ICD-10-CM Code For Herpesviral Herpes Simplex Infections: Group Overview

The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group B00 includes herpesviral infections such as herpes simplex presenting as orolabial, genital, neonatal, or disseminated disease and related complications like herpes zoster-associated conditions. These ICD-10-CM diagnosis codes are used to document acute versus recurrent presentations, specify affected anatomical sites, and capture complications or systemic involvement relevant to these viral infections. Accurate coding within the ICD-10-CM B00 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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ICD-10-CM B00: Herpesviral [herpes simplex] Infections Overview

This group includes herpesviral infections caused primarily by herpes simplex viruses that produce skin and mucous membrane lesions. It targets dermatologic and mucosal infections such as orolabial, genital, and disseminated herpes affecting multiple organ systems. Accurate coding matters for reimbursement because it captures disease site, complications, and severity which influence claim adjudication and payment.

When to Use

Use a code from this group when documenting confirmed or suspected herpes simplex viral infection with specification of site, episode type, or complications to accurately reflect clinical status. Codes are selected based on the anatomical location, whether the episode is initial or recurrent, and the presence of systemic involvement or neonatal disease.

ICD-10-CM Codes

15 rows

ICD-10-CM Code	Description
B00.0	Eczema herpeticum
B00.1	Herpesviral vesicular dermatitis
B00.2	Herpesviral gingivostomatitis and pharyngotonsillitis
B00.3	Herpesviral meningitis
B00.4	Herpesviral encephalitis
B00.50	Herpesviral ocular disease, unspecified
B00.51	Herpesviral iridocyclitis
B00.52	Herpesviral keratitis
B00.53	Herpesviral conjunctivitis
B00.59	Other herpesviral disease of eye
B00.7	Disseminated herpesviral disease
B00.81	Herpesviral hepatitis
B00.82	Herpes simplex myelitis
B00.89	Other herpesviral infection
B00.9	Herpesviral infection, unspecified

DRG Codes

33 rows

DRG Code	Description
011	Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with MCC
012	Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with CC
013	Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy without CC/MCC
023	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis with MCC or Antineoplastic Implant or Epilepsy with Neurostimulator
024	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis without MCC
075	Viral Meningitis with CC/MCC
076	Viral Meningitis without CC/MCC
097	Non-Bacterial Infection of Nervous System Except Viral Meningitis with MCC
098	Non-Bacterial Infection of Nervous System Except Viral Meningitis with CC
099	Non-Bacterial Infection of Nervous System Except Viral Meningitis without CC/MCC
124	Other Disorders of the Eye with MCC or Thrombolytic Agent
125	Other Disorders of the Eye without MCC
154	Other Ear, Nose, Mouth and Throat Diagnoses with MCC
155	Other Ear, Nose, Mouth and Throat Diagnoses with CC
156	Other Ear, Nose, Mouth and Throat Diagnoses without CC/MCC
157	Dental and Oral Diseases with MCC
158	Dental and Oral Diseases with CC
159	Dental and Oral Diseases without CC/MCC
393	Other Digestive System Diagnoses with MCC
394	Other Digestive System Diagnoses with CC

Showing 1–20 of 33

Typical Clinical Scenarios

An adult presents to the emergency department with multiple painful, grouped vesicles and erosions on the lower lip and perioral skin after prodromal tingling and fever; physical exam shows active ulcerative lesions and the patient reports difficulty eating. This is an acute mucocutaneous outbreak attributable to herpes simplex virus, prompting an acute herpesviral diagnosis for antiviral therapy and infection control. Typical codes: B00.1, B00.0
A woman with a history of genital herpes experiences recurrent, localized vulvar pain and shallow ulcers occurring several times per year; she seeks outpatient care for episodic management and documentation of recurrent disease without systemic symptoms. Because this is a recurrent mucosal infection due to herpes simplex, a code for recurrent genital herpes is assigned for outpatient treatment and follow-up care. Typical codes: B00.2, B00.9
A neonate is admitted from the nursery with lethargy, temperature instability, and seizures after developing disseminated vesicular lesions; workup confirms systemic involvement of herpesvirus with CNS symptoms, requiring intensive care and antiviral therapy. This represents a severe complication of neonatal herpes infection and is coded to capture systemic and CNS involvement. Typical codes: B00.50, B00.51

Related Codes

B01-VARICELLA-CHICKENPOX

ICD-10-CM Code For Varicella Chickenpox: Group Overview

B02-ZOSTER-HERPES-ZOSTER

ICD-10-CM Code For Zoster Herpes Zoster: Group Overview

B03-SMALLPOX

ICD-10-CM Code For Smallpox: Group Overview

B04-MONKEYPOX

ICD-10-CM Code For Monkeypox: Group Overview

B05-MEASLES

ICD-10-CM Code For Measles: Group Overview

B06-RUBELLA-GERMAN-MEASLES

ICD-10-CM Code For Rubella German Measles: Group Overview

B07-VIRAL-WARTS

ICD-10-CM Code For Viral Warts: Group Overview

B08-OTHER-VIRAL-SKIN-AND-MUCOUS-LESIONS

ICD-10-CM Code For Other Viral Infections Characterized By Skin And Mucous Membrane Lesions: Group Overview

B09-UNSPECIFIED-VIRAL-MUCOCUTANEOUS-LESIONS

ICD-10-CM Code For Unspecified Viral Infection Characterized By Skin And Mucous Membrane Lesions: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-CM Codes

