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    v1.0.28
    OpenPayerBilling CodesRenal tubulo-interstitial diseasesICD-10-CM n15-other-renal-tubulo-interstitial-diseases
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    ICD-10-CM Code For Other Renal Tubulo Interstitial Diseases: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group N15 includes disorders of the renal tubules and interstitium such as renal tubular acidosis, interstitial nephritis, and other specified tubulo-interstitial kidney diseases that impair tubular function and may lead to chronic kidney injury. These ICD-10-CM diagnosis codes are used to document clinical scenarios involving tubular dysfunction, interstitial inflammation or fibrosis, and associated electrolyte or acid-base disturbances, capturing disease severity and organ involvement. Accurate coding within the ICD-10-CM N15 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM N15: Other Renal Tubulo-Interstitial Diseases Overview

    The diagnoses in the ICD-10-CM N15 group represent non-glomerular kidney disorders that primarily affect the renal tubules and interstitial tissue. These conditions involve tubular dysfunction, interstitial inflammation or fibrosis, and can lead to impaired renal concentrating, electrolyte disturbances, or chronic kidney disease. Accurate coding matters for proper clinical documentation and may affect reimbursement and longitudinal care planning.

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    When to Use

    Use a code from this group when the primary pathology involves renal tubular or interstitial disease rather than glomerular disease, and documentation specifies conditions such as tubulo-interstitial nephritis or renal tubular acidosis. Select the most specific code reflecting etiology, laterality, and chronicity as documented in the medical record.

    ICD-10-CM Codes

    4 rows

    ICD-10-CM CodeDescription
    N15.0Balkan nephropathy
    N15.1Renal and perinephric abscess
    N15.8Other specified renal tubulo-interstitial diseases
    N15.9Renal tubulo-interstitial disease, unspecified

    DRG Codes

    7 rows

    DRG CodeDescription
    689Kidney and Urinary Tract Infections with MCC
    690Kidney and Urinary Tract Infections without MCC
    698Other Kidney and Urinary Tract Diagnoses with MCC
    699Other Kidney and Urinary Tract Diagnoses with CC
    700Other Kidney and Urinary Tract Diagnoses without CC/MCC
    791Prematurity with Major Problems
    793Full Term Neonate with Major Problems

    Typical Clinical Scenarios

    • An adult patient presents to the emergency department with several days of worsening flank pain, fever, and oliguria following a recent episode of severe dehydration and hypotension. Laboratory results show rising serum creatinine and urinalysis with sterile pyuria and mild proteinuria; renal ultrasound excludes obstructive uropathy. The presentation suggests acute tubulo-interstitial injury related to ischemic insult or acute tubular-interstitial nephritis, and a code from this group is assigned to capture the acute tubulo-interstitial process. Typical codes: N15.0, N15.9
    • A middle-aged patient with a history of long-term lithium therapy for bipolar disorder attends nephrology clinic for progressive chronic kidney disease with bland urine sediment and imaging consistent with chronic tubulo-interstitial scarring. The clinician documents a chronic tubulo-interstitial nephropathy likely secondary to chronic medication exposure, requiring staging and longitudinal management. A chronic renal tubulo-interstitial disease code from this group is used to reflect the ongoing interstitial damage as a cause of the patient’s renal dysfunction. Typical codes: N15.1, N15.9
    • A hospitalized patient with systemic autoimmune disease (e.g., Sjögren syndrome) develops worsening kidney function with interstitial inflammatory infiltrates on biopsy and extra-renal autoimmune manifestations. The acute-on-chronic interstitial nephritis is reported as a complication/comorbidity impacting inpatient care and treatment decisions. A specific tubulo-interstitial disease code is assigned to document the renal interstitial involvement of the systemic condition. Typical codes: N15.8, N15.1

    Related Codes

    N10-ACUTE-PYELONEPHRITIS

    ICD-10-CM Code For Acute Pyelonephritis: Group Overview

    N11-CHRONIC-TUBULO-INTERSTITIAL-NEPHRITIS

    ICD-10-CM Code For Chronic Tubulo-Interstitial Nephritis: Group Overview

    N12-TUBULO-INTERSTITIAL-NEPHRITIS

    ICD-10-CM Code For Tubulo-Interstitial Nephritis Not Specified As Acute Or Chronic: Group Overview

    N13-OBSTRUCTIVE-AND-REFLUX-UROPATHY

    ICD-10-CM Code For Obstructive And Reflux Uropathy: Group Overview

    N14-DRUG-AND-HEAVY-METAL-INDUCED-TUBULO-INTERSTITIAL-CONDITIONS

    ICD-10-CM Code For Drug- And Heavy-Metal-Induced Tubulo-Interstitial And Tubular Conditions: Group Overview

    N16-RENAL-TUBULO-INTERSTITIAL-DISORDERS

    ICD-10-CM Code For Renal Tubulo-Interstitial Disorders In Diseases Classified Elsewhere: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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