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    v1.0.30
    OpenPayerBilling CodesTemporary National Codes (Non-Medicare)HCPCS hcpcs-s0132-ganirelix-acetate-250-mcg-injection
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    HCPCS Level II S0132: Injection, ganirelix acetate, 250 mcg

    HCPCS Level II code S0132 represents a single injection of ganirelix acetate, 250 mcg, used as an injectable gonadotropin‑releasing hormone (GnRH) antagonist in assisted reproductive technology; the service is an injection/medication administration typically provided in an ambulatory infusion clinic, fertility clinic, or outpatient physician office setting for controlled ovarian stimulation protocols.

    For related coverage guidance, see recent payer policy updates: Medical Necessity Guidelines Non-Emergency Transportation, Non-Emergent Transportation Medical Policy, Non-Emergency Facility to Facility Transfers.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a reproductive-age woman undergoing controlled ovarian stimulation as part of assisted reproductive technology (ART) such as in vitro fertilization (IVF). Ganirelix acetate 250 mcg is administered by subcutaneous injection to prevent premature luteinizing hormone (LH) surge and ovulation during the follicular phase. The clinical workflow includes baseline monitoring (transvaginal ultrasound and serum estradiol), initiation of gonadotropin injections, serial monitoring visits, and then daily or alternate-day administration of S0132 beginning when lead follicles reach the clinic’s size threshold (commonly 12–14 mm) until the day of ovulation trigger. Typical site of service is an outpatient fertility clinic, ambulatory surgery center if combined with egg retrieval, or physician office for teaching and dispensing the injection. The patient receives education on subcutaneous self-injection technique, observes injection during a clinic visit if needed, and returns for ongoing monitoring and the eventual oocyte retrieval procedure.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    58321Transvaginal oocyte retrieval, any methodPerformed after ovarian stimulation and S0132 use; the procedure that obtains oocytes for IVF
    58970Follicular monitoring (ultrasound)Serial transvaginal ultrasounds used during stimulation to monitor response while S0132 is administered
    81025Urine pregnancy test, by reagent stripUsed post-transfer or follow-up; not during stimulation but part of the overall IVF workflow
    96372Therapeutic, prophylactic, or diagnostic injection (subcutaneous or intramuscular)May be used for billing injection administration when payer requires a CPT for administration services alongside S0132 billing
    99213Office or other outpatient visit, established patient, low to moderate complexityFollow-up visits for dose adjustment, counseling, and monitoring during the stimulation cycle

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207V00000X
    208D00000X
    363L00000X
    367A00000X
    363A00000X
    1835C0206X
    2255R0406X
    2251G0304X

    Related ICD-10-CM Codes

    21 rows

    ICD-10-CM CodeDescription
    E03.9Hypothyroidism, unspecified
    E16.0Drug-induced hypoglycemia without coma
    E23.0Hypopituitarism
    E28.2Polycystic ovarian syndrome
    E28.9Ovarian dysfunction, unspecified
    N91.1Secondary amenorrhea
    N91.2Amenorrhea, unspecified
    N97.0Female infertility associated with anovulation
    N97.1Female infertility of tubal origin
    N97.2Female infertility of uterine origin

    Showing 1–10 of 21

    Related Payer Policy Updates

    Specialty: Emergency & Medical Transportation1 / 3

    10 rows

    PolicyPayerEffective Date
    Medical Necessity Guidelines Non-Emergency TransportationMass General Brigham Health Plan2026-11-01
    Non-Emergent Transportation Medical PolicyHealth-New-England2026-11-01
    Non-Emergency Facility to Facility Transfershap_caresource_mi_coordinated_health2026-11-01
    Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policybcbsvermont2026-10-01
    Emergency Air/Water Ambulance Services Medical GuidelineWPS Health Insurance2026-10-01
    Non-Emergent Ambulance ServicesConnectiCare2026-09-11
    Fixed Wing Air Ambulance TransportCigna2026-08-15
    Air AmbulanceAmbetter Georgia2026-08-01
    Ambulance Services (for Tennessee Only)UnitedHealthcare2026-08-01
    Ambulance Services (for New Mexico Only)UnitedHealthcare2026-08-01

    Related Codes

    HCPCS-LEVEL-II-S2152-SOLID-ORGAN-TRANSPLANTATION-GLOBAL-CARE

    HCPCS Level II S2152: Solid Organ Procurement and Transplantation

    HCPCS-LEVEL-II-S2266-INDUCED-ABORTION-29-TO-31-WEEKS

    HCPCS Level II S2266: Induced Abortion, 29 to 31 Weeks

    HCPCS-LEVEL-II-S3630-EOSINOPHIL-COUNT-BLOOD-DIRECT

    HCPCS Level II S3630: Eosinophil Count, Blood, Direct

    HCPCS-LEVEL-II-S4017-INCOMPLETE-ART-CYCLE-CANCELLED-PRIOR-TO-STIMULATION

    HCPCS Level II S4017: Incomplete Cycle — Cancelled Prior to Stimulation

    HCPCS-LEVEL-II-S8055-ULTRASOUND-GUIDANCE-MULTIFETAL-REDUCTION-TC

    HCPCS Level II S8055: Ultrasound Guidance for Multifetal Pregnancy Reduction

    HCPCS-LEVEL-II-S8940-EQUESTRIAN-HIPPOTHERAPY-PER-SESSION

    HCPCS Level II S8940: Equestrian/Hippotherapy, Per Session

    HCPCS-LEVEL-II-S9024-PARANASAL-SINUS-ULTRASOUND

    HCPCS Level II S9024: Paranasal Sinus Ultrasound

    HCPCS-LEVEL-II-S9366-HOME-TPN-1-2L-PER-DAY-HOME-INFUSION

    HCPCS Level II S9366: Home Infusion TPN, 1–2 L/day

    HCPCS-LEVEL-II-S9446-GROUP-PATIENT-EDUCATION-NON-PHYSICIAN

    HCPCS S9446: Patient Education, Non-Physician Provider, Group, Per Session

    HCPCS-LEVEL-II-S9451-EXERCISE-CLASS-NON-PHYSICIAN-SESSION

    HCPCS S9451: Exercise Classes, Non-Physician Provider, Per Session

    Showing 1–10 of 532

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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