15 rows

ICD-10-CM Code	Description
B00.0	Eczema herpeticum
B00.1	Herpesviral vesicular dermatitis
B00.2	Herpesviral gingivostomatitis and pharyngotonsillitis
B00.3	Herpesviral meningitis
B00.4	Herpesviral encephalitis
B00.50	Herpesviral ocular disease, unspecified
B00.51	Herpesviral iridocyclitis
B00.52	Herpesviral keratitis
B00.53	Herpesviral conjunctivitis
B00.59	Other herpesviral disease of eye
B00.7	Disseminated herpesviral disease
B00.81	Herpesviral hepatitis
B00.82	Herpes simplex myelitis
B00.89	Other herpesviral infection
B00.9	Herpesviral infection, unspecified

DRG Codes

33 rows

DRG Code	Description
011	Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with MCC
012	Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with CC
013	Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy without CC/MCC
023	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis with MCC or Antineoplastic Implant or Epilepsy with Neurostimulator
024	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis without MCC
075	Viral Meningitis with CC/MCC
076	Viral Meningitis without CC/MCC
097	Non-Bacterial Infection of Nervous System Except Viral Meningitis with MCC
098	Non-Bacterial Infection of Nervous System Except Viral Meningitis with CC
099	Non-Bacterial Infection of Nervous System Except Viral Meningitis without CC/MCC
124	Other Disorders of the Eye with MCC or Thrombolytic Agent
125	Other Disorders of the Eye without MCC
154	Other Ear, Nose, Mouth and Throat Diagnoses with MCC
155	Other Ear, Nose, Mouth and Throat Diagnoses with CC
156	Other Ear, Nose, Mouth and Throat Diagnoses without CC/MCC
157	Dental and Oral Diseases with MCC
158	Dental and Oral Diseases with CC
159	Dental and Oral Diseases without CC/MCC
393	Other Digestive System Diagnoses with MCC
394	Other Digestive System Diagnoses with CC

Showing 1–20 of 33

Typical Clinical Scenarios

An adult presents to the emergency department with multiple painful, grouped vesicles and erosions on the lower lip and perioral skin after prodromal tingling and fever; physical exam shows active ulcerative lesions and the patient reports difficulty eating. This is an acute mucocutaneous outbreak attributable to herpes simplex virus, prompting an acute herpesviral diagnosis for antiviral therapy and infection control. Typical codes: B00.1, B00.0
A woman with a history of genital herpes experiences recurrent, localized vulvar pain and shallow ulcers occurring several times per year; she seeks outpatient care for episodic management and documentation of recurrent disease without systemic symptoms. Because this is a recurrent mucosal infection due to herpes simplex, a code for recurrent genital herpes is assigned for outpatient treatment and follow-up care. Typical codes: B00.2, B00.9
A neonate is admitted from the nursery with lethargy, temperature instability, and seizures after developing disseminated vesicular lesions; workup confirms systemic involvement of herpesvirus with CNS symptoms, requiring intensive care and antiviral therapy. This represents a severe complication of neonatal herpes infection and is coded to capture systemic and CNS involvement. Typical codes: B00.50, B00.51

Related Codes

B01-VARICELLA-CHICKENPOX

ICD-10-CM Code For Varicella Chickenpox: Group Overview

B02-ZOSTER-HERPES-ZOSTER

ICD-10-CM Code For Zoster Herpes Zoster: Group Overview

B03-SMALLPOX

ICD-10-CM Code For Smallpox: Group Overview

B04-MONKEYPOX

ICD-10-CM Code For Monkeypox: Group Overview

B05-MEASLES

ICD-10-CM Code For Measles: Group Overview

B06-RUBELLA-GERMAN-MEASLES

ICD-10-CM Code For Rubella German Measles: Group Overview

B07-VIRAL-WARTS

ICD-10-CM Code For Viral Warts: Group Overview

B08-OTHER-VIRAL-SKIN-AND-MUCOUS-LESIONS

ICD-10-CM Code For Other Viral Infections Characterized By Skin And Mucous Membrane Lesions: Group Overview

B09-UNSPECIFIED-VIRAL-MUCOCUTANEOUS-LESIONS

ICD-10-CM Code For Unspecified Viral Infection Characterized By Skin And Mucous Membrane Lesions: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-CM Code For Herpesviral Herpes Simplex Infections: Group Overview

Sign up for ICD-10-CM Code For Herpesviral Herpes Simplex Infections: Group Overview policy alerts

ICD-10-CM B00: Herpesviral [herpes simplex] Infections Overview

ICD-10-CM Code For Herpesviral Herpes Simplex Infections: Group Overview

Sign up for ICD-10-CM Code For Herpesviral Herpes Simplex Infections: Group Overview policy alerts

ICD-10-CM B00: Herpesviral [herpes simplex] Infections Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-CM codes are included in the B00 group for herpesviral infections?

How does accurate coding within the `B00` group affect reimbursement?

Which `B00` codes indicate central nervous system involvement?

Are there `B00` codes for ocular herpesviral disease and how are they specified?

What related DRGs might be relevant when coding a principal diagnosis from the `B00` group?

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-CM codes are included in the B00 group for herpesviral infections?

How does accurate coding within the `B00` group affect reimbursement?

Which `B00` codes indicate central nervous system involvement?

Are there `B00` codes for ocular herpesviral disease and how are they specified?

What related DRGs might be relevant when coding a principal diagnosis from the `B00` group?

References