Infertility, Fertility Preservation, Assisted Reproductive Technology
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Defines medical necessity, coverage stance, and required prior authorization for infertility evaluation, fertility preservation for iatrogenic infertility (notably cancer-related), and associated assisted reproductive technology services for members of Baylor Scott & White Health Plan.
No material clinical or coverage changes in this revision.
Coverage Criteria
Iatrogenic Fertility Preservation (Cancer-related)
BSWHP may consider Fertility Preservation services medically necessary when ALL of the following are met:
Diagnostic Evaluation of Infertility
BSWHP may consider infertility and reproductive technology medically necessary for diagnostic evaluation when performed stepwise:
Scoped covered services (code-based)
Covered services and relevant diagnoses are identified by listed HCPCS and ICD-10 codes.
Full clinical medical necessity prerequisites are specified elsewhere in the policy (see Iatrogenic Fertility Preservation and Diagnostic Evaluation sections).
Most Baylor Scott & White Health Plan members have coverage for the diagnostic evaluation of infertility but treatment of infertility is not a benefit for most plans unless specifically purchased as a rider. Where infertility treatment is a covered benefit under a plan, interventions are typically limited to in vitro fertilization (IVF). Prior authorization is required for fertility preservation services, and fertility preservation and storage of reproductive material may not be a benefit for some plans; when covered, services may be limited to standard retrieval, isolation, and cryopreservation. Hormonal therapies/medications and storage of unfertilized genetic materials may be excluded depending on the member's benefit document.
The excerpt reviewed does not contain a separate, fully detailed exclusions section within these chunks. The policy history notes prior updates (including corrected exclusions and clarifications added in 2024–2025) but the specific exclusion language beyond the summary that treatment is not a benefit for most plans appears only in the plan-level Evidence of Coverage (EOC) or SPD; reviewers should refer to those member-specific documents for the definitive exclusion and limitation text.
Policies referencing state or legislative requirements and prior revisions are documented in the policy update log; any plan-level application of exclusions or riders should be confirmed against the applicable EOC/SPD and the policy change history.
The policy identifies a number of services that BSWHP considers experimental, investigational, or unproven for the treatment or evaluation of infertility. Examples listed include: acupuncture; hyperbaric oxygen therapy for IVF; intravaginal culture devices (e.g., INVOcell); various immune treatments (peri-implantation glucocorticoids, anti‑TNF agents, leukocyte immunization, IVIG); computer-assisted sperm motion analysis; co‑culture techniques for embryo/oocyte culture; direct intraperitoneal or intrafollicular insemination; endometrial receptivity testing (e.g., Endometrial Function Test™, ERA); fine needle aspiration mapping; hemizona test; hyaluronan binding assay; sperm viability tests when used diagnostically; use of sperm precursors; manual soft tissue therapies for pelvic adhesions; laser removal of necrotic blastomeres from cryopreserved embryos; reactive oxygen species testing; time-lapse embryo imaging (e.g., EmbryoScope); uterine transplantation; vaginal microbiome testing; and saline-air infused sono-hysterosalpingogram variants (e.g., femVue®).
Within the provided excerpt there are no explicit statements formatted as ‘not medically necessary’ for specific services beyond the list of experimental or investigational items. The policy change log indicates prior revisions and corrections to exclusions, suggesting editorial updates have been made in earlier versions, but the reviewed chunks do not include separate, formalized 'not medically necessary' language; determination of not medically necessary should follow the policy criteria and member plan benefits.
Coding and Billing Codes
| 54500 | Biopsy of testis, needle (separate procedure) |
| 54505 | Biopsy of testis, incisional (separate procedure) |
| 54800 | Biopsy of epididymis, needle |
| 55200 | Vasotomy, cannulization with or without incision of vas, unilateral or bilateral (separate procedure) |
| 55870 | Electroejaculation* |
| 58970 | Follicle Puncture for Oocyte retrieval, any Method (IVF)* |
| 58974 | Embryo transfer, intrauterine |
| 58976 | Gamete, zygote, or embryo intrafallopian transfer, any method |
| 76948 | Ultrasonic guidance for aspiration of ova, imaging supervision and interpretation* |
| 83001 | Gonadotropin; follicle stimulating hormone (FSH) |
| 89337 | Cryopreservation, mature oocyte(s)* |
| 89342 | Storage, (per year) for embryo(s) |
| 89344 | Storage, (per year) for reproductive tissue, testicular/ovarian |
| 89346 | Storage, (per year) for oocyte(s) |
| 89352 | Thawing of cryopreserved; embryo(s) |
| 89353 | Thawing of cryopreserved; sperm/semen, each aliquot |
| 89354 | Thawing of cryopreserved; reproductive tissue, testicular/ovarian |
| 0058T | Cryopreservation; reproductive tissue, ovarian* |
| G0027 | Semen analysis; presence and/or motility of sperm excluding Huhner |
| J0725 | Injection, chorionic gonadotropin, per 1,000 USP units |
| J3355 | Injection, urofollitropin, 75 IU |
| Q0115 | Postcoital direct, qualitative examinations of vaginal or cervical mucous |
