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    OpenPayerBilling CodesHemorrhagic and hematological disorders of newbornICD-10-CM p59-neonatal-jaundice-other-unspecified
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    ICD-10-CM Code For Neonatal Jaundice From Other And Unspecified Causes: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group P59 includes neonatal jaundice diagnoses due to other specified causes and unspecified causes, covering conditions of newborn hyperbilirubinemia not classified under more specific perinatal codes. These ICD-10-CM diagnosis codes are used to document neonatal hyperbilirubinemia presentations, capturing severity, duration, and whether the jaundice stems from hemolytic or nonhemolytic mechanisms relevant to this group. Accurate coding within the ICD-10-CM P59 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM P59: Neonatal Jaundice From Other And Unspecified Causes Overview

    The diagnoses in this group represent forms of jaundice in the newborn period that are not classified elsewhere or are unspecified, involving abnormal bilirubin metabolism or clearance. These conditions affect the hematologic and hepatic function in neonates and can lead to hyperbilirubinemia with clinical jaundice. Accurate coding matters for complete clinical records and correct reimbursement for neonatal care related to bilirubin disorders.

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    When to Use

    Use a code from this group when a newborn presents with jaundice or elevated bilirubin that is not attributable to specific listed perinatal causes and when documentation does not support a more specific code. These codes apply for clinical records, discharge summaries, and claims when the etiology is other specified or unspecified and requires monitoring or treatment during the neonatal period.

    ICD-10-CM Codes

    7 rows

    ICD-10-CM CodeDescription
    P59.0Neonatal jaundice associated with preterm delivery
    P59.1Inspissated bile syndrome
    P59.20Neonatal jaundice from unspecified hepatocellular damage
    P59.29Neonatal jaundice from other hepatocellular damage
    P59.3Neonatal jaundice from breast milk inhibitor
    P59.8Neonatal jaundice from other specified causes
    P59.9Neonatal jaundice, unspecified

    DRG Codes

    4 rows

    DRG CodeDescription
    791Prematurity with Major Problems
    793Full Term Neonate with Major Problems
    794Neonate with Other Significant Problems
    795Normal Newborn

    Typical Clinical Scenarios

    • A term newborn presents to the well-baby nursery on day 3 of life with visible yellowing of the sclera and skin, poor breastfeeding, and a total serum bilirubin modestly elevated above physiologic thresholds for age in hours. The infant is otherwise stable, feeding with slight dehydration, and phototherapy is initiated; the diagnosis is assigned to indicate neonatal jaundice from non-hemolytic, unspecified causes after exclusion of blood group incompatibility and other specific etiologies. Typical codes: P59.9.
    • A preterm infant in the neonatal intensive care unit develops progressively rising conjugated bilirubin and cholestatic picture over the second week of life after TPN exposure and sepsis workup; clinicians document neonatal jaundice due to other specified causes when an identifiable non-physiologic factor (total parenteral nutrition–associated cholestasis) or infectious/inflammatory contributor is implicated. Typical codes: P59.8, P59.29.
    • A neonate readmitted from home on day 5 with marked hyperbilirubinemia, poor feeding, and signs of hemolysis on peripheral smear and elevated direct antiglobulin test is diagnosed with jaundice due to ABO or Rh incompatibility and requires exchange transfusion for acute bilirubin encephalopathy risk. The code is assigned to capture neonatal jaundice attributed to specific hemolytic disease of the newborn as the primary cause of the severe hyperbilirubinemia. Typical codes: P59.0, P59.1.

    Related Codes

    P50-NEWBORN-AFFECTED-BY-INTRAUTERINE-BLOOD-LOSS

    ICD-10-CM Code For Newborn Affected By Intrauterine Blood Loss: Group Overview

    P51-UMBILICAL-HEMORRHAGE-OF-NEWBORN

    ICD-10-CM Code For Umbilical Hemorrhage Of Newborn: Group Overview

    P52-INTRACRANIAL-HEMORRHAGE-NEWBORN

    ICD-10-CM Code For Intracranial Nontraumatic Hemorrhage Of Newborn: Group Overview

    P53-HEMORRHAGIC-DISEASE-OF-NEWBORN

    ICD-10-CM Code For Hemorrhagic Disease Of Newborn: Group Overview

    P54-OTHER-NEONATAL-HEMORRHAGES

    ICD-10-CM Code For Other Neonatal Hemorrhages: Group Overview

    P56-HYDROPS-FETALIS-DUE-TO-HEMOLYTIC-DISEASE

    ICD-10-CM Code For Hydrops Fetalis Due To Hemolytic Disease: Group Overview

    P57-KERNICTERUS-AND-NEONATAL-JAUNDICE

    ICD-10-CM Code For Kernicterus: Group Overview

    P60-DISSEMINATED-INTRAVASCULAR-COAGULATION-NEWBORN

    ICD-10-CM Code For Disseminated Intravascular Coagulation Of Newborn: Group Overview

    P61-OTHER-PERINATAL-HEMATOLOGICAL-DISORDERS

    ICD-10-CM Code For Other Perinatal Hematological Disorders: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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