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    OpenPayerBilling CodesRenal tubulo-interstitial diseasesICD-10-CM n14-drug-and-heavy-metal-induced-tubulo-interstitial-conditions
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    ICD-10-CM Code For Drug- And Heavy-Metal-Induced Tubulo-Interstitial And Tubular Conditions: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group N14 includes diagnoses of tubulo-interstitial and tubular kidney conditions caused by drugs and heavy metals, such as drug-induced interstitial nephritis and heavy-metal nephropathy. These ICD-10-CM diagnosis codes are used to document toxic or medication-related renal tubular injury, capturing organ involvement and the clinical complexity of renal dysfunction. Accurate coding within the ICD-10-CM N14 group supports proper claim adjudication and complete clinical documentation for appropriate reimbursement.

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    ICD-10-CM N14: Drug-And-Heavy-Metal-Induced Tubulo-Interstitial And Tubular Conditions Overview

    This group represents tubulo-interstitial and tubular kidney disorders caused by drugs and heavy metals that impair renal tubular function. It targets renal tubular injury and interstitial inflammation resulting from toxic exposures affecting the kidneys. Accurate coding is important for complete clinical documentation and supports appropriate reimbursement for services related to diagnosis and management.

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    When to Use

    Use a code from this group when clinical documentation indicates renal tubular or interstitial injury linked to a specific drug exposure or heavy-metal poisoning. Codes in this group apply when the etiology is identified as medication- or toxin-related and documented in the medical record.

    ICD-10-CM Codes

    6 rows

    ICD-10-CM CodeDescription
    N14.0Analgesic nephropathy
    N14.11Contrast-induced nephropathy
    N14.19Nephropathy induced by other drugs, medicaments and biological substances
    N14.2Nephropathy induced by unspecified drug, medicament or biological substance
    N14.3Nephropathy induced by heavy metals
    N14.4Toxic nephropathy, not elsewhere classified

    DRG Codes

    3 rows

    DRG CodeDescription
    698Other Kidney and Urinary Tract Diagnoses with MCC
    699Other Kidney and Urinary Tract Diagnoses with CC
    700Other Kidney and Urinary Tract Diagnoses without CC/MCC

    Typical Clinical Scenarios

    • An elderly inpatient develops rising serum creatinine and new-onset tubular proteinuria after several days of intravenous aminoglycoside therapy for sepsis; urine studies show granular casts and electrolyte wasting, and renal ultrasound excludes obstruction. The acute tubular injury is attributed to the nephrotoxic antibiotic, prompting assignment of a drug-induced tubular condition code for an acute toxic effect on renal tubules. Typical codes: N14.0, N14.2
    • A middle-aged patient on long-term cisplatin chemotherapy presents to nephrology with chronic progressive decline in estimated glomerular filtration rate, persistent low-molecular-weight proteinuria, and chronic interstitial fibrosis on biopsy consistent with tubular and interstitial damage from cumulative drug exposure. The chronicity and association with antineoplastic agent exposure lead to coding for a chronic tubular-interstitial condition due to drug toxicity. Typical codes: N14.3, N14.4
    • A dialysis-dependent patient with a history of heavy-metal exposure (occupational mercury exposure years earlier) is admitted for recurrent electrolyte disturbances and documented tubular dysfunction; chart notes indicate residual tubular-interstitial damage from prior toxic exposure contributing as a comorbidity complicating current management. The historical heavy-metal–induced tubulo-interstitial injury is coded to reflect the toxic etiology affecting renal tubular function. Typical codes: N14.11, N14.19

    Related Codes

    N10-ACUTE-PYELONEPHRITIS

    ICD-10-CM Code For Acute Pyelonephritis: Group Overview

    N11-CHRONIC-TUBULO-INTERSTITIAL-NEPHRITIS

    ICD-10-CM Code For Chronic Tubulo-Interstitial Nephritis: Group Overview

    N12-TUBULO-INTERSTITIAL-NEPHRITIS

    ICD-10-CM Code For Tubulo-Interstitial Nephritis Not Specified As Acute Or Chronic: Group Overview

    N13-OBSTRUCTIVE-AND-REFLUX-UROPATHY

    ICD-10-CM Code For Obstructive And Reflux Uropathy: Group Overview

    N15-OTHER-RENAL-TUBULO-INTERSTITIAL-DISEASES

    ICD-10-CM Code For Other Renal Tubulo Interstitial Diseases: Group Overview

    N16-RENAL-TUBULO-INTERSTITIAL-DISORDERS

    ICD-10-CM Code For Renal Tubulo-Interstitial Disorders In Diseases Classified Elsewhere: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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