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    v1.0.28
    OpenPayerBilling CodesViral infections characterized by skin and mucous membrane lesionsICD-10-CM b03-smallpox
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    ICD-10-CM Code For Smallpox: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group B03 includes diagnoses for smallpox and its clinical variants, covering presentations from variola major to variola minor with associated cutaneous and systemic manifestations. These ICD-10-CM diagnosis codes are used to document acute viral infection with characteristic skin and mucous membrane lesions, capture disease severity, and note complications or systemic involvement. Accurate coding within the ICD-10-CM B03 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM B03: Smallpox Overview

    The ICD-10-CM B03 code group represents smallpox diagnoses, a viral infection characterized by widespread skin and mucous membrane lesions caused by variola virus. These conditions primarily affect the integumentary system and can involve systemic illness with fever and systemic complications. Accurate coding matters for reimbursement because it ensures clinical encounters and resource use related to severe infectious disease management are documented precisely.

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    When to Use

    Use a code from this group when a clinical diagnosis of smallpox or a specified variola virus infection is documented by a qualified clinician. Codes are applied to record the presence of characteristic skin and mucous membrane lesions, systemic symptoms, and any documented complications that affect clinical management or resource use.

    ICD-10-CM Codes

    1 rows

    ICD-10-CM CodeDescription
    B03Smallpox

    DRG Codes

    2 rows

    DRG CodeDescription
    865Viral Illness with MCC
    866Viral Illness without MCC

    Typical Clinical Scenarios

    • An adult presents to the emergency department with sudden onset high fever, severe malaise, and a diffuse vesicular-pustular rash involving the face, trunk, and extremities; lesions are synchronous in development and progress from macules to pustules. The patient reports recent close contact with a person known to have an orthopoxvirus infection, and emergency clinicians isolate the patient and obtain samples for confirmatory testing. A diagnosis from this group is assigned due to the classic systemic febrile illness with characteristic skin lesions consistent with smallpox. Typical codes: B03
    • A newborn in the neonatal unit is evaluated for widespread vesiculopustular lesions noted at birth, with maternal history revealing recent febrile illness late in pregnancy; the neonate has fever and poor feeding. Infectious disease and neonatology teams initiate diagnostic testing and supportive care while considering perinatal transmission possibilities. A code from this group is assigned when clinical findings and exposure history suggest congenital or perinatally acquired smallpox infection. Typical codes: B03
    • An inpatient with multi-organ complications develops secondary bacterial pneumonia and septic shock following an acute febrile vesicular rash illness that required prior isolation; the patient’s clinical course is prolonged and includes wound care for ruptured skin lesions. The treating team documents the original viral skin infection as the underlying cause precipitating complications and coordinates coding for the viral etiology alongside the complications. Typical codes: B03

    Related Codes

    B00-HERPESVIRAL-HERPES-SIMPLEX-INFECTIONS

    ICD-10-CM Code For Herpesviral Herpes Simplex Infections: Group Overview

    B01-VARICELLA-CHICKENPOX

    ICD-10-CM Code For Varicella Chickenpox: Group Overview

    B02-ZOSTER-HERPES-ZOSTER

    ICD-10-CM Code For Zoster Herpes Zoster: Group Overview

    B04-MONKEYPOX

    ICD-10-CM Code For Monkeypox: Group Overview

    B05-MEASLES

    ICD-10-CM Code For Measles: Group Overview

    B06-RUBELLA-GERMAN-MEASLES

    ICD-10-CM Code For Rubella German Measles: Group Overview

    B07-VIRAL-WARTS

    ICD-10-CM Code For Viral Warts: Group Overview

    B08-OTHER-VIRAL-SKIN-AND-MUCOUS-LESIONS

    ICD-10-CM Code For Other Viral Infections Characterized By Skin And Mucous Membrane Lesions: Group Overview

    B09-UNSPECIFIED-VIRAL-MUCOCUTANEOUS-LESIONS

    ICD-10-CM Code For Unspecified Viral Infection Characterized By Skin And Mucous Membrane Lesions: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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