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    v1.0.28
    OpenPayerBilling CodesGlomerular diseasesICD-10-CM n06-isolated-proteinuria-with-lesion
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    ICD-10-CM Code For Isolated Proteinuria With Specified Morphological Lesion: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group N06 includes diagnoses of isolated proteinuria associated with specified morphological lesions of the glomerulus, such as focal segmental glomerulosclerosis and other histologically defined patterns. These ICD-10-CM diagnosis codes are used to document clinical scenarios where proteinuria is the primary manifestation and where biopsy-proven morphological lesions guide classification, capturing disease severity and histopathologic involvement. Accurate coding within the ICD-10-CM N06 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM N06: Isolated Proteinuria With Specified Morphological Lesion Overview

    This group represents kidney diagnoses characterized by proteinuria with defined glomerular morphological lesions. It targets glomerular diseases of the renal system where protein excretion is a primary clinical finding tied to specific histopathology. Accurate coding affects claim processing and supports appropriate reimbursement by reflecting disease specificity and severity.

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    When to Use

    Use a code from this group when documentation indicates isolated proteinuria accompanied by a specified morphological lesion of the glomerulus, typically supported by biopsy or pathology report. Select the most specific code that reflects the described histologic pattern and clinical presentation to ensure accurate classification.

    ICD-10-CM Codes

    14 rows

    ICD-10-CM CodeDescription
    N06.0Isolated proteinuria with minor glomerular abnormality
    N06.1Isolated proteinuria with focal and segmental glomerular lesions
    N06.20Isolated proteinuria with diffuse membranous glomerulonephritis, unspecified
    N06.21Primary membranous nephropathy with isolated proteinuria
    N06.22Secondary membranous nephropathy with isolated proteinuria
    N06.29Other isolated proteinuria with diffuse membranous glomerulonephritis
    N06.3Isolated proteinuria with diffuse mesangial proliferative glomerulonephritis
    N06.4Isolated proteinuria with diffuse endocapillary proliferative glomerulonephritis
    N06.5Isolated proteinuria with diffuse mesangiocapillary glomerulonephritis
    N06.6Isolated proteinuria with dense deposit disease
    N06.7Isolated proteinuria with diffuse crescentic glomerulonephritis
    N06.8Isolated proteinuria with other morphologic lesion
    N06.9Isolated proteinuria with unspecified morphologic lesion
    N06.AIsolated proteinuria with C3 glomerulonephritis

    DRG Codes

    3 rows

    DRG CodeDescription
    698Other Kidney and Urinary Tract Diagnoses with MCC
    699Other Kidney and Urinary Tract Diagnoses with CC
    700Other Kidney and Urinary Tract Diagnoses without CC/MCC

    Typical Clinical Scenarios

    • An adult patient with known membranous nephropathy is seen in clinic for routine follow-up after recent urine studies show persistent nephrotic-range proteinuria but stable renal function; the visit documents proteinuria attributable to the patient’s identified glomerular morphological lesion without other systemic disease activity, so an isolated proteinuria with specified morphological lesion code is assigned. Typical codes: N06.0, N06.1
    • An adolescent presents to the emergency department with sudden-onset edema and frothy urine; renal biopsy performed during the admission reveals focal segmental glomerulosclerosis as the cause of heavy proteinuria, and the coder assigns an isolated proteinuria code specifying the morphological lesion identified on biopsy to capture the acute presentation of protein loss. Typical codes: N06.20, N06.21
    • A middle-aged patient with long-standing diabetes is followed by nephrology for progressive proteinuria after a biopsy shows diabetic glomerulosclerosis with dominant proteinuria but without overt nephritic syndrome; an isolated proteinuria with specified morphological lesion code is used to record the biopsy-proven glomerular lesion as the principal diagnosis for the proteinuric state. Typical codes: N06.3, N06.4

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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