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    v1.0.28
    OpenPayerBilling CodesRenal tubulo-interstitial diseasesICD-10-CM n16-renal-tubulo-interstitial-disorders
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    ICD-10-CM Code For Renal Tubulo-Interstitial Disorders In Diseases Classified Elsewhere: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group N16 includes renal tubulo-interstitial disorders that are manifestations of diseases classified elsewhere, such as infections, autoimmune conditions, drug-induced nephropathies, and systemic metabolic disorders affecting the renal interstitium and tubules. These ICD-10-CM diagnosis codes are used to document clinical scenarios where renal tubulo-interstitial pathology is directly related to another primary disease process, capturing organ involvement and the clinical relationship to the underlying condition. Accurate coding within the ICD-10-CM N16 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM N16: Renal Tubulo-Interstitial Disorders In Diseases Classified Elsewhere Overview

    This group includes renal tubulo-interstitial disorders that occur as manifestations of systemic or other specified diseases classified elsewhere, affecting the kidney interstitium and renal tubules. It targets renal parenchymal injury secondary to infectious, inflammatory, metabolic, or toxic processes originating outside the kidney. Accurate coding ensures the clinical relationship between the underlying disease and the renal involvement is documented, which is important for reimbursement and case mix assignment.

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    When to Use

    Use a code from this group when clinical documentation identifies tubulo-interstitial kidney disease as a direct manifestation of another primary disease classified elsewhere. Assign these codes to capture the relationship between the underlying condition and renal involvement for accurate diagnostic, reporting, and billing purposes.

    ICD-10-CM Codes

    1 rows

    ICD-10-CM CodeDescription
    N16Renal tubulo-interstitial disorders in diseases classified elsewhere

    DRG Codes

    3 rows

    DRG CodeDescription
    698Other Kidney and Urinary Tract Diagnoses with MCC
    699Other Kidney and Urinary Tract Diagnoses with CC
    700Other Kidney and Urinary Tract Diagnoses without CC/MCC

    Typical Clinical Scenarios

    • An adult patient with long-standing systemic lupus erythematosus presents with new-onset worsening renal impairment, sterile pyuria, and low-grade proteinuria on outpatient follow-up. Investigation shows interstitial inflammatory infiltrates on renal biopsy consistent with tubulo-interstitial involvement secondary to a systemic disease process, prompting assignment of a code from this group to capture renal tubulo-interstitial disease in the context of another condition. Typical codes: N16
    • An elderly patient is admitted from the emergency department with acute kidney injury after recent exposure to a new antibiotic; urine studies reveal granular casts and eosinophiluria, and imaging excludes obstructive causes. Given the temporal relationship and clinical evidence of tubulo-interstitial damage likely due to a drug-related reaction, a diagnosis from this group is used to document renal tubulo-interstitial disease associated with the offending exposure. Typical codes: N16
    • A middle-aged patient with longstanding diabetes is seen for routine care and found to have persistent low-level hematuria and progressive decline in estimated glomerular filtration rate despite stable albuminuria. Renal biopsy demonstrates chronic tubulo-interstitial fibrosis attributed to a systemic disease process, and a code from this group is assigned to record chronic tubulo-interstitial involvement as a comorbidity influencing management and prognosis. Typical codes: N16

    Related Codes

    N10-ACUTE-PYELONEPHRITIS

    ICD-10-CM Code For Acute Pyelonephritis: Group Overview

    N11-CHRONIC-TUBULO-INTERSTITIAL-NEPHRITIS

    ICD-10-CM Code For Chronic Tubulo-Interstitial Nephritis: Group Overview

    N12-TUBULO-INTERSTITIAL-NEPHRITIS

    ICD-10-CM Code For Tubulo-Interstitial Nephritis Not Specified As Acute Or Chronic: Group Overview

    N13-OBSTRUCTIVE-AND-REFLUX-UROPATHY

    ICD-10-CM Code For Obstructive And Reflux Uropathy: Group Overview

    N14-DRUG-AND-HEAVY-METAL-INDUCED-TUBULO-INTERSTITIAL-CONDITIONS

    ICD-10-CM Code For Drug- And Heavy-Metal-Induced Tubulo-Interstitial And Tubular Conditions: Group Overview

    N15-OTHER-RENAL-TUBULO-INTERSTITIAL-DISEASES

    ICD-10-CM Code For Other Renal Tubulo Interstitial Diseases: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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