsin, Brentuximab Vedotin (Adcetris®) Coverage Criteria.

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    Clinical & Coding Specifications

    Clinical Context

    A 42-year-old patient with acute myeloid leukemia (AML) achieves remission after induction chemotherapy and is scheduled for an allogeneic hematopoietic stem cell transplant from an HLA-matched related donor. The transplant team orders preparation of the donor hematopoietic progenitor cell (HPC) product to reduce T-lymphocyte content (T-cell depletion) to minimize the risk of graft-versus-host disease (GVHD) and immunologic rejection. The donor undergoes mobilization and apheresis at an outpatient apheresis suite within an academic medical center or specialized transplant center. Collected peripheral blood stem cell units are transferred to the cellular therapy laboratory where trained laboratory technologists and transfusion medicine specialists perform T-cell depletion procedures per institutional protocol, including methods such as CD34+ selection, positive selection of progenitor cells, or other techniques that produce a product with minimal T cells. The processed HPC product is tested for cell counts, viability, infectious disease markers, and sterility, then transported under controlled conditions to the transplant operating room or inpatient bone marrow transplant unit for infusion into the recipient. Typical site of service includes inpatient bone marrow transplant units, outpatient apheresis centers, and hospital-based cellular therapy laboratories. The clinical workflow includes donor evaluation and mobilization, apheresis collection, laboratory processing for T-cell reduction, quality control testing, product release, and infusion into the recipient with appropriate documentation at each step.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36511Collection of blood from apheresis for peripheral blood stem cell collection; allogeneic donorPerformed prior to processing; collection of HPCs that are then T-cell depleted.
    38205Bone marrow or blood-derived hematopoietic progenitor cell transplantation; mobilization, harvesting and reinfusion not specified (apheresis-related procedures)Represents related harvesting and transplantation services in the transplant pathway.
    38230Cellpheresis, therapeutic, for stem cell collection (apheresis)Alternate or adjunct apheresis procedure codes used for collection of cellular products for processing.
    88184Flow cytometry, CD34 cell enumerations (example)Laboratory testing performed on collected product to enumerate progenitor cells prior to release.
    36415Collection of venous blood by venipunctureOften performed for pre-procedure crossmatch and infectious disease testing of donor and recipient.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207L00000X
    2084P0800X
    390200000X
    207K00000X
    251F00000X
    363LP1700X
    2355S0801X
    374K00000X

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Bendamustine Products Coverage Criteriablue cross blue shield - tennessee2027-01-30
    T-Cell Lymphoma Agents: Beleodaq, Istodax, Lymphir, Poteligeo, and RomidepsinMass General Brigham Health Plan2027-01-04
    Brentuximab Vedotin (Adcetris®) Coverage Criteriablue cross blue shield - tennessee2026-12-31
    Pemetrexed Coverageblue cross blue shield - tennessee2026-12-31
    Tumor Treatment Fields - Medical PolicyHealth-New-England2026-12-01
    Extracorporeal PhotopheresisCigna2026-11-15
    VonvendiCigna2026-11-15
    Hematology - AphexdaCigna2026-11-15
    Extracorporeal PhotopheresisCigna2026-11-15
    Yartemlea (narsoplimab-wuug) Coverage for TA-TMANeighborhood Health Plan of Rhode Island2026-11-01

    Related Codes

    CPT-38204-DONOR-SEARCH-HPC-ACQUISITION-MANAGEMENT

    CPT 38204: Donor Search and Hematopoietic Progenitor Cell Acquisition

    CPT-38205-APHERESIS-HPC-PERIPHERAL-BLOOD-HARVEST

    CPT 38205: Apheresis Hematopoietic Progenitor Cell Harvest

    CPT-38206-AUTOLOGOUS-HPC-APHERESIS-COLLECTION

    CPT 38206: Autologous Hematopoietic Progenitor Cell Apheresis

    CPT-38207-HEMATOPOIETIC-PROGENITOR-CELL-PRESERVATION-STORAGE

    CPT 38207: Management of Hematopoietic Progenitor Cell Preservation

    CPT-38208-THAW-PREPARATION-HEMATOPOIETIC-PROGENITOR-CELLS

    CPT 38208: Thawing of Previously Frozen Hematopoietic Progenitor Cells

    CPT-38209-HPC-THAWING-AND-WASHING-FOR-TRANSPLANTATION

    CPT 38209: Thaw and Wash Hematopoietic Progenitor Cells for Transplant

    CPT-38211-HEMATOPOIETIC-PROGENITOR-CELL-TUMOR-REDUCTION-PROCESSING

    CPT 38211: Hematopoietic Progenitor Cell Enrichment and Tumor Depletion

    CPT-38212-HPC-RED-CELL-DEPLETION-PREPARATION

    CPT 38212: HPC Red Cell Depletion for Transplant Preparation

    CPT-38213-HPC-SOLUTION-PREPARATION-PLATELET-REDUCTION

    CPT 38213: Hematopoietic Progenitor Cell Preparation to Reduce Platelets

    CPT-38214-HPC-MINIMAL-PLASMA-VOLUME-PREPARATION

    CPT 38214: Preparation of HPCs to Minimal Plasma Volume

    Showing 1–10 of 20

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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