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    v1.0.31
    OpenPayerBilling CodesBone Marrow or Stem Cell Services/ProceduresCPT cpt-38204-donor-search-hpc-acquisition-management
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    CPT 38204: Donor Search and Hematopoietic Progenitor Cell Acquisition

    CPT code 38204 describes provider management of the search for a suitable donor and acquisition of hematopoietic progenitor cells (HPCs), a coordination service that includes identifying compatible donors and arranging collection of HPCs; service type: donor search and HPC acquisition coordination; typical site of service: transplant center or specialized hematology/oncology clinic coordinating donor procurement and collection.

    For related coverage guidance, see recent payer policy updates: Bendamustine Products Coverage Criteria, T-Cell Lymphoma Agents: Beleodaq, Istodax, Lymphir, Poteligeo, and Romidepsin, Brentuximab Vedotin (Adcetris®) Coverage Criteria.

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    Clinical & Coding Specifications

    Clinical Context

    A 42-year-old man with relapsed acute myeloid leukemia is evaluated for allogeneic hematopoietic progenitor cell (HPC) transplantation. The transplant program’s transplant physician and coordinator perform donor selection, HLA typing coordination, infectious disease screening, donor suitability review, and arrange collection logistics. The workflow includes: initial candidate assessment, donor registry search or related donor evaluation, obtaining informed consent from the donor, coordination with apheresis or bone marrow harvest teams, arranging cryopreservation and transportation of the graft, and documentation of donor compatibility and acquisition charges for billing under 38204. Typical site of service is an outpatient transplant center or hospital-based transplant program; donor collection often occurs in an ambulatory apheresis unit or operating room for marrow harvest. The patient has been medically optimized for transplant, and the provider documents donor identification, compatibility results, procurement plan, and any communications with registries and collection centers.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    38204Hematopoietic progenitor cell (HPC) acquisition; search for a suitable donor and acquisition of cells compatible with the recipientPrimary code describing provider management of donor search and acquisition — used to bill the transplant program for these services.
    38205Transplantation of hematopoietic progenitor cells; allogeneic, peripheral blood, unrelated donorMay be billed for the actual transplantation procedure that follows acquisition arranged under 38204.
    38206Transplantation of hematopoietic progenitor cells; allogeneic, bone marrow, unrelated donorUsed when the procured graft is bone marrow harvested surgically after donor acquisition coordination.
    38207Transplantation of hematopoietic progenitor cells; autologousRelevant when the patient undergoes autologous transplant instead of unrelated donor allogeneic transplant.
    38210Collection of peripheral blood progenitor cells, with cell preparation and transfusion, for transplantationRepresents the collection procedure (apheresis) that is coordinated and scheduled as part of the services billed with 38204.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208100000X
    207RH0000X
    208000000X
    363L00000X
    363A00000X
    225CX0006X
    246QC1000X
    364SC2300X

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Bendamustine Products Coverage Criteriablue cross blue shield - tennessee2027-01-30
    T-Cell Lymphoma Agents: Beleodaq, Istodax, Lymphir, Poteligeo, and RomidepsinMass General Brigham Health Plan2027-01-04
    Brentuximab Vedotin (Adcetris®) Coverage Criteriablue cross blue shield - tennessee2026-12-31
    Pemetrexed Coverageblue cross blue shield - tennessee2026-12-31
    Tumor Treatment Fields - Medical PolicyHealth-New-England2026-12-01
    Extracorporeal PhotopheresisCigna2026-11-15
    VonvendiCigna2026-11-15
    Hematology - AphexdaCigna2026-11-15
    Extracorporeal PhotopheresisCigna2026-11-15
    Yartemlea (narsoplimab-wuug) Coverage for TA-TMANeighborhood Health Plan of Rhode Island2026-11-01

    Related Codes

    CPT-38205-APHERESIS-HPC-PERIPHERAL-BLOOD-HARVEST

    CPT 38205: Apheresis Hematopoietic Progenitor Cell Harvest

    CPT-38206-AUTOLOGOUS-HPC-APHERESIS-COLLECTION

    CPT 38206: Autologous Hematopoietic Progenitor Cell Apheresis

    CPT-38207-HEMATOPOIETIC-PROGENITOR-CELL-PRESERVATION-STORAGE

    CPT 38207: Management of Hematopoietic Progenitor Cell Preservation

    CPT-38208-THAW-PREPARATION-HEMATOPOIETIC-PROGENITOR-CELLS

    CPT 38208: Thawing of Previously Frozen Hematopoietic Progenitor Cells

    CPT-38209-HPC-THAWING-AND-WASHING-FOR-TRANSPLANTATION

    CPT 38209: Thaw and Wash Hematopoietic Progenitor Cells for Transplant

    CPT-38210-T-CELL-DEPLETED-HEMATOPOIETIC-PROGENITOR-CELL-PREPARATION

    CPT 38210: T-Cell–Reduced Hematopoietic Progenitor Cell Preparation

    CPT-38211-HEMATOPOIETIC-PROGENITOR-CELL-TUMOR-REDUCTION-PROCESSING

    CPT 38211: Hematopoietic Progenitor Cell Enrichment and Tumor Depletion

    CPT-38212-HPC-RED-CELL-DEPLETION-PREPARATION

    CPT 38212: HPC Red Cell Depletion for Transplant Preparation

    CPT-38213-HPC-SOLUTION-PREPARATION-PLATELET-REDUCTION

    CPT 38213: Hematopoietic Progenitor Cell Preparation to Reduce Platelets

    CPT-38214-HPC-MINIMAL-PLASMA-VOLUME-PREPARATION

    CPT 38214: Preparation of HPCs to Minimal Plasma Volume

    Showing 1–10 of 20

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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