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    OpenPayerBilling CodesMalignant neoplasms of mesothelial and soft tissueICD-10-CM c47-malignant-neoplasm-peripheral-nerves
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    ICD-10-CM Code For Malignant Neoplasm Of Peripheral Nerves And Autonomic Nervous System: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C47 includes malignant neoplasms of peripheral nerves and the autonomic nervous system, covering primary cancers originating in peripheral nerve sheaths and related soft tissue structures. These ICD-10-CM diagnosis codes are used to document clinical encounters for malignancies that involve nerve roots, plexuses, or peripheral nerve trunks, capturing tumor site, laterality, and extent when applicable. Accurate coding within the ICD-10-CM C47 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM C47: Malignant Neoplasm Of Peripheral Nerves And Autonomic Nervous System Overview

    This group represents malignant tumors arising from peripheral nerves and the autonomic nervous system, including schwannomas and neurofibrosarcomas that have undergone malignant transformation. These neoplasms affect the peripheral nervous system and adjacent soft tissues and can cause pain, neurologic deficits, or mass effect depending on location. Accurate coding is essential for complete clinical documentation and supports appropriate reimbursement for oncology and surgical services.

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    When to Use

    Use a code from this group when a confirmed malignant neoplasm is documented as arising from peripheral nerves or autonomic nerve structures. Apply the most specific code available that reflects site, laterality, and any documented extension or recurrence.

    ICD-10-CM Codes

    13 rows

    ICD-10-CM CodeDescription
    C47.0Malignant neoplasm of peripheral nerves of head, face and neck
    C47.10Malignant neoplasm of peripheral nerves of unspecified upper limb, including shoulder
    C47.11Malignant neoplasm of peripheral nerves of right upper limb, including shoulder
    C47.12Malignant neoplasm of peripheral nerves of left upper limb, including shoulder
    C47.20Malignant neoplasm of peripheral nerves of unspecified lower limb, including hip
    C47.21Malignant neoplasm of peripheral nerves of right lower limb, including hip
    C47.22Malignant neoplasm of peripheral nerves of left lower limb, including hip
    C47.3Malignant neoplasm of peripheral nerves of thorax
    C47.4Malignant neoplasm of peripheral nerves of abdomen
    C47.5Malignant neoplasm of peripheral nerves of pelvis
    C47.6Malignant neoplasm of peripheral nerves of trunk, unspecified
    C47.8Malignant neoplasm of overlapping sites of peripheral nerves and autonomic nervous system
    C47.9Malignant neoplasm of peripheral nerves and autonomic nervous system, unspecified

    DRG Codes

    3 rows

    DRG CodeDescription
    542Pathological Fractures and Musculoskeletal and Connective Tissue Malignancy with MCC
    543Pathological Fractures and Musculoskeletal and Connective Tissue Malignancy with CC
    544Pathological Fractures and Musculoskeletal and Connective Tissue Malignancy without CC/MCC

    Typical Clinical Scenarios

    • An adult in their 50s presents to the neurosurgery clinic with several months of progressive, localized numbness, paresthesia, and a palpable enlarging, painful mass along the course of the sciatic nerve in the posterior thigh. Imaging (MRI) demonstrates a well-defined enhancing soft-tissue mass centered on the sciatic nerve consistent with a malignant peripheral nerve sheath tumor; biopsy confirms malignancy. A code from this group is assigned to capture the primary malignant neoplasm of that peripheral nerve location. Typical codes: C47.2, C47.21.
    • An elderly patient is admitted from the emergency department with acute onset severe hoarseness, dysphagia, and shoulder weakness after a rapidly enlarging neck mass; imaging reveals an infiltrative malignant tumor involving the brachial plexus and adjacent cervical peripheral nerves. Hospitalization is for diagnostic workup and initiation of oncologic and supportive care for a malignant neoplasm involving peripheral nerves of the neck/shoulder region, so a site-specific malignant nerve neoplasm code is used. Typical codes: C47.0, C47.11.
    • A middle-aged patient with a history of previously treated extremity sarcoma now in surveillance presents with new neuropathic pain and motor deficit in the hand; PET/CT identifies a recurrent malignant tumor along the ulnar nerve in the forearm, with concern for local recurrence rather than metastatic disease. The encounter documents a recurrent or persistent malignant peripheral nerve tumor at a specific limb site, prompting assignment of a code that specifies the nerve region of the upper limb. Typical codes: C47.4, C47.11.

    Related Codes

    C45-MESOTHELIOMA

    ICD-10-CM Code For Mesothelioma: Group Overview

    C46-KAPOSIS-SARCOMA

    ICD-10-CM Code For Kaposi's Sarcoma: Group Overview

    C48-MALIGNANT-NEOPLASM-RETROPERITONEUM-PERITONEUM

    ICD-10-CM Code For Malignant Neoplasm Of Retroperitoneum And Peritoneum: Group Overview

    C49-MALIGNANT-NEOPLASM-OF-SOFT-TISSUE

    ICD-10-CM Code For Malignant Neoplasm Of Other Connective And Soft Tissue: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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