| S0122 | Injection, menotropins, 75 IU |
| S0126 | Injection, follitropin alfa, 75 IU |
| S0128 | Injection, follitropin beta, 75 IU |
| S0132 | Injection, ganirelix acetate, 250 mcg |
| S4011 | In vitro fertilization; including but not limited to identification and incubation of mature oocytes, fertilization with sperm, incubation of embryo(s), and subsequent visualization for determination of development |
| N46.01 | Organic azoospermia |
| N46.021 | Azoospermia due to drug therapy |
| N46.022 | Azoospermia due to infection |
| N46.023 | Azoospermia due to obstruction of efferent ducts |
| N46.024 | Azoospermia due to radiation |
| N46.025 | Azoospermia due to systemic disease |
| N46.029 | Azoospermia due to other extratesticular causes |
| N46.11 | Organic oligospermia |
| N46.121 | Oligospermia due to drug therapy |
| N46.122 | Oligospermia due to infection |
| S4022 | Assisted oocyte fertilization, case rate |
| S4023 | Donor egg cycle, incomplete, case rate |
| S4025 | Donor services for in vitro fertilization (sperm or embryo), case rate |
| S4026 | Procurement of donor sperm from sperm bank |
| S4027 | Storage of previously frozen embryos |
| S4028 | Microsurgical epididymal sperm aspiration (MESA) |
| S4030 | Sperm procurement and cryopreservation services; initial visit |
| S4031 | Sperm procurement and cryopreservation services; subsequent visit |
| S4035 | Stimulated intrauterine insemination (IUI), case rate |
| S4037 | Cryopreserved embryo transfer, case rate |
| E23.0- | Hypopituitarism (ICD10 example listed) |
| N46.01 | Organic azoospermia |
| N46.021 | Azoospermia due to drug therapy |
| N46.022 | Azoospermia due to infection |
| N46.023 | Azoospermia due to obstruction of efferent ducts |
| N46.024 | Azoospermia due to radiation |
| N46.025 | Azoospermia due to systemic disease |
| N46.029 | Azoospermia due to other extratesticular causes |
| N46.11 | Organic oligospermia |
| N46.121 | Oligospermia due to drug therapy |
Provider Actions and Authorization Requirements
Prior Authorization Required
Prior authorization is required for fertility preservation services. Failure to obtain prior authorization for these services may result in claim denial. Genetic/genomic testing may also require prior authorization.
- Prior authorization required for fertility preservation services (including iatrogenic fertility preservation).
- Genetic / genomic testing may require prior authorization.
Stepwise Diagnostic Evaluation
Evaluation for infertility is expected to be performed in a stepwise fashion based on patient history and prior test results; not all tests are necessary for every individual. Testing and diagnostic procedures should follow the clinical pathway appropriate to the presenting history.
- Stepwise diagnostic evaluation — order tests based on history and prior results; avoid reflexive full-panel testing for every patient.
- Male evaluation examples: history and physical exam; semen analysis (volume, concentration, motility, pH, fructose, leukocyte count, microbiology, morphology); endocrine testing (FSH, total and free testosterone, prolactin, LH, TSH); transrectal/scrotal ultrasound; vasography/testicular biopsy when indicated.
- Female evaluation examples: history and physical exam; laboratory tests (TSH, prolactin, FSH, LH, estradiol, progesterone); pelvic ultrasound; hysteroscopy; hysterosalpingography; sonohysterography; diagnostic laparoscopy with or without chromotubation.
Iatrogenic Fertility Preservation Documentation and Coding
Requests for iatrogenic fertility preservation must include the diagnosis code Z31.84 (Encounter for fertility preservation procedure) and supporting clinical documentation demonstrating the member has a diagnosis (e.g., cancer) and planned treatment that places them at risk for impaired fertility (chemotherapy, radiotherapy, or surgery). Documentation should also support the specific procedure(s) being requested and the applicable procedure/ICD-10 codes billed.
- Submit requests with ICD-10 code Z31.84 when for fertility preservation related to planned medical treatment.
- Include supporting documentation: cancer diagnosis, planned treatment details (e.g., chemo regimen, radiation fields/dose, planned surgery) and rationale linking treatment to risk of impaired fertility.
- Documentation must support use of listed S4xxx case-rate codes and related procurement, storage, donor, and microsurgical service codes; claims may be denied if billed with codes not listed or outside covered services.
Definitions
Background
Infertility is defined here as the inability to conceive or carry a pregnancy to live birth after a period of unprotected intercourse without contraception — specifically 12 months for individuals under age 35 or 6 months for those aged 35 or older. Causes of infertility include male factor, ovulation disorders, tubal damage, endometriosis, cervical or coital factors, and unexplained infertility. Evaluation typically follows a stepwise approach based on history and prior results and may include history and physical, targeted laboratory testing (TSH, prolactin, FSH, LH, estradiol, progesterone), pelvic ultrasound, hysterosalpingography, sonohysterography, hysteroscopy, diagnostic laparoscopy, and male evaluation such as semen analysis and endocrine testing. Iatrogenic infertility refers to fertility loss caused by medical treatment (most commonly cancer therapy), and fertility preservation options (including cryopreservation) are considered when planned gonadotoxic therapy is anticipated.
Revision History
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