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    OpenPayerBilling CodesHemorrhagic and hematological disorders of newbornICD-10-CM p56-hydrops-fetalis-due-to-hemolytic-disease
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    ICD-10-CM Code For Hydrops Fetalis Due To Hemolytic Disease: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group P56 includes diagnoses for hydrops fetalis resulting from hemolytic disease of the fetus and newborn, capturing both immune and nonimmune etiologies with associated fetal or neonatal edema and effusions. These ICD-10-CM diagnosis codes are used to document clinical scenarios of severe fetal anemia, high-output cardiac failure, and generalized fetal or neonatal fluid accumulation, capturing disease severity and organ involvement relevant to this group. Accurate coding within the ICD-10-CM P56 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM P56: Hydrops Fetalis Due To Hemolytic Disease Overview

    This group covers hydrops fetalis caused by immune and nonimmune hemolytic disease of the newborn, a severe fetal and neonatal condition characterized by pathologic fluid accumulation in fetal compartments. It targets hematologic and perinatal systems where red blood cell destruction leads to high-output cardiac failure and edema. Accurate coding ensures severity and etiology are documented, which affects clinical care records and supports appropriate reimbursement.

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    When to Use

    Use a code from this group when documentation indicates hydrops fetalis attributable to hemolytic disease of the fetus or newborn, with evidence of fetal or neonatal edema, effusions, or related complications. Choose codes that reflect the specific etiology (immune versus nonimmune) and any documented associated conditions to best represent clinical severity.

    ICD-10-CM Codes

    3 rows

    ICD-10-CM CodeDescription
    P56.0Hydrops fetalis due to isoimmunization
    P56.90Hydrops fetalis due to unspecified hemolytic disease
    P56.99Hydrops fetalis due to other hemolytic disease

    DRG Codes

    2 rows

    DRG CodeDescription
    791Prematurity with Major Problems
    793Full Term Neonate with Major Problems

    Typical Clinical Scenarios

    • A term or near-term neonate is delivered with severe generalized edema, pleural and pericardial effusions, and marked anemia after a pregnancy complicated by maternal alloimmunization (eg, anti-D or other red cell antibodies). The infant presents to the newborn nursery or NICU immediately after birth with respiratory distress and signs of heart failure; laboratory testing shows hemolytic anemia and hyperbilirubinemia consistent with immune-mediated fetal hydrops. A code for hydrops fetalis due to hemolytic disease is assigned because the edema and effusions are the result of fetal/neonatal red blood cell destruction. Typical codes: P56.0.
    • A late-preterm infant born to a mother with unknown or untreated blood type incompatibility develops progressive jaundice and rising direct and indirect bilirubin in the first 24–72 hours, with ultrasound demonstrating ascites and subcutaneous edema without congenital infection. The neonate is admitted to the NICU for phototherapy, exchange transfusion consideration, and monitoring for anemia and cardiopulmonary compromise; the clinical team documents hydrops secondary to hemolytic disease of the fetus/newborn. A code from this group is used to capture hydrops attributed to red cell hemolysis as the underlying cause. Typical codes: P56.0.
    • A newborn with previously treated hemolytic disease now receiving ongoing supportive care in the NICU shows residual generalized edema and pleural effusions while also having complications such as coagulopathy or secondary infection; the chart distinguishes resolved active hemolysis but persistent hydrops-related sequelae. Coding reflects hydrops fetalis related to hemolytic disease when documenting continued manifestations or complications in the postnatal period, using a code that denotes hydrops due to hemolytic disease when the etiology is established. Typical codes: P56.99, P56.90.

    Related Codes

    P50-NEWBORN-AFFECTED-BY-INTRAUTERINE-BLOOD-LOSS

    ICD-10-CM Code For Newborn Affected By Intrauterine Blood Loss: Group Overview

    P51-UMBILICAL-HEMORRHAGE-OF-NEWBORN

    ICD-10-CM Code For Umbilical Hemorrhage Of Newborn: Group Overview

    P52-INTRACRANIAL-HEMORRHAGE-NEWBORN

    ICD-10-CM Code For Intracranial Nontraumatic Hemorrhage Of Newborn: Group Overview

    P53-HEMORRHAGIC-DISEASE-OF-NEWBORN

    ICD-10-CM Code For Hemorrhagic Disease Of Newborn: Group Overview

    P54-OTHER-NEONATAL-HEMORRHAGES

    ICD-10-CM Code For Other Neonatal Hemorrhages: Group Overview

    P57-KERNICTERUS-AND-NEONATAL-JAUNDICE

    ICD-10-CM Code For Kernicterus: Group Overview

    P59-NEONATAL-JAUNDICE-OTHER-UNSPECIFIED

    ICD-10-CM Code For Neonatal Jaundice From Other And Unspecified Causes: Group Overview

    P60-DISSEMINATED-INTRAVASCULAR-COAGULATION-NEWBORN

    ICD-10-CM Code For Disseminated Intravascular Coagulation Of Newborn: Group Overview

    P61-OTHER-PERINATAL-HEMATOLOGICAL-DISORDERS

    ICD-10-CM Code For Other Perinatal Hematological Disorders: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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