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    v1.0.28
    OpenPayerBilling CodesMalignant neoplasms of mesothelial and soft tissueICD-10-CM c45-mesothelioma
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    ICD-10-CM Code For Mesothelioma: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C45 includes malignant mesotheliomas of the pleura, peritoneum, pericardium, tunica vaginalis, and unspecified sites, covering primary cancers of mesothelial tissues. These ICD-10-CM diagnosis codes are used to document primary malignant mesothelial neoplasms, capturing site of origin, laterality when applicable, and extent of disease for clinical and administrative records. Accurate coding within the ICD-10-CM C45 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM C45: Mesothelioma Overview

    The ICD-10-CM C45 group represents malignant neoplasms arising from mesothelial tissues, most commonly involving the pleura, peritoneum, pericardium, or tunica vaginalis. These diagnoses target cancers originating in the mesothelial lining of body cavities and adjacent soft tissues. Accurate coding is important for appropriate claim adjudication, epidemiology, and reimbursement for cancer-directed care.

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    When to Use

    Use a code from this group when a clinician documents a diagnosis of malignant mesothelioma with specification of site or when pathology confirms a mesothelial primary malignancy. Choose the most specific code available to reflect the documented site and any laterality or extension noted in the clinical record.

    ICD-10-CM Codes

    5 rows

    ICD-10-CM CodeDescription
    C45.0Mesothelioma of pleura
    C45.1Mesothelioma of peritoneum
    C45.2Mesothelioma of pericardium
    C45.7Mesothelioma of other sites
    C45.9Mesothelioma, unspecified

    DRG Codes

    17 rows

    DRG CodeDescription
    180Respiratory Neoplasms with MCC
    181Respiratory Neoplasms with CC
    182Respiratory Neoplasms without CC/MCC
    314Other Circulatory System Diagnoses with MCC
    315Other Circulatory System Diagnoses with CC
    316Other Circulatory System Diagnoses without CC/MCC
    374Digestive Malignancy with MCC
    375Digestive Malignancy with CC
    376Digestive Malignancy without CC/MCC
    826Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with MCC
    827Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with CC
    828Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures without CC/MCC
    829Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures with CC/MCC
    830Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures without CC/MCC
    843Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses with MCC
    844Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses with CC
    845Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses without CC/MCC

    Typical Clinical Scenarios

    • An elderly construction worker with progressive dyspnea, pleuritic chest pain, and unintentional weight loss presents after imaging shows a unilateral pleural effusion with nodular pleural thickening and pleural biopsy confirming malignant mesothelial tumor localized to the pleura; this is an initial diagnosis of primary pleural mesothelioma established by histopathology, so a pleural mesothelioma code is assigned. Typical codes: C45.0
    • A middle-aged patient with a history of peritoneal dialysis who has chronic abdominal distension, pain, and imaging demonstrating diffuse peritoneal masses; tissue biopsy confirms malignant mesothelioma of the peritoneum, representing a chronic, ongoing primary intra-abdominal malignancy requiring coding for peritoneal mesothelioma. Typical codes: C45.1
    • A patient with known malignant mesothelioma presents acutely with obstructive symptoms from a retroperitoneal mass causing ureteral compression and hydronephrosis; the visit documents a mesothelioma-related complication arising from soft tissue involvement, and coding reflects malignant mesothelioma of other specified sites or unspecified mesothelial sites when site detail is limited. Typical codes: C45.2, C45.9

    Related Codes

    C46-KAPOSIS-SARCOMA

    ICD-10-CM Code For Kaposi's Sarcoma: Group Overview

    C47-MALIGNANT-NEOPLASM-PERIPHERAL-NERVES

    ICD-10-CM Code For Malignant Neoplasm Of Peripheral Nerves And Autonomic Nervous System: Group Overview

    C48-MALIGNANT-NEOPLASM-RETROPERITONEUM-PERITONEUM

    ICD-10-CM Code For Malignant Neoplasm Of Retroperitoneum And Peritoneum: Group Overview

    C49-MALIGNANT-NEOPLASM-OF-SOFT-TISSUE

    ICD-10-CM Code For Malignant Neoplasm Of Other Connective And Soft Tissue: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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