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    v1.0.28
    OpenPayerBilling CodesRespiratory and cardiovascular disorders specific to the perinatal periodICD-10-CM p22-respiratory-distress-of-newborn
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    ICD-10-CM Code For Respiratory Distress Of Newborn: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group P22 includes diagnoses for respiratory distress of the newborn such as respiratory distress syndrome of the newborn, transient tachypnea of the newborn, and other specified respiratory difficulties occurring in the perinatal period. These ICD-10-CM diagnosis codes are used to document neonatal respiratory compromise, capture severity of respiratory failure or need for ventilatory support, and note organ system involvement in the early neonatal period. Accurate coding within the ICD-10-CM P22 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM P22: Respiratory Distress Of Newborn Overview

    The diagnoses in this group represent respiratory distress conditions that occur in the newborn period, including transient tachypnea, respiratory distress syndrome, and other perinatal respiratory compromise. These conditions target the neonatal respiratory system and often involve impaired gas exchange, surfactant deficiency, or delayed lung fluid clearance. Accurate coding matters for complete clinical documentation and correct billing because neonatal respiratory disorders influence hospital resource use and payment under newborn care rules.

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    When to Use

    Use a code from this group when a newborn demonstrates clinical signs of respiratory distress such as tachypnea, grunting, nasal flaring, retractions, hypoxemia, or requires supplemental oxygen or ventilatory support. These codes are also used when clinical documentation specifies neonatal respiratory diagnoses or when respiratory status is a focus of newborn care during the perinatal admission.

    ICD-10-CM Codes

    4 rows

    ICD-10-CM CodeDescription
    P22.0Respiratory distress syndrome of newborn
    P22.1Transient tachypnea of newborn
    P22.8Other respiratory distress of newborn
    P22.9Respiratory distress of newborn, unspecified

    DRG Codes

    2 rows

    DRG CodeDescription
    790Extreme Immaturity or Respiratory Distress Syndrome, Neonate
    794Neonate with Other Significant Problems

    Typical Clinical Scenarios

    • A full-term newborn delivered after an uncomplicated pregnancy exhibiting immediate respiratory effort with tachypnea, nasal flaring, grunting, and mild intercostal retractions shortly after birth; oxygen saturation is borderline and the infant requires supplemental oxygen and monitoring in the newborn nursery for transient symptoms that resolve within 48–72 hours. A diagnosis from this group is assigned for transient respiratory difficulty of the neonate without evidence of persistent pulmonary pathology. Typical codes: P22.0, P22.9
    • A preterm infant born at 30 weeks’ gestation in respiratory distress with progressive hypoxemia, diffuse fine inspiratory crackles on exam, and chest radiograph showing ground-glass opacities and low lung volumes; the baby requires continuous positive airway pressure (CPAP) or mechanical ventilation and surfactant therapy in the neonatal intensive care unit. A diagnosis from this group is assigned for respiratory distress related to prematurity and surfactant deficiency. Typical codes: P22.1, P22.9
    • A term newborn with meconium-stained amniotic fluid who is born depressed, requires endotracheal suctioning and mechanical ventilation, and demonstrates persistent pulmonary hypertension and oxygenation failure consistent with meconium aspiration leading to respiratory compromise; the infant may have a prolonged NICU course complicated by secondary infection or bronchopulmonary issues. A diagnosis from this group is assigned for neonatal respiratory distress resulting from aspiration or other specific perinatal pulmonary insult. Typical codes: P22.8, P22.9

    Related Codes

    P19-METABOLIC-ACIDEMIA-IN-NEWBORN

    ICD-10-CM Code For Metabolic Acidemia In Newborn: Group Overview

    P23-CONGENITAL-PNEUMONIA

    ICD-10-CM Code For Congenital Pneumonia: Group Overview

    P24-NEONATAL-ASPIRATION

    ICD-10-CM Code For Neonatal Aspiration: Group Overview

    P25-INTERSTITIAL-EMPHYSEMA-AND-RELATED-CONDITIONS

    ICD-10-CM Code For Interstitial Emphysema And Related Conditions Originating In The Perinatal Period: Group Overview

    P26-PULMONARY-HEMORRHAGE-PERINATAL

    ICD-10-CM Code For Pulmonary Hemorrhage Originating In The Perinatal Period: Group Overview

    P27-CHRONIC-RESPIRATORY-DISEASE-PERINATAL

    ICD-10-CM Code For Chronic Respiratory Disease Originating In The Perinatal Period: Group Overview

    P28-OTHER-RESPIRATORY-PERINATAL-CONDITIONS

    ICD-10-CM Code For Other Respiratory Conditions Originating In The Perinatal Period: Group Overview

    P29-CARDIOVASCULAR-DISORDERS-PERINATAL

    ICD-10-CM Code For Cardiovascular Disorders Originating In The Perinatal Period: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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