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    v1.0.28
    OpenPayerBilling CodesMalignant neoplasms of mesothelial and soft tissueICD-10-CM c49-malignant-neoplasm-of-soft-tissue
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    ICD-10-CM Code For Malignant Neoplasm Of Other Connective And Soft Tissue: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C49 includes malignant neoplasms of other connective and soft tissues, covering sarcomas and related malignancies arising in fat, muscle, peripheral nerves, blood vessels, and other soft tissues. These ICD-10-CM diagnosis codes are used to document primary tumor site, laterality when applicable, and involvement of adjacent structures, capturing disease severity, organ involvement, or clinical complexity relevant to this group. Accurate coding within the ICD-10-CM C49 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM C49: Malignant Neoplasm Of Other Connective And Soft Tissue Overview

    The malignant neoplasms in this group represent cancers arising from connective and soft tissues such as fat, muscle, fibrous tissue, peripheral nerves, and blood vessels. These tumors can occur throughout the body and may affect local structures, function, and metastatic potential. Accurate coding captures the specific site and extent of disease and supports appropriate reimbursement and longitudinal clinical tracking.

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    When to Use

    Use codes from this group when documentation identifies a primary malignant tumor arising from connective or soft tissue structures and specifies the anatomic site. Apply the most specific code available to reflect laterality and involved subsite when reported in the clinical record.

    ICD-10-CM Codes

    20 rows

    ICD-10-CM CodeDescription
    C49.0Malignant neoplasm of connective and soft tissue of head, face and neck
    C49.10Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder
    C49.11Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder
    C49.12Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder
    C49.20Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip
    C49.21Malignant neoplasm of connective and soft tissue of right lower limb, including hip
    C49.22Malignant neoplasm of connective and soft tissue of left lower limb, including hip
    C49.3Malignant neoplasm of connective and soft tissue of thorax
    C49.4Malignant neoplasm of connective and soft tissue of abdomen
    C49.5Malignant neoplasm of connective and soft tissue of pelvis
    C49.6Malignant neoplasm of connective and soft tissue of trunk, unspecified
    C49.8Malignant neoplasm of overlapping sites of connective and soft tissue
    C49.9Malignant neoplasm of connective and soft tissue, unspecified
    C49.A0Gastrointestinal stromal tumor, unspecified site
    C49.A1Gastrointestinal stromal tumor of esophagus
    C49.A2Gastrointestinal stromal tumor of stomach
    C49.A3Gastrointestinal stromal tumor of small intestine
    C49.A4Gastrointestinal stromal tumor of large intestine
    C49.A5Gastrointestinal stromal tumor of rectum
    C49.A9Gastrointestinal stromal tumor of other sites

    DRG Codes

    6 rows

    DRG CodeDescription
    374Digestive Malignancy with MCC
    375Digestive Malignancy with CC
    376Digestive Malignancy without CC/MCC
    542Pathological Fractures and Musculoskeletal and Connective Tissue Malignancy with MCC
    543Pathological Fractures and Musculoskeletal and Connective Tissue Malignancy with CC
    544Pathological Fractures and Musculoskeletal and Connective Tissue Malignancy without CC/MCC

    Typical Clinical Scenarios

    • An adult presents to the oncology clinic with a slowly enlarging, painless mass deep in the thigh that has progressively increased over several months; imaging shows a large intramuscular soft tissue tumor without distant metastasis and biopsy confirms a malignant spindle-cell sarcoma of the connective tissue. The patient is referred for staging and treatment planning for a primary malignant soft tissue neoplasm of the lower limb, and a location-specific code from this group is assigned to document the primary tumor site. Typical codes: C49.1, C49.12
    • An elderly patient arrives to the emergency department with acute onset abdominal pain and abdominal distention; CT reveals a large retroperitoneal soft tissue mass causing bowel obstruction and possible local invasion, and biopsy demonstrates a high-grade malignant soft tissue tumor of the retroperitoneum. Because the presentation is acute with obstructive complications and the neoplasm arises in the retroperitoneal connective tissue, a code from this group identifying the retroperitoneal site is used for urgent diagnosis and hospital coding. Typical codes: C49.3, C49.9
    • A middle-aged patient with a known history of a previously resected malignant soft tissue tumor of the upper arm presents for surveillance after adjuvant therapy; follow-up MRI shows a suspicious recurrent lesion at the surgical bed, and pathology confirms local recurrence of the connective tissue malignancy. For longitudinal care and recurrence management, a site-specific code from this group is recorded to document recurrent or persistent disease at the upper limb/shoulder region. Typical codes: C49.0, C49.02

    Related Codes

    C45-MESOTHELIOMA

    ICD-10-CM Code For Mesothelioma: Group Overview

    C46-KAPOSIS-SARCOMA

    ICD-10-CM Code For Kaposi's Sarcoma: Group Overview

    C47-MALIGNANT-NEOPLASM-PERIPHERAL-NERVES

    ICD-10-CM Code For Malignant Neoplasm Of Peripheral Nerves And Autonomic Nervous System: Group Overview

    C48-MALIGNANT-NEOPLASM-RETROPERITONEUM-PERITONEUM

    ICD-10-CM Code For Malignant Neoplasm Of Retroperitoneum And Peritoneum: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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